The 19-kDa antigen of Mycobacterium tuberculosis is a major adhesin that binds the mannose receptor of THP-1 monocytic cells and promotes phagocytosis of mycobacteria

Identification of mycobacterial adhesins is needed to understand better the pathogenesis of tuberculosis and to develop new strategies to fight this infection. In this work, THP-1 monocytic cells were incubated with Mycobacterium tuberculosis culture filtrate proteins labelled with biotin and a domi...

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Veröffentlicht in:	Microbial pathogenesis 2005-09, Vol.39 (3), p.97-107
Hauptverfasser:	Diaz-Silvestre, Hugo, Espinosa-Cueto, Patricia, Sanchez-Gonzalez, Alejandro, Esparza-Ceron, Miguel A., Pereira-Suarez, Ana Laura, Bernal-Fernandez, German, Espitia, Clara, Mancilla, Raul
Format:	Artikel
Sprache:	eng
Schlagworte:	19-kDa antigen Acetylglucosamine - pharmacology adhesins Adhesins, Bacterial - immunology Adhesins, Bacterial - metabolism animal pathogenic bacteria Antigens, Bacterial - immunology Bacterial Adhesion bacterial antigens Biological and medical sciences Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology human health Humans Immunoblotting Immunoprecipitation Lectins, C-Type - immunology Lectins, C-Type - metabolism Macrophages Mannans - pharmacology mannose Mannose receptor Mannose-Binding Lectins - immunology Mannose-Binding Lectins - metabolism Methylmannosides - pharmacology Microbiology monocytes Monocytes - immunology Monocytes - metabolism Monocytes - microbiology Mycobacterium smegmatis Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - metabolism Phagocytosis Phagocytosis - immunology protein binding Protein Binding - immunology receptors Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism tuberculosis Tuberculosis - microbiology
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