Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches
Abstract Time domain analysis of electroencephalography (EEG) can identify subsecond periods of quasi-stable brain states. These so-called microstates assumingly correspond to basic units of cognition and emotion. On the other hand, Global Field Synchronization (GFS) is a frequency domain measure to...
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description | Abstract Time domain analysis of electroencephalography (EEG) can identify subsecond periods of quasi-stable brain states. These so-called microstates assumingly correspond to basic units of cognition and emotion. On the other hand, Global Field Synchronization (GFS) is a frequency domain measure to estimate functional synchronization of brain processes on a global level for each EEG frequency band [Koenig, T., Lehmann, D., Saito, N., Kuginuki, T., Kinoshita, T., Koukkou, M., 2001. Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results. Schizophr Res. 50, 55-60.]. Using these time and frequency domain analyzes, several previous studies reported shortened microstate duration in specific microstate classes and decreased GFS in theta band in drug naïve schizophrenia compared to controls. The purpose of this study was to investigate changes of these EEG parameters after drug treatment in drug naïve schizophrenia. EEG analysis was performed in 21 drug-naive patients and 21 healthy controls. 14 patients were reevaluated 2–8 weeks (mean 4.3) after the initiation of drug administration. The results extended findings of treatment effect on brain functions in schizophrenia, and imply that shortened duration of specific microstate classes seems a state marker especially in patients with later neuroleptic responsive, while lower theta GFS seems a state-related phenomenon and that higher gamma GFS is a trait like phenomenon. |
doi_str_mv | 10.1016/j.schres.2007.07.012 |
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These so-called microstates assumingly correspond to basic units of cognition and emotion. On the other hand, Global Field Synchronization (GFS) is a frequency domain measure to estimate functional synchronization of brain processes on a global level for each EEG frequency band [Koenig, T., Lehmann, D., Saito, N., Kuginuki, T., Kinoshita, T., Koukkou, M., 2001. Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results. Schizophr Res. 50, 55-60.]. Using these time and frequency domain analyzes, several previous studies reported shortened microstate duration in specific microstate classes and decreased GFS in theta band in drug naïve schizophrenia compared to controls. The purpose of this study was to investigate changes of these EEG parameters after drug treatment in drug naïve schizophrenia. EEG analysis was performed in 21 drug-naive patients and 21 healthy controls. 14 patients were reevaluated 2–8 weeks (mean 4.3) after the initiation of drug administration. The results extended findings of treatment effect on brain functions in schizophrenia, and imply that shortened duration of specific microstate classes seems a state marker especially in patients with later neuroleptic responsive, while lower theta GFS seems a state-related phenomenon and that higher gamma GFS is a trait like phenomenon.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2007.07.012</identifier><identifier>PMID: 17703921</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Brain Mapping ; Brief Psychiatric Rating Scale ; Cerebral Cortex - drug effects ; Cortical Synchronization - drug effects ; EEG microstate ; Electroencephalography - drug effects ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Non-responder ; Prognosis ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Reference Values ; Responder ; Schizophrenia ; Schizophrenia - drug therapy ; Signal Processing, Computer-Assisted ; Synchronization ; Treatment ; Treatment Outcome</subject><ispartof>Schizophrenia research, 2007-12, Vol.97 (1), p.163-172</ispartof><rights>Elsevier B.V.</rights><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-59f6b60de4bc1aa8191ea73ec41170386348ce9aa1b65c23e1f0c26fcfd60a113</citedby><cites>FETCH-LOGICAL-c511t-59f6b60de4bc1aa8191ea73ec41170386348ce9aa1b65c23e1f0c26fcfd60a113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0920996407003106$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19866424$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17703921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kikuchi, Mitsuru</creatorcontrib><creatorcontrib>Koenig, Thomas</creatorcontrib><creatorcontrib>Wada, Yuji</creatorcontrib><creatorcontrib>Higashima, Masato</creatorcontrib><creatorcontrib>Koshino, Yoshifumi</creatorcontrib><creatorcontrib>Strik, Werner</creatorcontrib><creatorcontrib>Dierks, Thomas</creatorcontrib><title>Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Time domain analysis of electroencephalography (EEG) can identify subsecond periods of quasi-stable brain states. These so-called microstates assumingly correspond to basic units of cognition and emotion. On the other hand, Global Field Synchronization (GFS) is a frequency domain measure to estimate functional synchronization of brain processes on a global level for each EEG frequency band [Koenig, T., Lehmann, D., Saito, N., Kuginuki, T., Kinoshita, T., Koukkou, M., 2001. Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results. Schizophr Res. 50, 55-60.]. Using these time and frequency domain analyzes, several previous studies reported shortened microstate duration in specific microstate classes and decreased GFS in theta band in drug naïve schizophrenia compared to controls. The purpose of this study was to investigate changes of these EEG parameters after drug treatment in drug naïve schizophrenia. EEG analysis was performed in 21 drug-naive patients and 21 healthy controls. 14 patients were reevaluated 2–8 weeks (mean 4.3) after the initiation of drug administration. The results extended findings of treatment effect on brain functions in schizophrenia, and imply that shortened duration of specific microstate classes seems a state marker especially in patients with later neuroleptic responsive, while lower theta GFS seems a state-related phenomenon and that higher gamma GFS is a trait like phenomenon.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cortical Synchronization - drug effects</subject><subject>EEG microstate</subject><subject>Electroencephalography - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non-responder</subject><subject>Prognosis</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Reference Values</subject><subject>Responder</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Synchronization</subject><subject>Treatment</subject><subject>Treatment Outcome</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksGK1EAQhhtR3HH0DURy0VvGqu6kM_EgLMu4CoseXM9NTafC9ph0YneyML6UD-GL2XEGFrwIBXX566-fr0qIlwgbBNRvD5to7wLHjQSoNkuhfCRWWFYqlyXUj8UKagl5XeviQjyL8QAAWEL1VFxgVYGqJa5E_EyTu-dst7vOyDfZFJimnv2UcduynWLmfOZ5DkPH4-Rs7un3r6RPu93PYUwBvLPZmEzSTHyX3bqe_xq1gX_M7O0xa4aekgmNYxjI3nF8Lp601EV-ce5r8e3D7vbqY37z5frT1eVNbkvEKS_rVu81NFzsLRJtsUamSrEtEFP8rVbF1nJNhHtdWqkYW7BSt7ZtNBCiWos3J9-0OGWJk-ldtNx15HmYo9HbUoFKvNaiOAltGGIM3JoxuJ7C0SCYBbY5mBNss8A2S6FMY6_O_vO-5-Zh6Ew3CV6fBRQtdW0gb1180NVbrQtZJN37k44TjXvHIW1LPC03LqQbmGZw_0vyr4HtXDoMdd_5yPEwzMEn0gZNlAbM1-Uxlr-ACkAhaPUHUSu2iQ</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Kikuchi, Mitsuru</creator><creator>Koenig, Thomas</creator><creator>Wada, Yuji</creator><creator>Higashima, Masato</creator><creator>Koshino, Yoshifumi</creator><creator>Strik, Werner</creator><creator>Dierks, Thomas</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches</title><author>Kikuchi, Mitsuru ; Koenig, Thomas ; Wada, Yuji ; Higashima, Masato ; Koshino, Yoshifumi ; Strik, Werner ; Dierks, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-59f6b60de4bc1aa8191ea73ec41170386348ce9aa1b65c23e1f0c26fcfd60a113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cortical Synchronization - drug effects</topic><topic>EEG microstate</topic><topic>Electroencephalography - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non-responder</topic><topic>Prognosis</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reference Values</topic><topic>Responder</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Synchronization</topic><topic>Treatment</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Mitsuru</creatorcontrib><creatorcontrib>Koenig, Thomas</creatorcontrib><creatorcontrib>Wada, Yuji</creatorcontrib><creatorcontrib>Higashima, Masato</creatorcontrib><creatorcontrib>Koshino, Yoshifumi</creatorcontrib><creatorcontrib>Strik, Werner</creatorcontrib><creatorcontrib>Dierks, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikuchi, Mitsuru</au><au>Koenig, Thomas</au><au>Wada, Yuji</au><au>Higashima, Masato</au><au>Koshino, Yoshifumi</au><au>Strik, Werner</au><au>Dierks, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>97</volume><issue>1</issue><spage>163</spage><epage>172</epage><pages>163-172</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Time domain analysis of electroencephalography (EEG) can identify subsecond periods of quasi-stable brain states. These so-called microstates assumingly correspond to basic units of cognition and emotion. On the other hand, Global Field Synchronization (GFS) is a frequency domain measure to estimate functional synchronization of brain processes on a global level for each EEG frequency band [Koenig, T., Lehmann, D., Saito, N., Kuginuki, T., Kinoshita, T., Koukkou, M., 2001. Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results. Schizophr Res. 50, 55-60.]. Using these time and frequency domain analyzes, several previous studies reported shortened microstate duration in specific microstate classes and decreased GFS in theta band in drug naïve schizophrenia compared to controls. The purpose of this study was to investigate changes of these EEG parameters after drug treatment in drug naïve schizophrenia. EEG analysis was performed in 21 drug-naive patients and 21 healthy controls. 14 patients were reevaluated 2–8 weeks (mean 4.3) after the initiation of drug administration. The results extended findings of treatment effect on brain functions in schizophrenia, and imply that shortened duration of specific microstate classes seems a state marker especially in patients with later neuroleptic responsive, while lower theta GFS seems a state-related phenomenon and that higher gamma GFS is a trait like phenomenon.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17703921</pmid><doi>10.1016/j.schres.2007.07.012</doi><tpages>10</tpages></addata></record> |
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subjects | Adolescent Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Biological and medical sciences Brain Mapping Brief Psychiatric Rating Scale Cerebral Cortex - drug effects Cortical Synchronization - drug effects EEG microstate Electroencephalography - drug effects Female Humans Male Medical sciences Middle Aged Non-responder Prognosis Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reference Values Responder Schizophrenia Schizophrenia - drug therapy Signal Processing, Computer-Assisted Synchronization Treatment Treatment Outcome |
title | Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches |
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