A polymorphism in the MTHFD1 gene increases a mother’s risk of having an unexplained second trimester pregnancy loss

Low maternal folate or vitamin B12 status has been implicated in numerous pregnancy complications including spontaneous abortion. The primary aim of this study was to test a polymorphism within the trifunctional folate enzyme MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahy...

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Veröffentlicht in:	Molecular human reproduction 2005-07, Vol.11 (7), p.477-480
Hauptverfasser:	Parle-McDermott, Anne, Pangilinan, Faith, Mills, James L., Signore, Caroline C., Molloy, Anne M., Cotter, Amanda, Conley, Mary, Cox, Christopher, Kirke, Peadar N., Scott, John M., Brody, Lawrence C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aborted Fetus - enzymology abortion Abortion, Spontaneous - genetics Adult Aminohydrolases - genetics Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Female fetal death Formate-Tetrahydrofolate Ligase - genetics Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genotype Humans Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics Multienzyme Complexes - genetics Point Mutation Polymorphism, Genetic Pregnancy Pregnancy Trimester, Second - genetics second trimester spontaneous unexplained
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