Modification of Tubulin Cysteines by Nitric Oxide and Nitroxyl Donors Alters Tubulin Polymerization Activity

The modification of reduced cysteines of proteins by nitric oxide alters protein function, structure, and potentially, interactions with downstream signaling targets. We assessed the effect of the S-nitroso compounds S-nitrosoglutathione and S-nitroso-N-acetyl-penicillamine, the NO donor 2-(N,N-diet...

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Veröffentlicht in:	Chemical research in toxicology 2007-11, Vol.20 (11), p.1693-1700
Hauptverfasser:	Landino, Lisa M, Koumas, Maria T, Mason, Courtney E, Alston, Jane A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cysteine - chemistry Glutathione - metabolism Nitric Oxide - pharmacology Nitric Oxide Donors - pharmacology Polymers - chemistry S-Nitrosoglutathione - pharmacology Tubulin - chemistry
Online-Zugang:	Volltext
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