Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice
In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR v...
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| Veröffentlicht in: | Vision research (Oxford) 2007-12, Vol.47 (26), p.3229-3237 |
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| creator | Aldrovani, M. Guaraldo, A.M.A. Vidal, B.C. |
| description | In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher for NOD corneas. After staining with Toluidine Blue, NOD and BALB/c corneas showed negative LD. The results of this study demonstrate that diabetes was capable of altering the corneal optical anisotropies, possibly altering the number of intermolecular crosslinks in collagen fibers. |
| doi_str_mv | 10.1016/j.visres.2007.02.011 |
| format | Article |
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Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher for NOD corneas. After staining with Toluidine Blue, NOD and BALB/c corneas showed negative LD. The results of this study demonstrate that diabetes was capable of altering the corneal optical anisotropies, possibly altering the number of intermolecular crosslinks in collagen fibers.</description><identifier>ISSN: 0042-6989</identifier><identifier>EISSN: 1878-5646</identifier><identifier>DOI: 10.1016/j.visres.2007.02.011</identifier><identifier>PMID: 18028980</identifier><identifier>CODEN: VISRAM</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Anisotropy ; Biological and medical sciences ; Birefringence ; Collagen ; Cornea ; Corneal Stroma ; Diabetes ; Diabetes Mellitus - physiopathology ; Diabetes. Impaired glucose tolerance ; Dichroism ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fibrillar Collagens - physiology ; Fundamental and applied biological sciences. Psychology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Staining and Labeling ; Vertebrates: nervous system and sense organs</subject><ispartof>Vision research (Oxford), 2007-12, Vol.47 (26), p.3229-3237</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-b8a41cd922c7e15d7ae1acb210086bcffa4743c3efdc19bcc46de911bac3c85f3</citedby><cites>FETCH-LOGICAL-c390t-b8a41cd922c7e15d7ae1acb210086bcffa4743c3efdc19bcc46de911bac3c85f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.visres.2007.02.011$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19915094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18028980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aldrovani, M.</creatorcontrib><creatorcontrib>Guaraldo, A.M.A.</creatorcontrib><creatorcontrib>Vidal, B.C.</creatorcontrib><title>Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice</title><title>Vision research (Oxford)</title><addtitle>Vision Res</addtitle><description>In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher for NOD corneas. After staining with Toluidine Blue, NOD and BALB/c corneas showed negative LD. The results of this study demonstrate that diabetes was capable of altering the corneal optical anisotropies, possibly altering the number of intermolecular crosslinks in collagen fibers.</description><subject>Animals</subject><subject>Anisotropy</subject><subject>Biological and medical sciences</subject><subject>Birefringence</subject><subject>Collagen</subject><subject>Cornea</subject><subject>Corneal Stroma</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dichroism</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fibrillar Collagens - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred NOD</subject><subject>Staining and Labeling</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0042-6989</issn><issn>1878-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVpiB03_6CUvbS33Yy0X9IlUEKbBAK-NGehnR0VGe9HNOtA_32U2OBbT2KG5x29PEJ8lVBIkM3NrngNHIkLBdAWoAqQ8pNYS93qvG6q5rNYA1Qqb4w2K3HFvIME1spcipXUoLTRsBbP23kJ6PaZGwNPS5zmQJyFMcMpjpT2nHaDS-N-7_7SmPnQUeTMp23WB9dRimc8T-PiRpoOnA0B6Yu48G7PdH16N-L5968_dw_50_b-8e7nU46lgSXvtKsk9kYpbEnWfetIOuyUBNBNh967qq1KLMn3KE2HWDU9GSk7hyXq2pcb8eN4d47Ty4F4sUNgpFT1o4ttdF3W2lQJrI4gxomTNW_nGAYX_1kJ9l2n3dmjTvuu04KySWeKfTvdP3QD9efQyV8Cvp8Ax8mij27EwGfOGFnDx_-3R46SjddA0TIGGpH6EAkX20_h_03eAJkwl-g</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Aldrovani, M.</creator><creator>Guaraldo, A.M.A.</creator><creator>Vidal, B.C.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice</title><author>Aldrovani, M. ; Guaraldo, A.M.A. ; Vidal, B.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-b8a41cd922c7e15d7ae1acb210086bcffa4743c3efdc19bcc46de911bac3c85f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anisotropy</topic><topic>Biological and medical sciences</topic><topic>Birefringence</topic><topic>Collagen</topic><topic>Cornea</topic><topic>Corneal Stroma</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Dichroism</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fibrillar Collagens - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred NOD</topic><topic>Staining and Labeling</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aldrovani, M.</creatorcontrib><creatorcontrib>Guaraldo, A.M.A.</creatorcontrib><creatorcontrib>Vidal, B.C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vision research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aldrovani, M.</au><au>Guaraldo, A.M.A.</au><au>Vidal, B.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice</atitle><jtitle>Vision research (Oxford)</jtitle><addtitle>Vision Res</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>47</volume><issue>26</issue><spage>3229</spage><epage>3237</epage><pages>3229-3237</pages><issn>0042-6989</issn><eissn>1878-5646</eissn><coden>VISRAM</coden><abstract>In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher for NOD corneas. After staining with Toluidine Blue, NOD and BALB/c corneas showed negative LD. The results of this study demonstrate that diabetes was capable of altering the corneal optical anisotropies, possibly altering the number of intermolecular crosslinks in collagen fibers.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18028980</pmid><doi>10.1016/j.visres.2007.02.011</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Anisotropy Biological and medical sciences Birefringence Collagen Cornea Corneal Stroma Diabetes Diabetes Mellitus - physiopathology Diabetes. Impaired glucose tolerance Dichroism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Eye and associated structures. Visual pathways and centers. Vision Female Fibrillar Collagens - physiology Fundamental and applied biological sciences. Psychology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred NOD Staining and Labeling Vertebrates: nervous system and sense organs |
| title | Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice |
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