Modelling the production of nisin by Lactococcus lactis in fed-batch culture
Nisin production in batch culture and fed-batch cultures (sucrose feeding rates were 6, 7, 8, and 10 g l(-1) h(-1), respectively) by Lactococcus lactis subsp. lactis ATCC 11454 was investigated. Nisin production showed primary metabolite kinetics, and could be improved apparently by altering the fee...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2005-08, Vol.68 (3), p.322-326 |
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| creator | Lv, Wenhua Zhang, Xiaoyan Cong, Wei |
| description | Nisin production in batch culture and fed-batch cultures (sucrose feeding rates were 6, 7, 8, and 10 g l(-1) h(-1), respectively) by Lactococcus lactis subsp. lactis ATCC 11454 was investigated. Nisin production showed primary metabolite kinetics, and could be improved apparently by altering the feeding strategy. The nisin titer reached its maximum, 4,185 IU ml(-1), by constant addition of sucrose at a feeding rate of 7 g l(-1) h(-1); an increase in 58% over that of the batch culture (2,658 IU ml(-1)). Nisin biosynthesis was affected strongly by the residual sucrose concentration during the feeding. Finally, a mathematical model was developed to simulate the cell growth, sucrose consumption, lactic acid production and nisin production. The model was able to describe the fermentation process in all cases. |
| doi_str_mv | 10.1007/s00253-005-1892-7 |
| format | Article |
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Nisin production showed primary metabolite kinetics, and could be improved apparently by altering the feeding strategy. The nisin titer reached its maximum, 4,185 IU ml(-1), by constant addition of sucrose at a feeding rate of 7 g l(-1) h(-1); an increase in 58% over that of the batch culture (2,658 IU ml(-1)). Nisin biosynthesis was affected strongly by the residual sucrose concentration during the feeding. Finally, a mathematical model was developed to simulate the cell growth, sucrose consumption, lactic acid production and nisin production. 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Nisin production showed primary metabolite kinetics, and could be improved apparently by altering the feeding strategy. The nisin titer reached its maximum, 4,185 IU ml(-1), by constant addition of sucrose at a feeding rate of 7 g l(-1) h(-1); an increase in 58% over that of the batch culture (2,658 IU ml(-1)). Nisin biosynthesis was affected strongly by the residual sucrose concentration during the feeding. Finally, a mathematical model was developed to simulate the cell growth, sucrose consumption, lactic acid production and nisin production. The model was able to describe the fermentation process in all cases.</description><subject>Acid production</subject><subject>Analysis</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Culture Media - metabolism</subject><subject>Feedback</subject><subject>Feeding rates</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lactic Acid - metabolism</subject><subject>Lactococcus</subject><subject>Lactococcus lactis</subject><subject>Lactococcus lactis - growth & development</subject><subject>Lactococcus lactis - metabolism</subject><subject>Metabolites</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbial engineering. Fermentation and microbial culture technology</subject><subject>Microbiology</subject><subject>Models, Theoretical</subject><subject>Nisin - biosynthesis</subject><subject>Peptides</subject><subject>Sucrose</subject><subject>Sucrose - metabolism</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU2LFDEQhoMo7uzqD_AiQXDBQ7SSdL6Oy-LHwojgxzkk6WQ2S0-ydrrB_fdmmIEFL54qUE-Kt-pB6BWF9xRAfWgATHACIAjVhhH1BG3owBkBSYenaANUCaKE0WfovLU7AMq0lM_RGRXSMA3DBm2_1jFOUy47vNxGfD_XcQ1LrgXXhEtuuWD_gLcuLDXUENaGp_7ODfdGiiPxbgm3OKzTss7xBXqW3NTiy1O9QL8-ffx5_YVsv32-ub7akjAIvRCngFEdNA1emSSCdpFFpRlz48jTMEimHHhnIvfaG065SpyOIx2S9EmC5xfo8ji3x_29xrbYfW6hr-FKrGuzUgsuhOT_BakxwiimOvjmH_CurnPpS1jJRJ_Wr9qhd0do56Zocwm1LPHPsnNra_bmx3d7xQG07reHztIjG-ba2hyTvZ_z3s0PloI9yLNHebbLswd59hDi9SnE6vdxfPxxstWBtyfAteCmNLsScnvkFAhujOR_AXN9n9k</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Lv, Wenhua</creator><creator>Zhang, Xiaoyan</creator><creator>Cong, Wei</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Modelling the production of nisin by Lactococcus lactis in fed-batch culture</title><author>Lv, Wenhua ; Zhang, Xiaoyan ; Cong, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-a70218c81cb79f5c8ae2e7822add3f44627a0ba9e3b8b93137f31dd14f6bf60b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acid production</topic><topic>Analysis</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Culture Media - metabolism</topic><topic>Feedback</topic><topic>Feeding rates</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. 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Nisin production showed primary metabolite kinetics, and could be improved apparently by altering the feeding strategy. The nisin titer reached its maximum, 4,185 IU ml(-1), by constant addition of sucrose at a feeding rate of 7 g l(-1) h(-1); an increase in 58% over that of the batch culture (2,658 IU ml(-1)). Nisin biosynthesis was affected strongly by the residual sucrose concentration during the feeding. Finally, a mathematical model was developed to simulate the cell growth, sucrose consumption, lactic acid production and nisin production. The model was able to describe the fermentation process in all cases.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15692804</pmid><doi>10.1007/s00253-005-1892-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Acid production Analysis Bacteria Biological and medical sciences Biosynthesis Biotechnology Culture Media - metabolism Feedback Feeding rates Fermentation Fundamental and applied biological sciences. Psychology Lactic Acid - metabolism Lactococcus Lactococcus lactis Lactococcus lactis - growth & development Lactococcus lactis - metabolism Metabolites Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Microbiology Models, Theoretical Nisin - biosynthesis Peptides Sucrose Sucrose - metabolism |
| title | Modelling the production of nisin by Lactococcus lactis in fed-batch culture |
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