Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches

Abstract Time domain analysis of electroencephalography (EEG) can identify subsecond periods of quasi-stable brain states. These so-called microstates assumingly correspond to basic units of cognition and emotion. On the other hand, Global Field Synchronization (GFS) is a frequency domain measure to...

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Veröffentlicht in:Schizophrenia research 2007-12, Vol.97 (1), p.163-172
Hauptverfasser: Kikuchi, Mitsuru, Koenig, Thomas, Wada, Yuji, Higashima, Masato, Koshino, Yoshifumi, Strik, Werner, Dierks, Thomas
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container_end_page 172
container_issue 1
container_start_page 163
container_title Schizophrenia research
container_volume 97
creator Kikuchi, Mitsuru
Koenig, Thomas
Wada, Yuji
Higashima, Masato
Koshino, Yoshifumi
Strik, Werner
Dierks, Thomas
description Abstract Time domain analysis of electroencephalography (EEG) can identify subsecond periods of quasi-stable brain states. These so-called microstates assumingly correspond to basic units of cognition and emotion. On the other hand, Global Field Synchronization (GFS) is a frequency domain measure to estimate functional synchronization of brain processes on a global level for each EEG frequency band [Koenig, T., Lehmann, D., Saito, N., Kuginuki, T., Kinoshita, T., Koukkou, M., 2001. Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results. Schizophr Res. 50, 55-60.]. Using these time and frequency domain analyzes, several previous studies reported shortened microstate duration in specific microstate classes and decreased GFS in theta band in drug naïve schizophrenia compared to controls. The purpose of this study was to investigate changes of these EEG parameters after drug treatment in drug naïve schizophrenia. EEG analysis was performed in 21 drug-naive patients and 21 healthy controls. 14 patients were reevaluated 2–8 weeks (mean 4.3) after the initiation of drug administration. The results extended findings of treatment effect on brain functions in schizophrenia, and imply that shortened duration of specific microstate classes seems a state marker especially in patients with later neuroleptic responsive, while lower theta GFS seems a state-related phenomenon and that higher gamma GFS is a trait like phenomenon.
doi_str_mv 10.1016/j.schres.2007.07.012
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EEG analysis was performed in 21 drug-naive patients and 21 healthy controls. 14 patients were reevaluated 2–8 weeks (mean 4.3) after the initiation of drug administration. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reference Values</topic><topic>Responder</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Synchronization</topic><topic>Treatment</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Mitsuru</creatorcontrib><creatorcontrib>Koenig, Thomas</creatorcontrib><creatorcontrib>Wada, Yuji</creatorcontrib><creatorcontrib>Higashima, Masato</creatorcontrib><creatorcontrib>Koshino, Yoshifumi</creatorcontrib><creatorcontrib>Strik, Werner</creatorcontrib><creatorcontrib>Dierks, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikuchi, Mitsuru</au><au>Koenig, Thomas</au><au>Wada, Yuji</au><au>Higashima, Masato</au><au>Koshino, Yoshifumi</au><au>Strik, Werner</au><au>Dierks, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>97</volume><issue>1</issue><spage>163</spage><epage>172</epage><pages>163-172</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Time domain analysis of electroencephalography (EEG) can identify subsecond periods of quasi-stable brain states. 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subjects Adolescent
Adult
Adult and adolescent clinical studies
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Brain Mapping
Brief Psychiatric Rating Scale
Cerebral Cortex - drug effects
Cortical Synchronization - drug effects
EEG microstate
Electroencephalography - drug effects
Female
Humans
Male
Medical sciences
Middle Aged
Non-responder
Prognosis
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reference Values
Responder
Schizophrenia
Schizophrenia - drug therapy
Signal Processing, Computer-Assisted
Synchronization
Treatment
Treatment Outcome
title Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: Time and frequency domain approaches
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