Serum Matrix Metalloproteinase-8 Concentrations Are Associated With Cardiovascular Outcome in Men
OBJECTIVE—In culture studies matrix metalloproteinase (MMP)-8 thins the protecting fibrous cap of the atherosclerotic plaque thereby increasing its vulnerability. Results on the association of serum MMP-8 concentrations and cardiovascular diseases (CVD) are, however, scarce and contradictory. METHOD...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-12, Vol.27 (12), p.2722-2728 |
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| container_title | Arteriosclerosis, thrombosis, and vascular biology |
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| creator | Tuomainen, Anita M Nyyssönen, Kristiina Laukkanen, Jari A Tervahartiala, Taina Tuomainen, Tomi-Pekka Salonen, Jukka T Sorsa, Timo Pussinen, Pirkko J |
| description | OBJECTIVE—In culture studies matrix metalloproteinase (MMP)-8 thins the protecting fibrous cap of the atherosclerotic plaque thereby increasing its vulnerability. Results on the association of serum MMP-8 concentrations and cardiovascular diseases (CVD) are, however, scarce and contradictory.
METHODS AND RESULTS—We analyzed the association between CVD or subclinical atherosclerosis and serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations of 1018 men with the follow-up time of 10 years. MMP-8 concentrations or MMP-8/TIMP-1 ratios were higher in men with prevalent CVD or subclinical atherosclerosis at baseline than those without. In men free of CVD at baseline, MMP-8 concentrations associated with acute myocardial infarction, death from coronary heart disease (CHD), CVD, or from any cause with relative risks (RR) (95% CI) of 1.138 (1.009 to 1.284), 1.188 (1.034 to 1.365), 1.171 (1.026 to 1.338), and 1.136 (1.018 to 1.269), respectively, and MMP-8/TIMP-1 ratio with CHD death with an RR of 1.206 (1.028 to 1.414) per standard deviation (SD) increase. In men with no prevalent CVD but with subclinical atherosclerosis at baseline, elevated serum MMP-8 concentration predicted CVD death with an RR of 3.03 (1.09 to 8.44). TIMP-1 concentrations alone had no predictive value.
CONCLUSIONS—The results indicate that serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome. |
| doi_str_mv | 10.1161/ATVBAHA.107.154831 |
| format | Article |
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METHODS AND RESULTS—We analyzed the association between CVD or subclinical atherosclerosis and serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations of 1018 men with the follow-up time of 10 years. MMP-8 concentrations or MMP-8/TIMP-1 ratios were higher in men with prevalent CVD or subclinical atherosclerosis at baseline than those without. In men free of CVD at baseline, MMP-8 concentrations associated with acute myocardial infarction, death from coronary heart disease (CHD), CVD, or from any cause with relative risks (RR) (95% CI) of 1.138 (1.009 to 1.284), 1.188 (1.034 to 1.365), 1.171 (1.026 to 1.338), and 1.136 (1.018 to 1.269), respectively, and MMP-8/TIMP-1 ratio with CHD death with an RR of 1.206 (1.028 to 1.414) per standard deviation (SD) increase. In men with no prevalent CVD but with subclinical atherosclerosis at baseline, elevated serum MMP-8 concentration predicted CVD death with an RR of 3.03 (1.09 to 8.44). TIMP-1 concentrations alone had no predictive value.
CONCLUSIONS—The results indicate that serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.107.154831</identifier><identifier>PMID: 17932311</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Associated diseases and complications ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - blood ; Atherosclerosis - complications ; Atherosclerosis - mortality ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Coronary Disease - blood ; Coronary Disease - etiology ; Diabetes. Impaired glucose tolerance ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Finland - epidemiology ; Follow-Up Studies ; Humans ; Linear Models ; Male ; Matrix Metalloproteinase 8 - blood ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - etiology ; Neuropharmacology ; Pharmacology. Drug treatments ; Prevalence ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Risk Assessment ; Risk Factors ; ROC Curve ; Survival Analysis ; Time Factors ; Tissue Inhibitor of Metalloproteinase-1 - blood</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2007-12, Vol.27 (12), p.2722-2728</ispartof><rights>2007 American Heart Association, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4571-b817446c945b61d50d7515c3817c620506cd8f2030ca58f68b12cfa5de736473</citedby><cites>FETCH-LOGICAL-c4571-b817446c945b61d50d7515c3817c620506cd8f2030ca58f68b12cfa5de736473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19872741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17932311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuomainen, Anita M</creatorcontrib><creatorcontrib>Nyyssönen, Kristiina</creatorcontrib><creatorcontrib>Laukkanen, Jari A</creatorcontrib><creatorcontrib>Tervahartiala, Taina</creatorcontrib><creatorcontrib>Tuomainen, Tomi-Pekka</creatorcontrib><creatorcontrib>Salonen, Jukka T</creatorcontrib><creatorcontrib>Sorsa, Timo</creatorcontrib><creatorcontrib>Pussinen, Pirkko J</creatorcontrib><title>Serum Matrix Metalloproteinase-8 Concentrations Are Associated With Cardiovascular Outcome in Men</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—In culture studies matrix metalloproteinase (MMP)-8 thins the protecting fibrous cap of the atherosclerotic plaque thereby increasing its vulnerability. Results on the association of serum MMP-8 concentrations and cardiovascular diseases (CVD) are, however, scarce and contradictory.
METHODS AND RESULTS—We analyzed the association between CVD or subclinical atherosclerosis and serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations of 1018 men with the follow-up time of 10 years. MMP-8 concentrations or MMP-8/TIMP-1 ratios were higher in men with prevalent CVD or subclinical atherosclerosis at baseline than those without. In men free of CVD at baseline, MMP-8 concentrations associated with acute myocardial infarction, death from coronary heart disease (CHD), CVD, or from any cause with relative risks (RR) (95% CI) of 1.138 (1.009 to 1.284), 1.188 (1.034 to 1.365), 1.171 (1.026 to 1.338), and 1.136 (1.018 to 1.269), respectively, and MMP-8/TIMP-1 ratio with CHD death with an RR of 1.206 (1.028 to 1.414) per standard deviation (SD) increase. In men with no prevalent CVD but with subclinical atherosclerosis at baseline, elevated serum MMP-8 concentration predicted CVD death with an RR of 3.03 (1.09 to 8.44). TIMP-1 concentrations alone had no predictive value.
CONCLUSIONS—The results indicate that serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome.</description><subject>Associated diseases and complications</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - mortality</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - etiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Finland - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Matrix Metalloproteinase 8 - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - etiology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - blood</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0Eoh_wBzggX-CWxePP7DGsoEVq1QMrOEZeZ6I1OHGxHQr_HsNG6o2Tx6Nn3hk9hLwCtgHQ8K7bf3nfXXcbYGYDSrYCnpBzUFw2Ugv9tNbMbBulJT8jFzl_Y4xJztlzcgZmK7gAOCf2M6Zlore2JP-L3mKxIcT7FAv62WZsWrqLs8O5JFt8nDPtEtIu5-i8LTjQr74c6c6mwcefNrsl2ETvluLihNTPNXB-QZ6NNmR8ub6XZP_xw3533dzcXX3adTeNk8pAc2jBSKndVqqDhkGxwShQTtS205wppt3QjpwJ5qxqR90egLvRqgGN0NKIS_L2FFuP_7FgLv3ks8MQ7Ixxyb1ulRBKQgX5CXQp5pxw7O-Tn2z63QPr_3rtV6_1b_qT1zr0ek1fDhMOjyOryAq8WYFqwYYx2dn5_MhtW8PNv-36xD3EUDDl72F5wNQf0YZy_N8FfwDugpGN</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Tuomainen, Anita M</creator><creator>Nyyssönen, Kristiina</creator><creator>Laukkanen, Jari A</creator><creator>Tervahartiala, Taina</creator><creator>Tuomainen, Tomi-Pekka</creator><creator>Salonen, Jukka T</creator><creator>Sorsa, Timo</creator><creator>Pussinen, Pirkko J</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>Serum Matrix Metalloproteinase-8 Concentrations Are Associated With Cardiovascular Outcome in Men</title><author>Tuomainen, Anita M ; Nyyssönen, Kristiina ; Laukkanen, Jari A ; Tervahartiala, Taina ; Tuomainen, Tomi-Pekka ; Salonen, Jukka T ; Sorsa, Timo ; Pussinen, Pirkko J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4571-b817446c945b61d50d7515c3817c620506cd8f2030ca58f68b12cfa5de736473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Associated diseases and complications</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - mortality</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - etiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Finland - epidemiology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Matrix Metalloproteinase 8 - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - etiology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuomainen, Anita M</creatorcontrib><creatorcontrib>Nyyssönen, Kristiina</creatorcontrib><creatorcontrib>Laukkanen, Jari A</creatorcontrib><creatorcontrib>Tervahartiala, Taina</creatorcontrib><creatorcontrib>Tuomainen, Tomi-Pekka</creatorcontrib><creatorcontrib>Salonen, Jukka T</creatorcontrib><creatorcontrib>Sorsa, Timo</creatorcontrib><creatorcontrib>Pussinen, Pirkko J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuomainen, Anita M</au><au>Nyyssönen, Kristiina</au><au>Laukkanen, Jari A</au><au>Tervahartiala, Taina</au><au>Tuomainen, Tomi-Pekka</au><au>Salonen, Jukka T</au><au>Sorsa, Timo</au><au>Pussinen, Pirkko J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Matrix Metalloproteinase-8 Concentrations Are Associated With Cardiovascular Outcome in Men</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2007-12</date><risdate>2007</risdate><volume>27</volume><issue>12</issue><spage>2722</spage><epage>2728</epage><pages>2722-2728</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>OBJECTIVE—In culture studies matrix metalloproteinase (MMP)-8 thins the protecting fibrous cap of the atherosclerotic plaque thereby increasing its vulnerability. Results on the association of serum MMP-8 concentrations and cardiovascular diseases (CVD) are, however, scarce and contradictory.
METHODS AND RESULTS—We analyzed the association between CVD or subclinical atherosclerosis and serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations of 1018 men with the follow-up time of 10 years. MMP-8 concentrations or MMP-8/TIMP-1 ratios were higher in men with prevalent CVD or subclinical atherosclerosis at baseline than those without. In men free of CVD at baseline, MMP-8 concentrations associated with acute myocardial infarction, death from coronary heart disease (CHD), CVD, or from any cause with relative risks (RR) (95% CI) of 1.138 (1.009 to 1.284), 1.188 (1.034 to 1.365), 1.171 (1.026 to 1.338), and 1.136 (1.018 to 1.269), respectively, and MMP-8/TIMP-1 ratio with CHD death with an RR of 1.206 (1.028 to 1.414) per standard deviation (SD) increase. In men with no prevalent CVD but with subclinical atherosclerosis at baseline, elevated serum MMP-8 concentration predicted CVD death with an RR of 3.03 (1.09 to 8.44). TIMP-1 concentrations alone had no predictive value.
CONCLUSIONS—The results indicate that serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>17932311</pmid><doi>10.1161/ATVBAHA.107.154831</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Associated diseases and complications Atherosclerosis (general aspects, experimental research) Atherosclerosis - blood Atherosclerosis - complications Atherosclerosis - mortality Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Coronary Disease - blood Coronary Disease - etiology Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Finland - epidemiology Follow-Up Studies Humans Linear Models Male Matrix Metalloproteinase 8 - blood Medical sciences Middle Aged Myocardial Infarction - blood Myocardial Infarction - etiology Neuropharmacology Pharmacology. Drug treatments Prevalence Prognosis Proportional Hazards Models Prospective Studies Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Risk Assessment Risk Factors ROC Curve Survival Analysis Time Factors Tissue Inhibitor of Metalloproteinase-1 - blood |
| title | Serum Matrix Metalloproteinase-8 Concentrations Are Associated With Cardiovascular Outcome in Men |
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