Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice

In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR v...

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Veröffentlicht in:Vision research (Oxford) 2007-12, Vol.47 (26), p.3229-3237
Hauptverfasser: Aldrovani, M., Guaraldo, A.M.A., Vidal, B.C.
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Guaraldo, A.M.A.
Vidal, B.C.
description In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher for NOD corneas. After staining with Toluidine Blue, NOD and BALB/c corneas showed negative LD. The results of this study demonstrate that diabetes was capable of altering the corneal optical anisotropies, possibly altering the number of intermolecular crosslinks in collagen fibers.
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subjects Animals
Anisotropy
Biological and medical sciences
Birefringence
Collagen
Cornea
Corneal Stroma
Diabetes
Diabetes Mellitus - physiopathology
Diabetes. Impaired glucose tolerance
Dichroism
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Eye and associated structures. Visual pathways and centers. Vision
Female
Fibrillar Collagens - physiology
Fundamental and applied biological sciences. Psychology
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Staining and Labeling
Vertebrates: nervous system and sense organs
title Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice
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