Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World
We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tool...
Gespeichert in:
| Veröffentlicht in: | Journal of chemical information and modeling 2007-11, Vol.47 (6), p.1999-2014 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2014 |
|---|---|
| container_issue | 6 |
| container_start_page | 1999 |
| container_title | Journal of chemical information and modeling |
| container_volume | 47 |
| creator | Agrafiotis, Dimitris K Alex, Simson Dai, Heng Derkinderen, An Farnum, Michael Gates, Peter Izrailev, Sergei Jaeger, Edward P Konstant, Paul Leung, Albert Lobanov, Victor S Marichal, Patrick Martin, Douglas Rassokhin, Dmitrii N Shemanarev, Maxim Skalkin, Andrew Stong, John Tabruyn, Tom Vermeiren, Marleen Wan, Jackson Xu, Xiang Yang Yao, Xiang |
| description | We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system consists of three major components: (1) a data warehouse, which combines data from multiple chemical and pharmacological transactional databases, designed for supreme query performance; (2) a state-of-the-art application suite, which facilitates data upload, retrieval, mining, and reporting, and (3) a workspace, which facilitates collaboration and data sharing by allowing users to share queries, templates, results, and reports across project teams, campuses, and other organizational units. Chemical intelligence, performance, and analytical sophistication lie at the heart of the new system, which was developed entirely in-house. ABCD is used routinely by more than 1000 scientists around the world and is rapidly expanding into other functional areas within the J&J organization. |
| doi_str_mv | 10.1021/ci700267w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68541581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68541581</sourcerecordid><originalsourceid>FETCH-LOGICAL-a378t-a48afde243279990727df9a05ccc9986f0b0fa849bbc5d46e05bbee8b541eb573</originalsourceid><addsrcrecordid>eNpl0U9PFDEUAPCJ0QiiB7-AmZhA4DDS6fTP1Nsyi4oS_0QUb02nfbMUuy22u-Dqxatf009iZRcwemjal_763ktfUTys0ZMa4XpXW44QZvziVrFeUyIqwdCn21dnKthacS-lU4SaRjB8t1irueAN4Xi9-D4y58prMOWeDS5MrFauVN6U3QlML4OxTTqcQ1yU26O9brzz9NePn2UHfhaVs9-sn_wlXvlw4cBMoLQ-ZykP_AnETN2iHIO-epOLHYfozP3izqBcggerfaP48Gz_qHtRHb55ftCNDivV8HZWKdKqwQAmDeZCCMQxN4NQiGqthWjZgHo0qJaIvtfUEAaI9j1A21NSQ095s1FsLfOexfBlDmkmp7ljcE55CPMkWZslbesMH_8DT8M8-tybxDXDhOSV0c4S6RhSijDIs2inKi5kjeSfccjrcWT7aJVw3k_B3MjV_2dQLYFNM_h6fa_iZ8l4w6k8evtespcfCT1mr-W77DeXXul009z_hX8D802hyw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216244624</pqid></control><display><type>article</type><title>Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Agrafiotis, Dimitris K ; Alex, Simson ; Dai, Heng ; Derkinderen, An ; Farnum, Michael ; Gates, Peter ; Izrailev, Sergei ; Jaeger, Edward P ; Konstant, Paul ; Leung, Albert ; Lobanov, Victor S ; Marichal, Patrick ; Martin, Douglas ; Rassokhin, Dmitrii N ; Shemanarev, Maxim ; Skalkin, Andrew ; Stong, John ; Tabruyn, Tom ; Vermeiren, Marleen ; Wan, Jackson ; Xu, Xiang Yang ; Yao, Xiang</creator><creatorcontrib>Agrafiotis, Dimitris K ; Alex, Simson ; Dai, Heng ; Derkinderen, An ; Farnum, Michael ; Gates, Peter ; Izrailev, Sergei ; Jaeger, Edward P ; Konstant, Paul ; Leung, Albert ; Lobanov, Victor S ; Marichal, Patrick ; Martin, Douglas ; Rassokhin, Dmitrii N ; Shemanarev, Maxim ; Skalkin, Andrew ; Stong, John ; Tabruyn, Tom ; Vermeiren, Marleen ; Wan, Jackson ; Xu, Xiang Yang ; Yao, Xiang</creatorcontrib><description>We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system consists of three major components: (1) a data warehouse, which combines data from multiple chemical and pharmacological transactional databases, designed for supreme query performance; (2) a state-of-the-art application suite, which facilitates data upload, retrieval, mining, and reporting, and (3) a workspace, which facilitates collaboration and data sharing by allowing users to share queries, templates, results, and reports across project teams, campuses, and other organizational units. Chemical intelligence, performance, and analytical sophistication lie at the heart of the new system, which was developed entirely in-house. ABCD is used routinely by more than 1000 scientists around the world and is rapidly expanding into other functional areas within the J&J organization.</description><identifier>ISSN: 1549-9596</identifier><identifier>EISSN: 1549-960X</identifier><identifier>DOI: 10.1021/ci700267w</identifier><identifier>PMID: 17973472</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Biology ; Chemistry ; Computational Biology ; Computers ; Drugs ; Imaging, Three-Dimensional ; Pharmaceuticals ; Pharmacology ; R&D ; Research & development</subject><ispartof>Journal of chemical information and modeling, 2007-11, Vol.47 (6), p.1999-2014</ispartof><rights>Copyright © 2007 American Chemical Society</rights><rights>Copyright American Chemical Society Nov 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a378t-a48afde243279990727df9a05ccc9986f0b0fa849bbc5d46e05bbee8b541eb573</citedby><cites>FETCH-LOGICAL-a378t-a48afde243279990727df9a05ccc9986f0b0fa849bbc5d46e05bbee8b541eb573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ci700267w$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ci700267w$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17973472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agrafiotis, Dimitris K</creatorcontrib><creatorcontrib>Alex, Simson</creatorcontrib><creatorcontrib>Dai, Heng</creatorcontrib><creatorcontrib>Derkinderen, An</creatorcontrib><creatorcontrib>Farnum, Michael</creatorcontrib><creatorcontrib>Gates, Peter</creatorcontrib><creatorcontrib>Izrailev, Sergei</creatorcontrib><creatorcontrib>Jaeger, Edward P</creatorcontrib><creatorcontrib>Konstant, Paul</creatorcontrib><creatorcontrib>Leung, Albert</creatorcontrib><creatorcontrib>Lobanov, Victor S</creatorcontrib><creatorcontrib>Marichal, Patrick</creatorcontrib><creatorcontrib>Martin, Douglas</creatorcontrib><creatorcontrib>Rassokhin, Dmitrii N</creatorcontrib><creatorcontrib>Shemanarev, Maxim</creatorcontrib><creatorcontrib>Skalkin, Andrew</creatorcontrib><creatorcontrib>Stong, John</creatorcontrib><creatorcontrib>Tabruyn, Tom</creatorcontrib><creatorcontrib>Vermeiren, Marleen</creatorcontrib><creatorcontrib>Wan, Jackson</creatorcontrib><creatorcontrib>Xu, Xiang Yang</creatorcontrib><creatorcontrib>Yao, Xiang</creatorcontrib><title>Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World</title><title>Journal of chemical information and modeling</title><addtitle>J. Chem. Inf. Model</addtitle><description>We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system consists of three major components: (1) a data warehouse, which combines data from multiple chemical and pharmacological transactional databases, designed for supreme query performance; (2) a state-of-the-art application suite, which facilitates data upload, retrieval, mining, and reporting, and (3) a workspace, which facilitates collaboration and data sharing by allowing users to share queries, templates, results, and reports across project teams, campuses, and other organizational units. Chemical intelligence, performance, and analytical sophistication lie at the heart of the new system, which was developed entirely in-house. ABCD is used routinely by more than 1000 scientists around the world and is rapidly expanding into other functional areas within the J&J organization.</description><subject>Biology</subject><subject>Chemistry</subject><subject>Computational Biology</subject><subject>Computers</subject><subject>Drugs</subject><subject>Imaging, Three-Dimensional</subject><subject>Pharmaceuticals</subject><subject>Pharmacology</subject><subject>R&D</subject><subject>Research & development</subject><issn>1549-9596</issn><issn>1549-960X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0U9PFDEUAPCJ0QiiB7-AmZhA4DDS6fTP1Nsyi4oS_0QUb02nfbMUuy22u-Dqxatf009iZRcwemjal_763ktfUTys0ZMa4XpXW44QZvziVrFeUyIqwdCn21dnKthacS-lU4SaRjB8t1irueAN4Xi9-D4y58prMOWeDS5MrFauVN6U3QlML4OxTTqcQ1yU26O9brzz9NePn2UHfhaVs9-sn_wlXvlw4cBMoLQ-ZykP_AnETN2iHIO-epOLHYfozP3izqBcggerfaP48Gz_qHtRHb55ftCNDivV8HZWKdKqwQAmDeZCCMQxN4NQiGqthWjZgHo0qJaIvtfUEAaI9j1A21NSQ095s1FsLfOexfBlDmkmp7ljcE55CPMkWZslbesMH_8DT8M8-tybxDXDhOSV0c4S6RhSijDIs2inKi5kjeSfccjrcWT7aJVw3k_B3MjV_2dQLYFNM_h6fa_iZ8l4w6k8evtespcfCT1mr-W77DeXXul009z_hX8D802hyw</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Agrafiotis, Dimitris K</creator><creator>Alex, Simson</creator><creator>Dai, Heng</creator><creator>Derkinderen, An</creator><creator>Farnum, Michael</creator><creator>Gates, Peter</creator><creator>Izrailev, Sergei</creator><creator>Jaeger, Edward P</creator><creator>Konstant, Paul</creator><creator>Leung, Albert</creator><creator>Lobanov, Victor S</creator><creator>Marichal, Patrick</creator><creator>Martin, Douglas</creator><creator>Rassokhin, Dmitrii N</creator><creator>Shemanarev, Maxim</creator><creator>Skalkin, Andrew</creator><creator>Stong, John</creator><creator>Tabruyn, Tom</creator><creator>Vermeiren, Marleen</creator><creator>Wan, Jackson</creator><creator>Xu, Xiang Yang</creator><creator>Yao, Xiang</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SC</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World</title><author>Agrafiotis, Dimitris K ; Alex, Simson ; Dai, Heng ; Derkinderen, An ; Farnum, Michael ; Gates, Peter ; Izrailev, Sergei ; Jaeger, Edward P ; Konstant, Paul ; Leung, Albert ; Lobanov, Victor S ; Marichal, Patrick ; Martin, Douglas ; Rassokhin, Dmitrii N ; Shemanarev, Maxim ; Skalkin, Andrew ; Stong, John ; Tabruyn, Tom ; Vermeiren, Marleen ; Wan, Jackson ; Xu, Xiang Yang ; Yao, Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a378t-a48afde243279990727df9a05ccc9986f0b0fa849bbc5d46e05bbee8b541eb573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biology</topic><topic>Chemistry</topic><topic>Computational Biology</topic><topic>Computers</topic><topic>Drugs</topic><topic>Imaging, Three-Dimensional</topic><topic>Pharmaceuticals</topic><topic>Pharmacology</topic><topic>R&D</topic><topic>Research & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agrafiotis, Dimitris K</creatorcontrib><creatorcontrib>Alex, Simson</creatorcontrib><creatorcontrib>Dai, Heng</creatorcontrib><creatorcontrib>Derkinderen, An</creatorcontrib><creatorcontrib>Farnum, Michael</creatorcontrib><creatorcontrib>Gates, Peter</creatorcontrib><creatorcontrib>Izrailev, Sergei</creatorcontrib><creatorcontrib>Jaeger, Edward P</creatorcontrib><creatorcontrib>Konstant, Paul</creatorcontrib><creatorcontrib>Leung, Albert</creatorcontrib><creatorcontrib>Lobanov, Victor S</creatorcontrib><creatorcontrib>Marichal, Patrick</creatorcontrib><creatorcontrib>Martin, Douglas</creatorcontrib><creatorcontrib>Rassokhin, Dmitrii N</creatorcontrib><creatorcontrib>Shemanarev, Maxim</creatorcontrib><creatorcontrib>Skalkin, Andrew</creatorcontrib><creatorcontrib>Stong, John</creatorcontrib><creatorcontrib>Tabruyn, Tom</creatorcontrib><creatorcontrib>Vermeiren, Marleen</creatorcontrib><creatorcontrib>Wan, Jackson</creatorcontrib><creatorcontrib>Xu, Xiang Yang</creatorcontrib><creatorcontrib>Yao, Xiang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Computer and Information Systems Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chemical information and modeling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agrafiotis, Dimitris K</au><au>Alex, Simson</au><au>Dai, Heng</au><au>Derkinderen, An</au><au>Farnum, Michael</au><au>Gates, Peter</au><au>Izrailev, Sergei</au><au>Jaeger, Edward P</au><au>Konstant, Paul</au><au>Leung, Albert</au><au>Lobanov, Victor S</au><au>Marichal, Patrick</au><au>Martin, Douglas</au><au>Rassokhin, Dmitrii N</au><au>Shemanarev, Maxim</au><au>Skalkin, Andrew</au><au>Stong, John</au><au>Tabruyn, Tom</au><au>Vermeiren, Marleen</au><au>Wan, Jackson</au><au>Xu, Xiang Yang</au><au>Yao, Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World</atitle><jtitle>Journal of chemical information and modeling</jtitle><addtitle>J. Chem. Inf. Model</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>47</volume><issue>6</issue><spage>1999</spage><epage>2014</epage><pages>1999-2014</pages><issn>1549-9596</issn><eissn>1549-960X</eissn><abstract>We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system consists of three major components: (1) a data warehouse, which combines data from multiple chemical and pharmacological transactional databases, designed for supreme query performance; (2) a state-of-the-art application suite, which facilitates data upload, retrieval, mining, and reporting, and (3) a workspace, which facilitates collaboration and data sharing by allowing users to share queries, templates, results, and reports across project teams, campuses, and other organizational units. Chemical intelligence, performance, and analytical sophistication lie at the heart of the new system, which was developed entirely in-house. ABCD is used routinely by more than 1000 scientists around the world and is rapidly expanding into other functional areas within the J&J organization.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>17973472</pmid><doi>10.1021/ci700267w</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1549-9596 |
| ispartof | Journal of chemical information and modeling, 2007-11, Vol.47 (6), p.1999-2014 |
| issn | 1549-9596 1549-960X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68541581 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Biology Chemistry Computational Biology Computers Drugs Imaging, Three-Dimensional Pharmaceuticals Pharmacology R&D Research & development |
| title | Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A30%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Advanced%20Biological%20and%20Chemical%20Discovery%20(ABCD):%E2%80%89%20Centralizing%20Discovery%20Knowledge%20in%20an%20Inherently%20Decentralized%20World&rft.jtitle=Journal%20of%20chemical%20information%20and%20modeling&rft.au=Agrafiotis,%20Dimitris%20K&rft.date=2007-11-01&rft.volume=47&rft.issue=6&rft.spage=1999&rft.epage=2014&rft.pages=1999-2014&rft.issn=1549-9596&rft.eissn=1549-960X&rft_id=info:doi/10.1021/ci700267w&rft_dat=%3Cproquest_cross%3E68541581%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=216244624&rft_id=info:pmid/17973472&rfr_iscdi=true |