Co-activation of P2Y2 receptor and TRPV channel by ATP: implications for ATP induced pain

1. Extracellular ATP is recognized as a peripheral modulator of pain. Activation of ionotropic P2X receptors in sensory neurons has been implicated in induction of pain, whereas metabotropic P2Y receptors in potentiation of pain induced by chemical or physical stimuli via capsaicin sensitive TRPV1 c...

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Veröffentlicht in:	Cellular and molecular neurobiology 2005-08, Vol.25 (5), p.819-832
Hauptverfasser:	Lakshmi, Srihasam, Joshi, Preeti G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Calcium - metabolism Capsaicin - pharmacology Cell Line Dose-Response Relationship, Drug Hyperalgesia - metabolism Ion Channels - metabolism Mice Neurons - cytology Neurons - drug effects Neurons - metabolism Pain - metabolism Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y2 TRPV Cation Channels
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