Quantitative determination of endogenous sorbitol and fructose in human erythrocytes by atmospheric-pressure chemical ionization LC tandem mass spectrometry

Evaluation of different extraction methods for quantification of endogenous sorbitol and fructose in human red blood cells (RBCs) and matrix effects in ESI and APCI showed that protein-precipitation followed by mixed-mode solid-phase extraction was more effective extraction method and APCI more effe...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-09, Vol.824 (1), p.36-44
Hauptverfasser:	Liang, H.R., Takagaki, T., Foltz, R.L., Bennett, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Atmospheric Pressure Biological and medical sciences Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Endogenous sorbitol and fructose Erythrocytes - chemistry Fructose - blood Fructose - chemistry Fructose - standards Fundamental and applied biological sciences. Psychology General pharmacology Human red blood cells Humans LC/APCI-MS/MS Matrix effects Medical sciences Mixed-mode solid-phase extraction Pharmacology. Drug treatments Reference Standards Reproducibility of Results Sorbitol - blood Sorbitol - chemistry Sorbitol - standards Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods Stereoisomerism
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container_title	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
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creator	Liang, H.R. Takagaki, T. Foltz, R.L. Bennett, P.
description	Evaluation of different extraction methods for quantification of endogenous sorbitol and fructose in human red blood cells (RBCs) and matrix effects in ESI and APCI showed that protein-precipitation followed by mixed-mode solid-phase extraction was more effective extraction method and APCI more effective ionization method. Then the LC/APCI-MS/MS method was fully validated and successfully applied to analysis of clinical RBC samples. The concentrations of endogenous sorbitol and fructose were determined using calibration curves employing sorbitiol- 13C 6 and fructose- 13C 6 as surrogate analytes. The method has provided excellent intra- and inter-assay precision and accuracy with a linear range of 50.0–10,000 ng/mL (correlation coefficient >0.999) for sorbitol- 13C 6 and 250–50000 ng/mL (correlation coefficient >0.999) for fructose- 13C 6 in human RBCs.
doi_str_mv	10.1016/j.jchromb.2005.05.020
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Then the LC/APCI-MS/MS method was fully validated and successfully applied to analysis of clinical RBC samples. The concentrations of endogenous sorbitol and fructose were determined using calibration curves employing sorbitiol- 13C 6 and fructose- 13C 6 as surrogate analytes. The method has provided excellent intra- and inter-assay precision and accuracy with a linear range of 50.0–10,000 ng/mL (correlation coefficient >0.999) for sorbitol- 13C 6 and 250–50000 ng/mL (correlation coefficient >0.999) for fructose- 13C 6 in human RBCs.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2005.05.020</identifier><identifier>PMID: 16061433</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Atmospheric Pressure ; Biological and medical sciences ; Chromatography, Liquid - instrumentation ; Chromatography, Liquid - methods ; Endogenous sorbitol and fructose ; Erythrocytes - chemistry ; Fructose - blood ; Fructose - chemistry ; Fructose - standards ; Fundamental and applied biological sciences. 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B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>Evaluation of different extraction methods for quantification of endogenous sorbitol and fructose in human red blood cells (RBCs) and matrix effects in ESI and APCI showed that protein-precipitation followed by mixed-mode solid-phase extraction was more effective extraction method and APCI more effective ionization method. Then the LC/APCI-MS/MS method was fully validated and successfully applied to analysis of clinical RBC samples. The concentrations of endogenous sorbitol and fructose were determined using calibration curves employing sorbitiol- 13C 6 and fructose- 13C 6 as surrogate analytes. The method has provided excellent intra- and inter-assay precision and accuracy with a linear range of 50.0–10,000 ng/mL (correlation coefficient >0.999) for sorbitol- 13C 6 and 250–50000 ng/mL (correlation coefficient >0.999) for fructose- 13C 6 in human RBCs.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Atmospheric Pressure</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid - instrumentation</subject><subject>Chromatography, Liquid - methods</subject><subject>Endogenous sorbitol and fructose</subject><subject>Erythrocytes - chemistry</subject><subject>Fructose - blood</subject><subject>Fructose - chemistry</subject><subject>Fructose - standards</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Human red blood cells</subject><subject>Humans</subject><subject>LC/APCI-MS/MS</subject><subject>Matrix effects</subject><subject>Medical sciences</subject><subject>Mixed-mode solid-phase extraction</subject><subject>Pharmacology. 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subjects	Analysis Analytical, structural and metabolic biochemistry Atmospheric Pressure Biological and medical sciences Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Endogenous sorbitol and fructose Erythrocytes - chemistry Fructose - blood Fructose - chemistry Fructose - standards Fundamental and applied biological sciences. Psychology General pharmacology Human red blood cells Humans LC/APCI-MS/MS Matrix effects Medical sciences Mixed-mode solid-phase extraction Pharmacology. Drug treatments Reference Standards Reproducibility of Results Sorbitol - blood Sorbitol - chemistry Sorbitol - standards Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods Stereoisomerism
title	Quantitative determination of endogenous sorbitol and fructose in human erythrocytes by atmospheric-pressure chemical ionization LC tandem mass spectrometry
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