Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis

The application of disease-regulated promoters in local gene therapy for rheumatoid arthritis potentiates the development of a sophisticated treatment that relies on a restricted and fine-tuned supply of biologicals. Although several studies have investigated regulated promoters for achieving effect...

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Veröffentlicht in:	Gene therapy 2007-12, Vol.14 (23), p.1632-1638
Hauptverfasser:	Geurts, J, Arntz, O J, Bennink, M B, Joosten, L A B, van den Berg, W B, van de Loo, F A J
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - drug effects 3T3 Cells - immunology Adenoviridae - genetics Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Arthritis Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Experimental - therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment Cartilage Cartilage, Articular - immunology Cartilage, Articular - pathology Cell Biology Collagen Cytokines Enhancer Elements, Genetic Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Health aspects Health. Pharmaceutical industry Hindlimb Human Genetics Humans Industrial applications and implications. Economical aspects Inflammation Injections, Intra-Articular Interleukin 1 Interleukin 4 Interleukin 6 Interleukin-1 - genetics Interleukin-4 - genetics Interleukin-4 - pharmacology Interleukin-6 - genetics Interleukins Joint diseases Knee Lipopolysaccharides - pharmacology Luciferases - genetics Medical sciences Mice Mice, Inbred DBA Nanotechnology original-article Physiological aspects Promoter Regions, Genetic Promoters Promoters (Genetics) Rheumatoid arthritis Risk factors Safety Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes
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