Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy
ABSTRACT Objective: Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to assess liver fibrosis by measuring liver stiffness in adult patients. The usefulness of FibroScan in children with chronic liver diseases is unknown. The aim of this prospective study was to evalu...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2007-10, Vol.45 (4), p.443-450 |
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| creator | Lédinghen, Victor Le Bail, Brigitte Rebouissoux, Laurent Fournier, Céline Foucher, Juliette Miette, Véronique Castéra, Laurent Sandrin, Laurent Merrouche, Wassil Lavrand, Frédéric Lamireau, Thierry |
| description | ABSTRACT
Objective:
Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to assess liver fibrosis by measuring liver stiffness in adult patients. The usefulness of FibroScan in children with chronic liver diseases is unknown. The aim of this prospective study was to evaluate the feasibility of liver stiffness measurement and to compare FibroScan, Fibrotest, and aspartate transaminase to platelets ratio index (APRI) with liver biopsy for the diagnosis of cirrhosis in children with chronic liver diseases.
Patients and Methods:
Between February 2004 and October 2005, 116 consecutive children with chronic liver diseases were prospectively included. All except 1 child (58 boys, mean age 10.7 years) could have noninvasive tests for fibrosis: FibroScan, Fibrotest, and APRI, and, when necessary, a liver biopsy (n = 33).
Results:
FibroScan, Fibrotest, and APRI were correlated with clinical or biological parameters of chronic liver diseases, but the FibroScan marker correlated most with all parameters. By histology, the METAVIR fibrosis category score was F1 in 7 cases, F2 in 8 cases, F3 in 6 cases, and F4 in 12 cases. FibroScan, Fibrotest, and APRI were significantly correlated with the METAVIR fibrosis score. For the diagnosis of cirrhosis, the area under the receiver operating characteristic curve was 0.88, 0.73, and 0.73 for FibroScan, Fibrotest, and APRI, respectively.
Conclusions:
These results indicate that liver stiffness measurement is feasible in children and is related to liver fibrosis. A specific probe dedicated to children and slender patients has thus been developed and is currently under evaluation. The FibroScan equipped with this specific probe could become a useful tool for the management of chronic liver diseases in children. |
| doi_str_mv | 10.1097/MPG.0b013e31812e56ff |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68540226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68540226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4800-20ebba3e4f5206a0a2ea00ae794d351b0cc0741fad4560f63326030bb23bf6473</originalsourceid><addsrcrecordid>eNqNUcFuEzEUXCEQLYU_QMgXOHXLs73rTZA4tBEpRSlEtBXH1dvdZ2LweoPtpeSb-EkcEikSJw6WZb-Z8Xgmy55zOOMwrV5fLy_PoAEuSfIJF1QqrR9kx7yUKi8mwB9mxyCqKhecq6PsSQjfAKAqSnicHfEJSEiD4-z3wvwkz26i0dpRCOyaMIyeenKRGcdmK2M7T47dBeO-srlp_HDTonvD5gloGmNN3CT62G0Yuo7Nhn6N3oTBsS8mrnaESCGesvOQJhEjsVuPLmBvHAZicWBLm24txcA-YzQDu3Id_Tr9q7ezd2GGddg8zR5ptIGe7feT7G7-7nb2Pl98uryanS_yNv0bcgHUNCip0KUAhYCCEACpmhadLHkDbZty4Bq7olSglZRCpTiaRshGq6KSJ9mrne7aDz_G5L3uTWjJWnQ0jKFWk7IAIVQCFjtg64cQPOl67U2PflNzqLcl1amk-t-SEu3FXn9seuoOpH0rCfByD8DQotUprtaEA27KC1ECHN6_H2wkH77b8Z58vSK0cVWnuqHklUqBQMW3pzwtvqW93dOMpc1_ea4_LD_KizkUSgr5B3t8v8Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68540226</pqid></control><display><type>article</type><title>Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Lédinghen, Victor ; Le Bail, Brigitte ; Rebouissoux, Laurent ; Fournier, Céline ; Foucher, Juliette ; Miette, Véronique ; Castéra, Laurent ; Sandrin, Laurent ; Merrouche, Wassil ; Lavrand, Frédéric ; Lamireau, Thierry</creator><creatorcontrib>Lédinghen, Victor ; Le Bail, Brigitte ; Rebouissoux, Laurent ; Fournier, Céline ; Foucher, Juliette ; Miette, Véronique ; Castéra, Laurent ; Sandrin, Laurent ; Merrouche, Wassil ; Lavrand, Frédéric ; Lamireau, Thierry</creatorcontrib><description>ABSTRACT
Objective:
Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to assess liver fibrosis by measuring liver stiffness in adult patients. The usefulness of FibroScan in children with chronic liver diseases is unknown. The aim of this prospective study was to evaluate the feasibility of liver stiffness measurement and to compare FibroScan, Fibrotest, and aspartate transaminase to platelets ratio index (APRI) with liver biopsy for the diagnosis of cirrhosis in children with chronic liver diseases.
Patients and Methods:
Between February 2004 and October 2005, 116 consecutive children with chronic liver diseases were prospectively included. All except 1 child (58 boys, mean age 10.7 years) could have noninvasive tests for fibrosis: FibroScan, Fibrotest, and APRI, and, when necessary, a liver biopsy (n = 33).
Results:
FibroScan, Fibrotest, and APRI were correlated with clinical or biological parameters of chronic liver diseases, but the FibroScan marker correlated most with all parameters. By histology, the METAVIR fibrosis category score was F1 in 7 cases, F2 in 8 cases, F3 in 6 cases, and F4 in 12 cases. FibroScan, Fibrotest, and APRI were significantly correlated with the METAVIR fibrosis score. For the diagnosis of cirrhosis, the area under the receiver operating characteristic curve was 0.88, 0.73, and 0.73 for FibroScan, Fibrotest, and APRI, respectively.
Conclusions:
These results indicate that liver stiffness measurement is feasible in children and is related to liver fibrosis. A specific probe dedicated to children and slender patients has thus been developed and is currently under evaluation. The FibroScan equipped with this specific probe could become a useful tool for the management of chronic liver diseases in children.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e31812e56ff</identifier><identifier>PMID: 18030211</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Aspartate Aminotransferases - blood ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - metabolism ; Biopsy ; Blood Platelets - enzymology ; Child ; Cirrhosis ; Cystic fibrosis ; Digestive system ; Elasticity Imaging Techniques - instrumentation ; Elasticity Imaging Techniques - methods ; Elasticity Imaging Techniques - statistics & numerical data ; Errors of metabolism ; Feasibility Studies ; Female ; Fibrosis ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Liver - diagnostic imaging ; Liver - pathology ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnosis ; Liver Diseases - complications ; Liver stiffness ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Metabolic diseases ; Miscellaneous hereditary metabolic disorders ; Other diseases. Semiology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Platelet Count ; Portal hypertension ; Prospective Studies ; ROC Curve ; Sensitivity and Specificity ; Severity of Illness Index</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2007-10, Vol.45 (4), p.443-450</ispartof><rights>2007 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2007 Lippincott Williams & Wilkins, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4800-20ebba3e4f5206a0a2ea00ae794d351b0cc0741fad4560f63326030bb23bf6473</citedby><cites>FETCH-LOGICAL-c4800-20ebba3e4f5206a0a2ea00ae794d351b0cc0741fad4560f63326030bb23bf6473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e31812e56ff$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e31812e56ff$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19142500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18030211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lédinghen, Victor</creatorcontrib><creatorcontrib>Le Bail, Brigitte</creatorcontrib><creatorcontrib>Rebouissoux, Laurent</creatorcontrib><creatorcontrib>Fournier, Céline</creatorcontrib><creatorcontrib>Foucher, Juliette</creatorcontrib><creatorcontrib>Miette, Véronique</creatorcontrib><creatorcontrib>Castéra, Laurent</creatorcontrib><creatorcontrib>Sandrin, Laurent</creatorcontrib><creatorcontrib>Merrouche, Wassil</creatorcontrib><creatorcontrib>Lavrand, Frédéric</creatorcontrib><creatorcontrib>Lamireau, Thierry</creatorcontrib><title>Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objective:
Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to assess liver fibrosis by measuring liver stiffness in adult patients. The usefulness of FibroScan in children with chronic liver diseases is unknown. The aim of this prospective study was to evaluate the feasibility of liver stiffness measurement and to compare FibroScan, Fibrotest, and aspartate transaminase to platelets ratio index (APRI) with liver biopsy for the diagnosis of cirrhosis in children with chronic liver diseases.
Patients and Methods:
Between February 2004 and October 2005, 116 consecutive children with chronic liver diseases were prospectively included. All except 1 child (58 boys, mean age 10.7 years) could have noninvasive tests for fibrosis: FibroScan, Fibrotest, and APRI, and, when necessary, a liver biopsy (n = 33).
Results:
FibroScan, Fibrotest, and APRI were correlated with clinical or biological parameters of chronic liver diseases, but the FibroScan marker correlated most with all parameters. By histology, the METAVIR fibrosis category score was F1 in 7 cases, F2 in 8 cases, F3 in 6 cases, and F4 in 12 cases. FibroScan, Fibrotest, and APRI were significantly correlated with the METAVIR fibrosis score. For the diagnosis of cirrhosis, the area under the receiver operating characteristic curve was 0.88, 0.73, and 0.73 for FibroScan, Fibrotest, and APRI, respectively.
Conclusions:
These results indicate that liver stiffness measurement is feasible in children and is related to liver fibrosis. A specific probe dedicated to children and slender patients has thus been developed and is currently under evaluation. The FibroScan equipped with this specific probe could become a useful tool for the management of chronic liver diseases in children.</description><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Biopsy</subject><subject>Blood Platelets - enzymology</subject><subject>Child</subject><subject>Cirrhosis</subject><subject>Cystic fibrosis</subject><subject>Digestive system</subject><subject>Elasticity Imaging Techniques - instrumentation</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Elasticity Imaging Techniques - statistics & numerical data</subject><subject>Errors of metabolism</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Diseases - complications</subject><subject>Liver stiffness</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Miscellaneous hereditary metabolic disorders</subject><subject>Other diseases. Semiology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Platelet Count</subject><subject>Portal hypertension</subject><subject>Prospective Studies</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcFuEzEUXCEQLYU_QMgXOHXLs73rTZA4tBEpRSlEtBXH1dvdZ2LweoPtpeSb-EkcEikSJw6WZb-Z8Xgmy55zOOMwrV5fLy_PoAEuSfIJF1QqrR9kx7yUKi8mwB9mxyCqKhecq6PsSQjfAKAqSnicHfEJSEiD4-z3wvwkz26i0dpRCOyaMIyeenKRGcdmK2M7T47dBeO-srlp_HDTonvD5gloGmNN3CT62G0Yuo7Nhn6N3oTBsS8mrnaESCGesvOQJhEjsVuPLmBvHAZicWBLm24txcA-YzQDu3Id_Tr9q7ezd2GGddg8zR5ptIGe7feT7G7-7nb2Pl98uryanS_yNv0bcgHUNCip0KUAhYCCEACpmhadLHkDbZty4Bq7olSglZRCpTiaRshGq6KSJ9mrne7aDz_G5L3uTWjJWnQ0jKFWk7IAIVQCFjtg64cQPOl67U2PflNzqLcl1amk-t-SEu3FXn9seuoOpH0rCfByD8DQotUprtaEA27KC1ECHN6_H2wkH77b8Z58vSK0cVWnuqHklUqBQMW3pzwtvqW93dOMpc1_ea4_LD_KizkUSgr5B3t8v8Y</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Lédinghen, Victor</creator><creator>Le Bail, Brigitte</creator><creator>Rebouissoux, Laurent</creator><creator>Fournier, Céline</creator><creator>Foucher, Juliette</creator><creator>Miette, Véronique</creator><creator>Castéra, Laurent</creator><creator>Sandrin, Laurent</creator><creator>Merrouche, Wassil</creator><creator>Lavrand, Frédéric</creator><creator>Lamireau, Thierry</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy</title><author>Lédinghen, Victor ; Le Bail, Brigitte ; Rebouissoux, Laurent ; Fournier, Céline ; Foucher, Juliette ; Miette, Véronique ; Castéra, Laurent ; Sandrin, Laurent ; Merrouche, Wassil ; Lavrand, Frédéric ; Lamireau, Thierry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4800-20ebba3e4f5206a0a2ea00ae794d351b0cc0741fad4560f63326030bb23bf6473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Biopsy</topic><topic>Blood Platelets - enzymology</topic><topic>Child</topic><topic>Cirrhosis</topic><topic>Cystic fibrosis</topic><topic>Digestive system</topic><topic>Elasticity Imaging Techniques - instrumentation</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Elasticity Imaging Techniques - statistics & numerical data</topic><topic>Errors of metabolism</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Diseases - complications</topic><topic>Liver stiffness</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Miscellaneous hereditary metabolic disorders</topic><topic>Other diseases. Semiology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Platelet Count</topic><topic>Portal hypertension</topic><topic>Prospective Studies</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lédinghen, Victor</creatorcontrib><creatorcontrib>Le Bail, Brigitte</creatorcontrib><creatorcontrib>Rebouissoux, Laurent</creatorcontrib><creatorcontrib>Fournier, Céline</creatorcontrib><creatorcontrib>Foucher, Juliette</creatorcontrib><creatorcontrib>Miette, Véronique</creatorcontrib><creatorcontrib>Castéra, Laurent</creatorcontrib><creatorcontrib>Sandrin, Laurent</creatorcontrib><creatorcontrib>Merrouche, Wassil</creatorcontrib><creatorcontrib>Lavrand, Frédéric</creatorcontrib><creatorcontrib>Lamireau, Thierry</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lédinghen, Victor</au><au>Le Bail, Brigitte</au><au>Rebouissoux, Laurent</au><au>Fournier, Céline</au><au>Foucher, Juliette</au><au>Miette, Véronique</au><au>Castéra, Laurent</au><au>Sandrin, Laurent</au><au>Merrouche, Wassil</au><au>Lavrand, Frédéric</au><au>Lamireau, Thierry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2007-10</date><risdate>2007</risdate><volume>45</volume><issue>4</issue><spage>443</spage><epage>450</epage><pages>443-450</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objective:
Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to assess liver fibrosis by measuring liver stiffness in adult patients. The usefulness of FibroScan in children with chronic liver diseases is unknown. The aim of this prospective study was to evaluate the feasibility of liver stiffness measurement and to compare FibroScan, Fibrotest, and aspartate transaminase to platelets ratio index (APRI) with liver biopsy for the diagnosis of cirrhosis in children with chronic liver diseases.
Patients and Methods:
Between February 2004 and October 2005, 116 consecutive children with chronic liver diseases were prospectively included. All except 1 child (58 boys, mean age 10.7 years) could have noninvasive tests for fibrosis: FibroScan, Fibrotest, and APRI, and, when necessary, a liver biopsy (n = 33).
Results:
FibroScan, Fibrotest, and APRI were correlated with clinical or biological parameters of chronic liver diseases, but the FibroScan marker correlated most with all parameters. By histology, the METAVIR fibrosis category score was F1 in 7 cases, F2 in 8 cases, F3 in 6 cases, and F4 in 12 cases. FibroScan, Fibrotest, and APRI were significantly correlated with the METAVIR fibrosis score. For the diagnosis of cirrhosis, the area under the receiver operating characteristic curve was 0.88, 0.73, and 0.73 for FibroScan, Fibrotest, and APRI, respectively.
Conclusions:
These results indicate that liver stiffness measurement is feasible in children and is related to liver fibrosis. A specific probe dedicated to children and slender patients has thus been developed and is currently under evaluation. The FibroScan equipped with this specific probe could become a useful tool for the management of chronic liver diseases in children.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18030211</pmid><doi>10.1097/MPG.0b013e31812e56ff</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 2007-10, Vol.45 (4), p.443-450 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Aspartate Aminotransferases - blood Biological and medical sciences Biomarkers - blood Biomarkers - metabolism Biopsy Blood Platelets - enzymology Child Cirrhosis Cystic fibrosis Digestive system Elasticity Imaging Techniques - instrumentation Elasticity Imaging Techniques - methods Elasticity Imaging Techniques - statistics & numerical data Errors of metabolism Feasibility Studies Female Fibrosis Gastroenterology. Liver. Pancreas. Abdomen Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Liver - diagnostic imaging Liver - pathology Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Liver Diseases - complications Liver stiffness Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Metabolic diseases Miscellaneous hereditary metabolic disorders Other diseases. Semiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet Count Portal hypertension Prospective Studies ROC Curve Sensitivity and Specificity Severity of Illness Index |
| title | Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy |
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