Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry
The challenging structure and potent growth inhibition properties against a variety of human cancer cell lines make Spongistatin 1 (1) an exciting target for total synthesis. Enantioselective total synthesis has been achieved by exploiting a latent element of pseudo‐symmetry (‐ ‐ ‐ ‐ ‐ =pseudo‐C2 ax...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2005-08, Vol.44 (34), p.5433-5438 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Ball, Matthew Gaunt, Matthew J. Hook, David F. Jessiman, Alan S. Kawahara, Shigeru Orsini, Paolo Scolaro, Alessandra Talbot, Adam C. Tanner, Huw R. Yamanoi, Shigeo Ley, Steven V. |
| description | The challenging structure and potent growth inhibition properties against a variety of human cancer cell lines make Spongistatin 1 (1) an exciting target for total synthesis. Enantioselective total synthesis has been achieved by exploiting a latent element of pseudo‐symmetry (‐ ‐ ‐ ‐ ‐ =pseudo‐C2 axis) within the ABCD bis(spiroketal) fragment (red substructure). |
| doi_str_mv | 10.1002/anie.200502008 |
| format | Article |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological Factors - chemical synthesis Biological Factors - chemistry dithianes Macrolides - chemical synthesis Macrolides - chemistry Molecular Structure natural products pseudo-symmetry spongistatin 1 Stereoisomerism total synthesis |
| title | Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry |
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