Prediction of Mortality and Need for Neonatal Extracorporeal Membrane Oxygenation in Fetuses with Congenital Diaphragmatic Hernia: Logistic Regression Analysis Based on MRI Fetal Lung Volume Measurements
The purpose of this study was to use logistic regression analysis of prenatal MRI fetal lung volume measurements to calculate mortality and the need for extracorporeal membrane oxygenation (ECMO) therapy among fetuses with congenital diaphragmatic hernia (CDH). The fetal lung volume measurements of...
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| Veröffentlicht in: | American journal of roentgenology (1976) 2007-12, Vol.189 (6), p.1307-1311 |
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| container_title | American journal of roentgenology (1976) |
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| creator | Neff, K. Wolfgang Kilian, A. Kristina Schaible, Thomas Schutz, Eva-Maria Busing, Karen A |
| description | The purpose of this study was to use logistic regression analysis of prenatal MRI fetal lung volume measurements to calculate mortality and the need for extracorporeal membrane oxygenation (ECMO) therapy among fetuses with congenital diaphragmatic hernia (CDH).
The fetal lung volume measurements of 65 fetuses with CDH were obtained between 32 and 34 weeks' gestation by means of MRI performed with multiplanar T2-weighted HASTE and true fast imaging with steady-state precession sequences. Logistic regression analysis was used to assess the prognostic value of the fetal lung volume measurements for prenatal prediction of fetal survival and need for neonatal ECMO.
Fetal lung volume was a highly significant predictor of survival (p < 0.0001) and neonatal ECMO requirement (p = 0.0006). The mortality was 84% and the ECMO requirement 80% among fetuses with a lung volume of 5 mL. The mortality was 0.4% and the ECMO requirement 20% among patients with a fetal lung volume of 30 mL.
Logistic regression analysis of MRI fetal lung volume measurements is highly valuable in predicting mortality among neonates with CDH, and it may help to estimate the need for neonatal ECMO. The method is feasible for facilitating parental guidance and may help in choosing postnatal therapeutic options, including ECMO therapy. |
| doi_str_mv | 10.2214/AJR.07.2434 |
| format | Article |
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The fetal lung volume measurements of 65 fetuses with CDH were obtained between 32 and 34 weeks' gestation by means of MRI performed with multiplanar T2-weighted HASTE and true fast imaging with steady-state precession sequences. Logistic regression analysis was used to assess the prognostic value of the fetal lung volume measurements for prenatal prediction of fetal survival and need for neonatal ECMO.
Fetal lung volume was a highly significant predictor of survival (p < 0.0001) and neonatal ECMO requirement (p = 0.0006). The mortality was 84% and the ECMO requirement 80% among fetuses with a lung volume of 5 mL. The mortality was 0.4% and the ECMO requirement 20% among patients with a fetal lung volume of 30 mL.
Logistic regression analysis of MRI fetal lung volume measurements is highly valuable in predicting mortality among neonates with CDH, and it may help to estimate the need for neonatal ECMO. The method is feasible for facilitating parental guidance and may help in choosing postnatal therapeutic options, including ECMO therapy.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/AJR.07.2434</identifier><identifier>PMID: 18029863</identifier><identifier>CODEN: AAJRDX</identifier><language>eng</language><publisher>Leesburg, VA: Am Roentgen Ray Soc</publisher><subject>Biological and medical sciences ; Extracorporeal Membrane Oxygenation - mortality ; Female ; Fetal Monitoring - statistics & numerical data ; Germany - epidemiology ; Hernia, Diaphragmatic - diagnosis ; Hernia, Diaphragmatic - mortality ; Hernia, Diaphragmatic - prevention & control ; Hernias, Diaphragmatic, Congenital ; Humans ; Imaging, Three-Dimensional - statistics & numerical data ; Investigative techniques of respiratory function ; Investigative techniques, diagnostic techniques (general aspects) ; Logistic Models ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; Medical sciences ; Prevalence ; Prognosis ; Regression Analysis ; Risk Assessment - methods ; Risk Factors ; Survival Analysis ; Survival Rate ; Tidal Volume</subject><ispartof>American journal of roentgenology (1976), 2007-12, Vol.189 (6), p.1307-1311</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-2acafa416d14c43f75212ddde8e56147daf9592e87824e7c22b83195b07246e83</citedby><cites>FETCH-LOGICAL-c349t-2acafa416d14c43f75212ddde8e56147daf9592e87824e7c22b83195b07246e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4106,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19880282$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18029863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neff, K. Wolfgang</creatorcontrib><creatorcontrib>Kilian, A. Kristina</creatorcontrib><creatorcontrib>Schaible, Thomas</creatorcontrib><creatorcontrib>Schutz, Eva-Maria</creatorcontrib><creatorcontrib>Busing, Karen A</creatorcontrib><title>Prediction of Mortality and Need for Neonatal Extracorporeal Membrane Oxygenation in Fetuses with Congenital Diaphragmatic Hernia: Logistic Regression Analysis Based on MRI Fetal Lung Volume Measurements</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>The purpose of this study was to use logistic regression analysis of prenatal MRI fetal lung volume measurements to calculate mortality and the need for extracorporeal membrane oxygenation (ECMO) therapy among fetuses with congenital diaphragmatic hernia (CDH).
The fetal lung volume measurements of 65 fetuses with CDH were obtained between 32 and 34 weeks' gestation by means of MRI performed with multiplanar T2-weighted HASTE and true fast imaging with steady-state precession sequences. Logistic regression analysis was used to assess the prognostic value of the fetal lung volume measurements for prenatal prediction of fetal survival and need for neonatal ECMO.
Fetal lung volume was a highly significant predictor of survival (p < 0.0001) and neonatal ECMO requirement (p = 0.0006). The mortality was 84% and the ECMO requirement 80% among fetuses with a lung volume of 5 mL. The mortality was 0.4% and the ECMO requirement 20% among patients with a fetal lung volume of 30 mL.
Logistic regression analysis of MRI fetal lung volume measurements is highly valuable in predicting mortality among neonates with CDH, and it may help to estimate the need for neonatal ECMO. The method is feasible for facilitating parental guidance and may help in choosing postnatal therapeutic options, including ECMO therapy.</description><subject>Biological and medical sciences</subject><subject>Extracorporeal Membrane Oxygenation - mortality</subject><subject>Female</subject><subject>Fetal Monitoring - statistics & numerical data</subject><subject>Germany - epidemiology</subject><subject>Hernia, Diaphragmatic - diagnosis</subject><subject>Hernia, Diaphragmatic - mortality</subject><subject>Hernia, Diaphragmatic - prevention & control</subject><subject>Hernias, Diaphragmatic, Congenital</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - statistics & numerical data</subject><subject>Investigative techniques of respiratory function</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Logistic Models</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Tidal Volume</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU2P0zAQhiMEYsvCiTvyBTigFn8lcfZWyi67qGVRBYib5TqT1CiJiydRtr-RP4WjVtqT7ZnHj0bzJslrRhecM_lx-XW7oPmCSyGfJDOWymwumGRPkxkVGZsrKn5fJC8Q_1BKc1Xkz5MLpigvVCZmyb_vAUpne-c74iuy8aE3jeuPxHQl-QZQksqHePGdiQ1y_dAHY304-ADxuYF2F0wH5P7hWENEJo3ryA30AwKS0fV7svJd7Lnp-2dnDvtg6jaSltxC6Jy5ImtfO5wKW6gDIE6SZWeaIzoknwzGIWJls72bvNGyHrqa_PLN0EKcwOAQoIWux5fJs8o0CK_O52Xy8-b6x-p2vr7_crdarudWyKKfc2NNZSTLSiatFFWecsbLsgQFacZkXpqqSAsOKldcQm453ynBinRHcy4zUOIyeXfyHoL_OwD2unVooWniJvyAOlOpYEKxCH44gTZ4xACVPgTXmnDUjOopOx2z0zTXU3aRfnPWDrsWykf2HFYE3p4Bg9Y0Vdy8dfjIFSqSikfu_Ynbu3o_ugAaW9M0Ucv0OI5MFTrTTNBc_AfAuLKe</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Neff, K. Wolfgang</creator><creator>Kilian, A. Kristina</creator><creator>Schaible, Thomas</creator><creator>Schutz, Eva-Maria</creator><creator>Busing, Karen A</creator><general>Am Roentgen Ray Soc</general><general>American Roentgen Ray Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Prediction of Mortality and Need for Neonatal Extracorporeal Membrane Oxygenation in Fetuses with Congenital Diaphragmatic Hernia: Logistic Regression Analysis Based on MRI Fetal Lung Volume Measurements</title><author>Neff, K. Wolfgang ; Kilian, A. Kristina ; Schaible, Thomas ; Schutz, Eva-Maria ; Busing, Karen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-2acafa416d14c43f75212ddde8e56147daf9592e87824e7c22b83195b07246e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Extracorporeal Membrane Oxygenation - mortality</topic><topic>Female</topic><topic>Fetal Monitoring - statistics & numerical data</topic><topic>Germany - epidemiology</topic><topic>Hernia, Diaphragmatic - diagnosis</topic><topic>Hernia, Diaphragmatic - mortality</topic><topic>Hernia, Diaphragmatic - prevention & control</topic><topic>Hernias, Diaphragmatic, Congenital</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - statistics & numerical data</topic><topic>Investigative techniques of respiratory function</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Logistic Models</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Tidal Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neff, K. Wolfgang</creatorcontrib><creatorcontrib>Kilian, A. Kristina</creatorcontrib><creatorcontrib>Schaible, Thomas</creatorcontrib><creatorcontrib>Schutz, Eva-Maria</creatorcontrib><creatorcontrib>Busing, Karen A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neff, K. Wolfgang</au><au>Kilian, A. Kristina</au><au>Schaible, Thomas</au><au>Schutz, Eva-Maria</au><au>Busing, Karen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of Mortality and Need for Neonatal Extracorporeal Membrane Oxygenation in Fetuses with Congenital Diaphragmatic Hernia: Logistic Regression Analysis Based on MRI Fetal Lung Volume Measurements</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>189</volume><issue>6</issue><spage>1307</spage><epage>1311</epage><pages>1307-1311</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><coden>AAJRDX</coden><abstract>The purpose of this study was to use logistic regression analysis of prenatal MRI fetal lung volume measurements to calculate mortality and the need for extracorporeal membrane oxygenation (ECMO) therapy among fetuses with congenital diaphragmatic hernia (CDH).
The fetal lung volume measurements of 65 fetuses with CDH were obtained between 32 and 34 weeks' gestation by means of MRI performed with multiplanar T2-weighted HASTE and true fast imaging with steady-state precession sequences. Logistic regression analysis was used to assess the prognostic value of the fetal lung volume measurements for prenatal prediction of fetal survival and need for neonatal ECMO.
Fetal lung volume was a highly significant predictor of survival (p < 0.0001) and neonatal ECMO requirement (p = 0.0006). The mortality was 84% and the ECMO requirement 80% among fetuses with a lung volume of 5 mL. The mortality was 0.4% and the ECMO requirement 20% among patients with a fetal lung volume of 30 mL.
Logistic regression analysis of MRI fetal lung volume measurements is highly valuable in predicting mortality among neonates with CDH, and it may help to estimate the need for neonatal ECMO. The method is feasible for facilitating parental guidance and may help in choosing postnatal therapeutic options, including ECMO therapy.</abstract><cop>Leesburg, VA</cop><pub>Am Roentgen Ray Soc</pub><pmid>18029863</pmid><doi>10.2214/AJR.07.2434</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Extracorporeal Membrane Oxygenation - mortality Female Fetal Monitoring - statistics & numerical data Germany - epidemiology Hernia, Diaphragmatic - diagnosis Hernia, Diaphragmatic - mortality Hernia, Diaphragmatic - prevention & control Hernias, Diaphragmatic, Congenital Humans Imaging, Three-Dimensional - statistics & numerical data Investigative techniques of respiratory function Investigative techniques, diagnostic techniques (general aspects) Logistic Models Magnetic Resonance Imaging - statistics & numerical data Male Medical sciences Prevalence Prognosis Regression Analysis Risk Assessment - methods Risk Factors Survival Analysis Survival Rate Tidal Volume |
| title | Prediction of Mortality and Need for Neonatal Extracorporeal Membrane Oxygenation in Fetuses with Congenital Diaphragmatic Hernia: Logistic Regression Analysis Based on MRI Fetal Lung Volume Measurements |
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