Oxygen carriers and cancer chemo- and radiotherapy sensitization: Bench to bedside and back
Summary After over a century of preclinical and clinical development, a number of artificial oxygen carriers based either on perfluorochemicals or hemoglobins are currently in advanced clinical trials for their ability to replace red blood cells and to ensure adequate tissue oxygenation in case of a...
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| Veröffentlicht in: | Cancer treatment reviews 2007-12, Vol.33 (8), p.757-761 |
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| container_title | Cancer treatment reviews |
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| creator | Yu, Minghua Dai, Min Liu, Qian Xiu, Ruijuan |
| description | Summary After over a century of preclinical and clinical development, a number of artificial oxygen carriers based either on perfluorochemicals or hemoglobins are currently in advanced clinical trials for their ability to replace red blood cells and to ensure adequate tissue oxygenation in case of acute anemia or infarction. On the other hand, intravenous administration of perflourocarbone emulsions or hemoglobin solutions were effective in increasing the oxygenation throughout experimental tumors, and fueled by exciting new developments in the field, some products are experimentally and clinically investigated as cancer chemo- and radiosensitizing agents. This review is to provide a first overview of the current status of artificial oxygen carriers as a oxygen therapeutics in cancer chemo- and radiotherapy sensitization. |
| doi_str_mv | 10.1016/j.ctrv.2007.08.002 |
| format | Article |
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On the other hand, intravenous administration of perflourocarbone emulsions or hemoglobin solutions were effective in increasing the oxygenation throughout experimental tumors, and fueled by exciting new developments in the field, some products are experimentally and clinically investigated as cancer chemo- and radiosensitizing agents. This review is to provide a first overview of the current status of artificial oxygen carriers as a oxygen therapeutics in cancer chemo- and radiotherapy sensitization.</description><identifier>ISSN: 0305-7372</identifier><identifier>EISSN: 1532-1967</identifier><identifier>DOI: 10.1016/j.ctrv.2007.08.002</identifier><identifier>PMID: 17936507</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Blood Substitutes - pharmacology ; Cancer therapy ; Cell Hypoxia - drug effects ; Clinical Trials as Topic ; Drug resistance ; Hematology, Oncology and Palliative Medicine ; Humans ; Hypoxia ; Neoplasms - drug therapy ; Neoplasms - radiotherapy ; Oxygen carriers ; Radiation sensitizing agents ; Radiation-Sensitizing Agents - pharmacology</subject><ispartof>Cancer treatment reviews, 2007-12, Vol.33 (8), p.757-761</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-8c930a8e0d4b673a77f97cbd7622cf3568797e58a7672e3180b8258d8cd699f83</citedby><cites>FETCH-LOGICAL-c475t-8c930a8e0d4b673a77f97cbd7622cf3568797e58a7672e3180b8258d8cd699f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ctrv.2007.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17936507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Minghua</creatorcontrib><creatorcontrib>Dai, Min</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Xiu, Ruijuan</creatorcontrib><title>Oxygen carriers and cancer chemo- and radiotherapy sensitization: Bench to bedside and back</title><title>Cancer treatment reviews</title><addtitle>Cancer Treat Rev</addtitle><description>Summary After over a century of preclinical and clinical development, a number of artificial oxygen carriers based either on perfluorochemicals or hemoglobins are currently in advanced clinical trials for their ability to replace red blood cells and to ensure adequate tissue oxygenation in case of acute anemia or infarction. 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This review is to provide a first overview of the current status of artificial oxygen carriers as a oxygen therapeutics in cancer chemo- and radiotherapy sensitization.</description><subject>Animals</subject><subject>Blood Substitutes - pharmacology</subject><subject>Cancer therapy</subject><subject>Cell Hypoxia - drug effects</subject><subject>Clinical Trials as Topic</subject><subject>Drug resistance</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - radiotherapy</subject><subject>Oxygen carriers</subject><subject>Radiation sensitizing agents</subject><subject>Radiation-Sensitizing Agents - pharmacology</subject><issn>0305-7372</issn><issn>1532-1967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9rFDEUxYModl39Aj7IPPk2403SSTIigi22CoU-qCD4EDLJHTfb2WRNZku3n95Md0HwoU_3D-ccuL9LyGsKDQUq3q0bO6XbhgHIBlQDwJ6QBW05q2kn5FOyAA5tLblkJ-RFzmsA6LjonpMTKkvTglyQX9d3-98YKmtS8phyZYIrQ7CYKrvCTawfNsk4H6cVJrPdVxlD9pO_N5OP4X11hsGuqilWPbrsHT4YemNvXpJngxkzvjrWJflx8fn7-Zf66vry6_mnq9qeynaqle04GIXgTnshuZFy6KTtnRSM2YG3QslOYquMFJIhpwp6xVrllHWi6wbFl-TtIXeb4p8d5klvfLY4jiZg3GUtVMuUKNFLwg5Cm2LOCQe9TX5j0l5T0DNSvdYzUj0j1aB0QVpMb47pu36D7p_lyLAIPhwEWG68LRB1tr4wQecT2km76B_P__if3Y4-eGvGG9xjXsddCoWepjozDfrb_NT5pyABKJU_-V_xiJyF</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Yu, Minghua</creator><creator>Dai, Min</creator><creator>Liu, Qian</creator><creator>Xiu, Ruijuan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Oxygen carriers and cancer chemo- and radiotherapy sensitization: Bench to bedside and back</title><author>Yu, Minghua ; Dai, Min ; Liu, Qian ; Xiu, Ruijuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-8c930a8e0d4b673a77f97cbd7622cf3568797e58a7672e3180b8258d8cd699f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Blood Substitutes - pharmacology</topic><topic>Cancer therapy</topic><topic>Cell Hypoxia - drug effects</topic><topic>Clinical Trials as Topic</topic><topic>Drug resistance</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - radiotherapy</topic><topic>Oxygen carriers</topic><topic>Radiation sensitizing agents</topic><topic>Radiation-Sensitizing Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Minghua</creatorcontrib><creatorcontrib>Dai, Min</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Xiu, Ruijuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer treatment reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Minghua</au><au>Dai, Min</au><au>Liu, Qian</au><au>Xiu, Ruijuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen carriers and cancer chemo- and radiotherapy sensitization: Bench to bedside and back</atitle><jtitle>Cancer treatment reviews</jtitle><addtitle>Cancer Treat Rev</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>33</volume><issue>8</issue><spage>757</spage><epage>761</epage><pages>757-761</pages><issn>0305-7372</issn><eissn>1532-1967</eissn><abstract>Summary After over a century of preclinical and clinical development, a number of artificial oxygen carriers based either on perfluorochemicals or hemoglobins are currently in advanced clinical trials for their ability to replace red blood cells and to ensure adequate tissue oxygenation in case of acute anemia or infarction. 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| fulltext | fulltext |
| identifier | ISSN: 0305-7372 |
| ispartof | Cancer treatment reviews, 2007-12, Vol.33 (8), p.757-761 |
| issn | 0305-7372 1532-1967 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Blood Substitutes - pharmacology Cancer therapy Cell Hypoxia - drug effects Clinical Trials as Topic Drug resistance Hematology, Oncology and Palliative Medicine Humans Hypoxia Neoplasms - drug therapy Neoplasms - radiotherapy Oxygen carriers Radiation sensitizing agents Radiation-Sensitizing Agents - pharmacology |
| title | Oxygen carriers and cancer chemo- and radiotherapy sensitization: Bench to bedside and back |
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