Hypoxia-Induced Mediators of Stem/Progenitor Cell Trafficking Are Increased in Children With Hemangioma

OBJECTIVE—The mechanism of neovascularization during the proliferative phase of infantile hemangioma is poorly understood. It is known that circulating bone marrow-derived endothelial progenitor cells (EPCs) form new blood vessels in ischemic tissues using mediators regulated by the transcription fa...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-12, Vol.27 (12), p.2664-2670
Hauptverfasser:	Kleinman, Mark E, Greives, Matthew R, Churgin, Samara S, Blechman, Keith M, Chang, Eric I, Ceradini, Daniel J, Tepper, Oren M, Gurtner, Geoffrey C
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenic Proteins - genetics Angiogenic Proteins - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Case-Control Studies Cell Hypoxia Cell Movement Cell Proliferation Cells, Cultured Chemokine CXCL12 - metabolism Child, Preschool Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug toxicity and drugs side effects treatment Endothelial Cells - enzymology Endothelial Cells - metabolism Endothelial Cells - pathology Estrogens - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic Hemangioma - genetics Hemangioma - metabolism Hemangioma - pathology Humans Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Infant Male Matrix Metalloproteinase 9 - blood Matrix Metalloproteinase 9 - metabolism Medical sciences Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pharmacology. Drug treatments Receptors, Estrogen - metabolism RNA, Messenger - metabolism Stem Cells - enzymology Stem Cells - metabolism Stem Cells - pathology Toxicity: blood Up-Regulation Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - metabolism Vertebrates: cardiovascular system
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