Determinants of Plasma Homocysteine Levels and Carotid Intima-Media Thickness in Japanese
Although hyperhomocysteinemia is considered to be a key risk factor for atherosclerosis, especially in Western countries, its role in the Asian population is still controversial. In this study, we evaluated the determinants of homocysteine and carotid intima-media thickness, a clinical marker for th...
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| Veröffentlicht in: | Asia Pacific Journal of Clinical Nutrition 2007-12, Vol.16 (4), p.698-703 |
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| container_title | Asia Pacific Journal of Clinical Nutrition |
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| creator | Takamura, Noboru Abe, Yasuyo Nakazato, Mio Maeda, Takahiro Wada, Mitsuhiro Nakashima, Kenichiro Kusano, Yosuke Aoyagi, Kiyoshi |
| description | Although hyperhomocysteinemia is considered to be a key risk factor for atherosclerosis, especially in Western countries, its role in the Asian population is still controversial. In this study, we evaluated the determinants of homocysteine and carotid intima-media thickness, a clinical marker for the detection of atherosclerosis, in Japanese. In 289 Japanese adults (age 37-86 yrs), we screened plasma total homocysteine by high performance liquid chromatography and evaluated maximum carotid intima-media thickness by ultrasound. Other blood chemistry values were also measured. Total homocysteine levels were higher in men than in women and increased with age. In multiple regression analysis, adjusted for age and sex, serum creatinine was a powerful determinant of homocysteine (β=3.3, p＜0.01). Maximum carotid intima-media thickness was higher in men than in women and increased with age. When adjusted for age and sex, systolic blood pressure was independently correlated with maximum carotid intima-media thickness (β=0.001, p＜0.01). Our current results support previous findings that in addition to age and sex, serum creatinine and systolic blood pressure are independent determinants of homocysteine and carotid intima-media thickness, respectively. |
| doi_str_mv | 10.6133/apjcn.2007.16.4.16 |
| format | Article |
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In this study, we evaluated the determinants of homocysteine and carotid intima-media thickness, a clinical marker for the detection of atherosclerosis, in Japanese. In 289 Japanese adults (age 37-86 yrs), we screened plasma total homocysteine by high performance liquid chromatography and evaluated maximum carotid intima-media thickness by ultrasound. Other blood chemistry values were also measured. Total homocysteine levels were higher in men than in women and increased with age. In multiple regression analysis, adjusted for age and sex, serum creatinine was a powerful determinant of homocysteine (β=3.3, p＜0.01). Maximum carotid intima-media thickness was higher in men than in women and increased with age. When adjusted for age and sex, systolic blood pressure was independently correlated with maximum carotid intima-media thickness (β=0.001, p＜0.01). Our current results support previous findings that in addition to age and sex, serum creatinine and systolic blood pressure are independent determinants of homocysteine and carotid intima-media thickness, respectively.</description><identifier>ISSN: 0964-7058</identifier><identifier>EISSN: 1440-6047</identifier><identifier>DOI: 10.6133/apjcn.2007.16.4.16</identifier><identifier>PMID: 18042531</identifier><language>eng</language><publisher>Australia: HEC Press</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Aging - pathology ; Arteriosclerosis - blood ; Arteriosclerosis - epidemiology ; Atherosclerosis ; Blood pressure ; Blood Pressure - physiology ; Body mass index ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Carotid arteries ; Carotid Arteries - diagnostic imaging ; Cholesterol ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Creatinine ; Creatinine - blood ; Female ; Homocysteine ; Homocysteine - blood ; Humans ; Japan ; Longitudinal studies ; Male ; Medical screening ; Metabolism ; Middle Aged ; Plasma ; Regression analysis ; Risk Factors ; Sex Factors ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonic imaging ; Ultrasonography ; Veins & arteries ; Vitamin B ; Womens health</subject><ispartof>Asia Pacific Journal of Clinical Nutrition, 2007-12, Vol.16 (4), p.698-703</ispartof><rights>Copyright Copyright Agency Limited (Distributor) Dec 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18042531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takamura, Noboru</creatorcontrib><creatorcontrib>Abe, Yasuyo</creatorcontrib><creatorcontrib>Nakazato, Mio</creatorcontrib><creatorcontrib>Maeda, Takahiro</creatorcontrib><creatorcontrib>Wada, Mitsuhiro</creatorcontrib><creatorcontrib>Nakashima, Kenichiro</creatorcontrib><creatorcontrib>Kusano, Yosuke</creatorcontrib><creatorcontrib>Aoyagi, Kiyoshi</creatorcontrib><title>Determinants of Plasma Homocysteine Levels and Carotid Intima-Media Thickness in Japanese</title><title>Asia Pacific Journal of Clinical Nutrition</title><addtitle>Asia Pac J Clin Nutr</addtitle><description>Although hyperhomocysteinemia is considered to be a key risk factor for atherosclerosis, especially in Western countries, its role in the Asian population is still controversial. In this study, we evaluated the determinants of homocysteine and carotid intima-media thickness, a clinical marker for the detection of atherosclerosis, in Japanese. In 289 Japanese adults (age 37-86 yrs), we screened plasma total homocysteine by high performance liquid chromatography and evaluated maximum carotid intima-media thickness by ultrasound. Other blood chemistry values were also measured. Total homocysteine levels were higher in men than in women and increased with age. In multiple regression analysis, adjusted for age and sex, serum creatinine was a powerful determinant of homocysteine (β=3.3, p＜0.01). Maximum carotid intima-media thickness was higher in men than in women and increased with age. When adjusted for age and sex, systolic blood pressure was independently correlated with maximum carotid intima-media thickness (β=0.001, p＜0.01). Our current results support previous findings that in addition to age and sex, serum creatinine and systolic blood pressure are independent determinants of homocysteine and carotid intima-media thickness, respectively.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - epidemiology</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Carotid arteries</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Cholesterol</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Japan</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Medical screening</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Veins & arteries</subject><subject>Vitamin B</subject><subject>Womens health</subject><issn>0964-7058</issn><issn>1440-6047</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkclOwzAQhi0EgrK8AAdkceCWMvZ4iY-oLAUVwQEOnCIncYVL4pQ4ReLtcUURgsss0jejf_4h5JjBWDHEc7tcVGHMAfSYqbFIYYuMmBCQKRB6m4zAKJFpkPke2Y9xAQAoQO6SPZaD4BLZiLxcusH1rQ82DJF2c_rY2NhaOu3arvqMg_PB0Zn7cE2kNtR0Yvtu8DW9DYNvbXbvam_p06uv3oKLkfpA7-zSptodkp25baI72uQD8nx99TSZZrOHm9vJxSyzCGzItBEKlLASeFlr1Nq4UorK6pIzwZ1WiJKjVcYgRykh5wocTwO8nqtSlnhAzr73LvvufeXiULQ-Vq5pkopuFQuVSzRcmwSe_gMX3aoPSVvBGeZoQECCTjbQqmxdXSz7dGb_Wfw4loDpN2B97wf_u2Nt9trrYv0QxlNiCIrp5Dr72yiTFxoQvwB6-H-r</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Takamura, Noboru</creator><creator>Abe, Yasuyo</creator><creator>Nakazato, Mio</creator><creator>Maeda, Takahiro</creator><creator>Wada, Mitsuhiro</creator><creator>Nakashima, Kenichiro</creator><creator>Kusano, Yosuke</creator><creator>Aoyagi, Kiyoshi</creator><general>HEC Press</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>Determinants of Plasma Homocysteine Levels and Carotid Intima-Media Thickness in Japanese</title><author>Takamura, Noboru ; 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In this study, we evaluated the determinants of homocysteine and carotid intima-media thickness, a clinical marker for the detection of atherosclerosis, in Japanese. In 289 Japanese adults (age 37-86 yrs), we screened plasma total homocysteine by high performance liquid chromatography and evaluated maximum carotid intima-media thickness by ultrasound. Other blood chemistry values were also measured. Total homocysteine levels were higher in men than in women and increased with age. In multiple regression analysis, adjusted for age and sex, serum creatinine was a powerful determinant of homocysteine (β=3.3, p＜0.01). Maximum carotid intima-media thickness was higher in men than in women and increased with age. When adjusted for age and sex, systolic blood pressure was independently correlated with maximum carotid intima-media thickness (β=0.001, p＜0.01). Our current results support previous findings that in addition to age and sex, serum creatinine and systolic blood pressure are independent determinants of homocysteine and carotid intima-media thickness, respectively.</abstract><cop>Australia</cop><pub>HEC Press</pub><pmid>18042531</pmid><doi>10.6133/apjcn.2007.16.4.16</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Age Factors Aged Aged, 80 and over Aging - pathology Arteriosclerosis - blood Arteriosclerosis - epidemiology Atherosclerosis Blood pressure Blood Pressure - physiology Body mass index Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Carotid arteries Carotid Arteries - diagnostic imaging Cholesterol Chromatography Chromatography, High Pressure Liquid - methods Creatinine Creatinine - blood Female Homocysteine Homocysteine - blood Humans Japan Longitudinal studies Male Medical screening Metabolism Middle Aged Plasma Regression analysis Risk Factors Sex Factors Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonic imaging Ultrasonography Veins & arteries Vitamin B Womens health |
| title | Determinants of Plasma Homocysteine Levels and Carotid Intima-Media Thickness in Japanese |
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