Metabolic Disconnection Between the Mediodorsal Nucleus of the Thalamus and Cortical Brodmann's Areas of the Left Hemisphere in Schizophrenia
OBJECTIVE: The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia. METHOD: They used [18F]fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal compari...
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| Veröffentlicht in: | The American journal of psychiatry 2005-09, Vol.162 (9), p.1733-1735 |
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| container_title | The American journal of psychiatry |
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| creator | Mitelman, Serge A. Byne, William Kemether, Eileen M. Hazlett, Erin A. Buchsbaum, Monte S. |
| description | OBJECTIVE: The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia. METHOD: They used [18F]fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal comparison subjects. RESULTS: A metabolic disconnection was observed in patients with schizophrenia in the left hemisphere between the mediodorsal nucleus and widespread frontotemporal cortical regions, and stronger-than-normal intercorrelations were found between the pulvinar and superior temporal, selected parietal, posterior cingulate, and occipital areas. CONCLUSIONS: Deficits in the functional interrelationships between the left frontotemporal cortices and the left mediodorsal nucleus of the thalamus complement inferences from postmortem and magnetic resonance imaging volumetric studies identifying a thalamic diathesis in schizophrenia. |
| doi_str_mv | 10.1176/appi.ajp.162.9.1733 |
| format | Article |
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METHOD: They used [18F]fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal comparison subjects. RESULTS: A metabolic disconnection was observed in patients with schizophrenia in the left hemisphere between the mediodorsal nucleus and widespread frontotemporal cortical regions, and stronger-than-normal intercorrelations were found between the pulvinar and superior temporal, selected parietal, posterior cingulate, and occipital areas. CONCLUSIONS: Deficits in the functional interrelationships between the left frontotemporal cortices and the left mediodorsal nucleus of the thalamus complement inferences from postmortem and magnetic resonance imaging volumetric studies identifying a thalamic diathesis in schizophrenia.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.162.9.1733</identifier><identifier>PMID: 16135634</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Aged ; Biological and medical sciences ; Brain ; Brain Mapping - methods ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - metabolism ; Female ; Fluorodeoxyglucose F18 ; Frontal Lobe - metabolism ; Functional Laterality - physiology ; Glucose - metabolism ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Mediodorsal Thalamic Nucleus - diagnostic imaging ; Mediodorsal Thalamic Nucleus - metabolism ; Middle Aged ; Neural Pathways - metabolism ; NMR ; Nuclear magnetic resonance ; Pathogens ; Positron-Emission Tomography ; Psychology. 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METHOD: They used [18F]fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal comparison subjects. RESULTS: A metabolic disconnection was observed in patients with schizophrenia in the left hemisphere between the mediodorsal nucleus and widespread frontotemporal cortical regions, and stronger-than-normal intercorrelations were found between the pulvinar and superior temporal, selected parietal, posterior cingulate, and occipital areas. CONCLUSIONS: Deficits in the functional interrelationships between the left frontotemporal cortices and the left mediodorsal nucleus of the thalamus complement inferences from postmortem and magnetic resonance imaging volumetric studies identifying a thalamic diathesis in schizophrenia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Mapping - methods</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - metabolism</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Frontal Lobe - metabolism</subject><subject>Functional Laterality - physiology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mediodorsal Thalamic Nucleus - diagnostic imaging</subject><subject>Mediodorsal Thalamic Nucleus - metabolism</subject><subject>Middle Aged</subject><subject>Neural Pathways - metabolism</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pathogens</subject><subject>Positron-Emission Tomography</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - metabolism</subject><subject>Temporal Lobe - metabolism</subject><subject>Verbal Learning - physiology</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUQCMEokPhC5CQhQSsEvxIbGfZDo8iTWFBkdhZHuda8SixUzsRav-Bf8bTGbUSC1hZVz73eYriJcEVIYK_19PkKr2bKsJp1VZEMPaoWJGGNaWgVD4uVhhjWrYN-3lSPEtpl0PMBH1anBBOWMNZvSp-X8Kst2FwBn1wyQTvwcwueHQO8y8Aj-Ye0CV0LnQhJj2gr4sZYEko2Luvq14Pesyx9h1ahzg7k6HzGLpRe_8uobMI-p7egJ3RBYwuTT1EQM6j76Z3t2HqI3innxdPrB4SvDi-p8WPTx-v1hfl5tvnL-uzTalrRueyo7UAIYwhhnFpaq1113amsW3HiZSi1hgbuRU0b9lR2JIaW0Ok4NbKhlHLTou3h7pTDNcLpFnlkQwMg_YQlqR4xlrO2X9B0tasbRuawdd_gbuwRJ-XUJTiWtaS7yF2gEwMKUWwaopu1PFGEaz2TtXeqcpOVXaqWrV3mrNeHUsv2xG6h5yjxAy8OQI65evbqL1x6YETuJVS4szhA3fX5X6-f_X-A2w-vQY</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Mitelman, Serge A.</creator><creator>Byne, William</creator><creator>Kemether, Eileen M.</creator><creator>Hazlett, Erin A.</creator><creator>Buchsbaum, Monte S.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Metabolic Disconnection Between the Mediodorsal Nucleus of the Thalamus and Cortical Brodmann's Areas of the Left Hemisphere in Schizophrenia</title><author>Mitelman, Serge A. ; Byne, William ; Kemether, Eileen M. ; Hazlett, Erin A. ; Buchsbaum, Monte S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a432t-d247e77cc1c368c4aaad9dc5f9d618874a00c8b72135d2eb140fc1876ff8532f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Mapping - methods</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - metabolism</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Frontal Lobe - metabolism</topic><topic>Functional Laterality - physiology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mediodorsal Thalamic Nucleus - diagnostic imaging</topic><topic>Mediodorsal Thalamic Nucleus - metabolism</topic><topic>Middle Aged</topic><topic>Neural Pathways - metabolism</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pathogens</topic><topic>Positron-Emission Tomography</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - metabolism</topic><topic>Temporal Lobe - metabolism</topic><topic>Verbal Learning - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitelman, Serge A.</creatorcontrib><creatorcontrib>Byne, William</creatorcontrib><creatorcontrib>Kemether, Eileen M.</creatorcontrib><creatorcontrib>Hazlett, Erin A.</creatorcontrib><creatorcontrib>Buchsbaum, Monte S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitelman, Serge A.</au><au>Byne, William</au><au>Kemether, Eileen M.</au><au>Hazlett, Erin A.</au><au>Buchsbaum, Monte S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Disconnection Between the Mediodorsal Nucleus of the Thalamus and Cortical Brodmann's Areas of the Left Hemisphere in Schizophrenia</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>162</volume><issue>9</issue><spage>1733</spage><epage>1735</epage><pages>1733-1735</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia. METHOD: They used [18F]fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal comparison subjects. RESULTS: A metabolic disconnection was observed in patients with schizophrenia in the left hemisphere between the mediodorsal nucleus and widespread frontotemporal cortical regions, and stronger-than-normal intercorrelations were found between the pulvinar and superior temporal, selected parietal, posterior cingulate, and occipital areas. CONCLUSIONS: Deficits in the functional interrelationships between the left frontotemporal cortices and the left mediodorsal nucleus of the thalamus complement inferences from postmortem and magnetic resonance imaging volumetric studies identifying a thalamic diathesis in schizophrenia.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>16135634</pmid><doi>10.1176/appi.ajp.162.9.1733</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Adult and adolescent clinical studies Aged Biological and medical sciences Brain Brain Mapping - methods Cerebral Cortex - diagnostic imaging Cerebral Cortex - metabolism Female Fluorodeoxyglucose F18 Frontal Lobe - metabolism Functional Laterality - physiology Glucose - metabolism Humans Magnetic Resonance Imaging Male Medical sciences Mediodorsal Thalamic Nucleus - diagnostic imaging Mediodorsal Thalamic Nucleus - metabolism Middle Aged Neural Pathways - metabolism NMR Nuclear magnetic resonance Pathogens Positron-Emission Tomography Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Temporal Lobe - metabolism Verbal Learning - physiology |
| title | Metabolic Disconnection Between the Mediodorsal Nucleus of the Thalamus and Cortical Brodmann's Areas of the Left Hemisphere in Schizophrenia |
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