Evaluation of Chemical and Antiviral Properties of Essential Oils from South American Plants
The essential oils of seven aromatic plants from Córdoba, San Luis and San Juan Provinces (Argentina) were isolated by steam distillation and analysed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex...
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| Veröffentlicht in: | Antiviral chemistry & chemotherapy 2005-08, Vol.16 (4), p.247-251 |
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| creator | Duschatzky, Claudia B Possetto, Mirta L Talarico, Laura B García, Cybele C Michis, Fabiana Almeida, Norma V de Lampasona, Marina P Schuff, Carola Damonte, Elsa B |
| description | The essential oils of seven aromatic plants from Córdoba, San Luis and San Juan Provinces (Argentina) were isolated by steam distillation and analysed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and antivirus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound. |
| doi_str_mv | 10.1177/095632020501600404 |
| format | Article |
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The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and antivirus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound.</description><identifier>ISSN: 2040-2066</identifier><identifier>ISSN: 0956-3202</identifier><identifier>EISSN: 2040-2066</identifier><identifier>DOI: 10.1177/095632020501600404</identifier><identifier>PMID: 16130522</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral activity ; Antiviral agents ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Antiviral drugs ; Argentina ; Biological and medical sciences ; Chemical composition ; Cytotoxicity ; Dengue fever ; Dengue Virus - drug effects ; Distillation ; Essential oils ; Gas chromatography ; General pharmacology ; Herpes simplex ; Herpesvirus 1, Human - drug effects ; Junin virus - drug effects ; Mass spectrometry ; Mass spectroscopy ; Medical sciences ; Oils & fats ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Oils - chemistry ; Plant Oils - pharmacology ; Steam ; Vector-borne diseases ; Virions</subject><ispartof>Antiviral chemistry & chemotherapy, 2005-08, Vol.16 (4), p.247-251</ispartof><rights>2005 SAGE Publications</rights><rights>2005 INIST-CNRS</rights><rights>2005 SAGE Publications. 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The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and antivirus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound.</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral activity</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral drugs</subject><subject>Argentina</subject><subject>Biological and medical sciences</subject><subject>Chemical composition</subject><subject>Cytotoxicity</subject><subject>Dengue fever</subject><subject>Dengue Virus - drug effects</subject><subject>Distillation</subject><subject>Essential oils</subject><subject>Gas chromatography</subject><subject>General pharmacology</subject><subject>Herpes simplex</subject><subject>Herpesvirus 1, Human - drug effects</subject><subject>Junin virus - drug effects</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical sciences</subject><subject>Oils & fats</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and antivirus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>16130522</pmid><doi>10.1177/095632020501600404</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Argentina Biological and medical sciences Chemical composition Cytotoxicity Dengue fever Dengue Virus - drug effects Distillation Essential oils Gas chromatography General pharmacology Herpes simplex Herpesvirus 1, Human - drug effects Junin virus - drug effects Mass spectrometry Mass spectroscopy Medical sciences Oils & fats Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Oils - chemistry Plant Oils - pharmacology Steam Vector-borne diseases Virions |
| title | Evaluation of Chemical and Antiviral Properties of Essential Oils from South American Plants |
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