Nanostructures from alkyl vitamin C derivatives (ASC n ): Properties and potential platform for drug delivery
Alkyl vitamin C derivatives (ASC n ) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASC n depend on the length of n-alkyl fatty chain. ASC n start to aggregate at temperatures (CMT, Krafft point) in...
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| Veröffentlicht in: | International journal of pharmaceutics 2007-12, Vol.345 (1), p.26-34 |
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| container_title | International journal of pharmaceutics |
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| creator | Palma, Santiago Manzo, Ruben Lo Nostro, Pierandrea Allemandi, Daniel |
| description | Alkyl vitamin C derivatives (ASC
n
) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASC
n
depend on the length of
n-alkyl fatty chain. ASC
n
start to aggregate at temperatures (CMT, Krafft point) in which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASC
n
can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC
12, ASC
14 and ASC
16) liquid-crystal structures named coagels are obtained. They are able to solubilized insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin. Besides, the rheological properties of the coagels would be adequate for topical administration of pharmaceutical. These systems possess very interesting properties making ASC
n
coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties are described and analyzed. Also, the perspectives of these systems as drug delivery systems are discussed. |
| doi_str_mv | 10.1016/j.ijpharm.2007.09.014 |
| format | Article |
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n
) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASC
n
depend on the length of
n-alkyl fatty chain. ASC
n
start to aggregate at temperatures (CMT, Krafft point) in which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASC
n
can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC
12, ASC
14 and ASC
16) liquid-crystal structures named coagels are obtained. They are able to solubilized insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin. Besides, the rheological properties of the coagels would be adequate for topical administration of pharmaceutical. These systems possess very interesting properties making ASC
n
coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties are described and analyzed. Also, the perspectives of these systems as drug delivery systems are discussed.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2007.09.014</identifier><identifier>PMID: 17964094</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Ascorbic Acid - administration & dosage ; Ascorbic Acid - analogs & derivatives ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Pharmaceutical ; Chemistry, Physical ; Coagel ; Drug delivery ; Drug Delivery Systems ; General pharmacology ; Humans ; Medical sciences ; Nanostructures ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Rheology ; Skin Absorption ; Vitamin C ; Vitamins - administration & dosage</subject><ispartof>International journal of pharmaceutics, 2007-12, Vol.345 (1), p.26-34</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-67100baf293cdc20470891e99145df32bf6e213dc0228e5ef895af3757f3690f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2007.09.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19865991$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17964094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palma, Santiago</creatorcontrib><creatorcontrib>Manzo, Ruben</creatorcontrib><creatorcontrib>Lo Nostro, Pierandrea</creatorcontrib><creatorcontrib>Allemandi, Daniel</creatorcontrib><title>Nanostructures from alkyl vitamin C derivatives (ASC n ): Properties and potential platform for drug delivery</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Alkyl vitamin C derivatives (ASC
n
) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASC
n
depend on the length of
n-alkyl fatty chain. ASC
n
start to aggregate at temperatures (CMT, Krafft point) in which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASC
n
can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC
12, ASC
14 and ASC
16) liquid-crystal structures named coagels are obtained. They are able to solubilized insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin. Besides, the rheological properties of the coagels would be adequate for topical administration of pharmaceutical. These systems possess very interesting properties making ASC
n
coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties are described and analyzed. Also, the perspectives of these systems as drug delivery systems are discussed.</description><subject>Animals</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - analogs & derivatives</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chemistry, Physical</subject><subject>Coagel</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nanostructures</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Rheology</subject><subject>Skin Absorption</subject><subject>Vitamin C</subject><subject>Vitamins - administration & dosage</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rFDEUhoModm39CUpuFL2Y8WQymUx6I2WpVShaUK9DNnOiWeerSWZh_70pO9DL3uRAeN7z8RDyhkHJgDWf9qXfz39NGMoKQJagSmD1M7JhreQFr2XznGyAy7YQTPIz8irGPQA0FeMvyRmTqqlB1RsyfDfjFFNYbFoCRurCNFDT_zv29OCTGfxIt7TD4A8m-UMGPlz93NKRfrykd2GaMSSfP83Y0XlKOCZvejr3JrkpDDQ_tAvLn9ygz-FwvCAvnOkjvl7rOfn95frX9mtx--Pm2_bqtrC1UKloJAPYGVcpbjtbQS2hVQyVYrXoHK92rsF8SGehqloU6FoljONSSMcbBY6fk_envnOY7heMSQ8-Wux7M-K0RN20olK1EBkUJ9CGKcaATs_BDyYcNQP94Fnv9epZP3jWoHT2nHNv1wHLbsDuMbWKzcC7FTDRmt4FM1ofHznVNiLfk7nPJw6zjoPHoKP1OFrsfECbdDf5J1b5D5IHnuE</recordid><startdate>20071210</startdate><enddate>20071210</enddate><creator>Palma, Santiago</creator><creator>Manzo, Ruben</creator><creator>Lo Nostro, Pierandrea</creator><creator>Allemandi, Daniel</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071210</creationdate><title>Nanostructures from alkyl vitamin C derivatives (ASC n ): Properties and potential platform for drug delivery</title><author>Palma, Santiago ; Manzo, Ruben ; Lo Nostro, Pierandrea ; Allemandi, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-67100baf293cdc20470891e99145df32bf6e213dc0228e5ef895af3757f3690f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Ascorbic Acid - analogs & derivatives</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chemistry, Physical</topic><topic>Coagel</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nanostructures</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Rheology</topic><topic>Skin Absorption</topic><topic>Vitamin C</topic><topic>Vitamins - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palma, Santiago</creatorcontrib><creatorcontrib>Manzo, Ruben</creatorcontrib><creatorcontrib>Lo Nostro, Pierandrea</creatorcontrib><creatorcontrib>Allemandi, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palma, Santiago</au><au>Manzo, Ruben</au><au>Lo Nostro, Pierandrea</au><au>Allemandi, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanostructures from alkyl vitamin C derivatives (ASC n ): Properties and potential platform for drug delivery</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2007-12-10</date><risdate>2007</risdate><volume>345</volume><issue>1</issue><spage>26</spage><epage>34</epage><pages>26-34</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Alkyl vitamin C derivatives (ASC
n
) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASC
n
depend on the length of
n-alkyl fatty chain. ASC
n
start to aggregate at temperatures (CMT, Krafft point) in which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASC
n
can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC
12, ASC
14 and ASC
16) liquid-crystal structures named coagels are obtained. They are able to solubilized insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin. Besides, the rheological properties of the coagels would be adequate for topical administration of pharmaceutical. These systems possess very interesting properties making ASC
n
coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties are described and analyzed. Also, the perspectives of these systems as drug delivery systems are discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17964094</pmid><doi>10.1016/j.ijpharm.2007.09.014</doi><tpages>9</tpages></addata></record> |
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| ispartof | International journal of pharmaceutics, 2007-12, Vol.345 (1), p.26-34 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Ascorbic Acid - administration & dosage Ascorbic Acid - analogs & derivatives Biological and medical sciences Chemical Phenomena Chemistry, Pharmaceutical Chemistry, Physical Coagel Drug delivery Drug Delivery Systems General pharmacology Humans Medical sciences Nanostructures Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rheology Skin Absorption Vitamin C Vitamins - administration & dosage |
| title | Nanostructures from alkyl vitamin C derivatives (ASC n ): Properties and potential platform for drug delivery |
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