Long-term Protection in Hamsters against Human Parainfluenza Virus Type 3 Following Mucosal or Combinations of Mucosal and Systemic Immunizations with Chimeric Alphavirus-based Replicon Particles

No licensed vaccines are available to protect against parainfluenza virus type 3 (PIV3), a significant health risk for infants. In search of a safe vaccine, we used an alphavirus-based chimeric vector, consisting of Sindbis virus (SIN) structural proteins and Venezuelan equine encephalitis virus (VE...

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Veröffentlicht in:	Scandinavian journal of immunology 2007-12, Vol.66 (6), p.645-653
Hauptverfasser:	Greer, C.E, Zhou, F, Goodsell, A, Legg, H.S, Tang, Z, zur Megede, J, Uematsu, Y, Polo, J.M, Vajdy, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Alphavirus - genetics Alphavirus - immunology Animals Antibodies, Viral - blood Antibodies, Viral - immunology Cricetinae Disease Models, Animal Encephalitis Virus, Venezuelan Equine - immunology Humans Immunization Injections, Intramuscular Mucous Membrane - immunology Parainfluenza Vaccines - immunology Parainfluenza virus Parainfluenza Virus 3, Human - growth & development Parainfluenza Virus 3, Human - immunology Replicon - genetics Replicon - immunology RNA, Viral - genetics RNA, Viral - immunology Sindbis virus Sindbis Virus - immunology Vaccines, Attenuated - immunology Vaccines, Attenuated - therapeutic use Vaccines, Synthetic - immunology Venezuelan equine encephalitis virus
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