A One-Pot Formal [4 + 2] Cycloaddition Approach to Substituted Piperidines, Indolizidines, and Quinolizidines. Total Synthesis of Indolizidine (−)-209I

Heating a mixture of substituted N-benzyl γ-chloropropylamines, conjugated alkynoates or alkynones, sodium carbonate, and a catalytic amount of sodium iodide in i-PrOH at 70−83 °C delivers substituted piperidines in good yields. This transformation goes through a cascade Michael addition/alkylation...

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Veröffentlicht in:	Journal of organic chemistry 2005-09, Vol.70 (18), p.7364-7370
Hauptverfasser:	Yu, Shanghai, Zhu, Wei, Ma, Dawei
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Indolizines - chemical synthesis Organic chemistry Preparations and properties
Online-Zugang:	Volltext
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