Coenzyme Q10 Protects From Aging-Related Oxidative Stress and Improves Mitochondrial Function in Heart of Rats Fed a Polyunsaturated Fatty Acid (PUFA)-Rich Diet
Coenzyme Q10 supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q10....
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2005-08, Vol.60 (8), p.970-975 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Ochoa, Julio J. Quiles, José L. Huertas, Jesús R. Mataix, José |
| description | Coenzyme Q10 supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q10. Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, α-tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a3, b, c+c1 and cytochrome c oxidase activity were measured. Coenzyme Q10-supplemented animals showed lower hydroperoxide levels; higher content and/or activity of α-tocopherol, coenzyme Q, and catalase; and a slightly lower decrease in mitochondrial function. According to that, previously reported positive effects of coenzyme Q supplementation on the life span of rats fed a PUFA-rich diet might be a consequence, at least in part, of a lower oxidative stress level and perhaps, to a minor extent, of a smaller decrease in mitochondrial function. |
| doi_str_mv | 10.1093/gerona/60.8.970 |
| format | Article |
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Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q10. Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, α-tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a3, b, c+c1 and cytochrome c oxidase activity were measured. Coenzyme Q10-supplemented animals showed lower hydroperoxide levels; higher content and/or activity of α-tocopherol, coenzyme Q, and catalase; and a slightly lower decrease in mitochondrial function. 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Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Coenzyme Q10 supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q10. Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, α-tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a3, b, c+c1 and cytochrome c oxidase activity were measured. Coenzyme Q10-supplemented animals showed lower hydroperoxide levels; higher content and/or activity of α-tocopherol, coenzyme Q, and catalase; and a slightly lower decrease in mitochondrial function. 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Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2005-08</date><risdate>2005</risdate><volume>60</volume><issue>8</issue><spage>970</spage><epage>975</epage><pages>970-975</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Coenzyme Q10 supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q10. Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, α-tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a3, b, c+c1 and cytochrome c oxidase activity were measured. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aging - drug effects Aging - metabolism alpha-Tocopherol - metabolism Animals Catalase - metabolism Coenzymes Dietary Fats, Unsaturated - administration & dosage Electron Transport Complex IV - metabolism Fatty Acids, Unsaturated - administration & dosage Glutathione Peroxidase - metabolism Lipid Peroxides - metabolism Male Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Oxidative Stress - drug effects Rats Rats, Wistar Ubiquinone - analogs & derivatives Ubiquinone - metabolism Ubiquinone - pharmacology |
| title | Coenzyme Q10 Protects From Aging-Related Oxidative Stress and Improves Mitochondrial Function in Heart of Rats Fed a Polyunsaturated Fatty Acid (PUFA)-Rich Diet |
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