Functional disconnectivity in subjects at high genetic risk of schizophrenia

Schizophrenia is a highly heritable psychotic disorder. It has been suggested that deficits of the established state arise from abnormal interactions between brain regions. We sought to examine whether such connectivity abnormalities would be present in subjects at high genetic risk for the disorder...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2005-09, Vol.128 (9), p.2097-2108
Hauptverfasser:	Whalley, Heather C., Simonotto, Enrico, Marshall, Ian, Owens, David G. C., Goddard, Nigel H., Johnstone, Eve C., Lawrie, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult BA = Broadmann area Biological and medical sciences Brain Mapping - methods Cerebellum - physiopathology Child clinical studies connectivity Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Developmental disorders DLPFC = dorsolateral prefrontal cortex EHRS = Edinburgh High Risk Study fMRI fMRI = functional MRI Genetic Predisposition to Disease high risk HRF = haemodynamic response function Humans Infantile autism IPL = inferior parietal lobule Magnetic Resonance Imaging - methods MedFG = medial frontal gyrus Medical sciences Neural Pathways - physiopathology Neurology Neuropsychological Tests Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotic Disorders - genetics Psychotic Disorders - physiopathology Psychotic Disorders - psychology S/MTG = superior/middle temporal gyrus schizophrenia Schizophrenia - genetics Schizophrenia - physiopathology Temporal Lobe - physiopathology
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