The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system

Effective antiretroviral therapy (ART) has reduced the incidence of HIV-associated neurocognitive impairment (HNCI) but its prevalence remains high. Clinical trials have yet to identify a consistently effective treatment for HNCI, other than ART, but in vitro data support that some drugs approved by...

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Veröffentlicht in:	Journal of neuroimmune pharmacology 2007-03, Vol.2 (1), p.120-127
Hauptverfasser:	Letendre, Scott L, Marquie-Beck, Jennifer, Ellis, Ronald J, Woods, Steven Paul, Best, Brookie, Clifford, David B, Collier, Ann C, Gelman, Benjamin B, Marra, Christina, McArthur, Justin C, McCutchan, J Allen, Morgello, Susan, Simpson, David, Alexander, Terry J, Durelle, Janis, Heaton, Robert, Grant, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - cerebrospinal fluid Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - psychology Acquired Immunodeficiency Syndrome - virology Adult Anti-Retroviral Agents - chemical synthesis Anti-Retroviral Agents - pharmacology Antidepressants Antiretroviral drugs Antiviral drugs Central Nervous System - drug effects Central Nervous System - metabolism Central Nervous System - virology Cohort analysis Cohort Studies Drug Design Drug development FDA approval Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemical synthesis Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Middle Aged Prospective Studies Serotonin Uptake Inhibitors - chemical synthesis Serotonin Uptake Inhibitors - pharmacology Statins
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