Perspectives of biotechnological production of l-tyrosine and its applications
The aromatic amino acid l-tyrosine is used as a dietary supplement and has promise as a valuable precursor compound for various industrial and pharmaceutical applications. In contrast to chemical production, biotechnological methods can produce l-tyrosine from biomass feedstocks under environmentall...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2007-12, Vol.77 (4), p.751-762 |
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| creator | Lütke-Eversloh, Tina Santos, Christine Nicole S Stephanopoulos, Gregory |
| description | The aromatic amino acid l-tyrosine is used as a dietary supplement and has promise as a valuable precursor compound for various industrial and pharmaceutical applications. In contrast to chemical production, biotechnological methods can produce l-tyrosine from biomass feedstocks under environmentally friendly and near carbon-free conditions. In this minireview, various strategies for synthesizing l-tyrosine by employing biocatalysts are discussed, including initial approaches as well as more recent advances. Whereas early attempts to engineer l-tyrosine-excreting microbes were based on auxotrophic and antimetabolite-resistant mutants, recombinant deoxyribonucleic acid technology and a vastly increasing knowledge of bacterial physiology allowed recently for more targeted genetic manipulations and strain improvements. As an alternative route, l-tyrosine can also be obtained from the conversion of phenol, pyruvate, and ammonia or phenol and serine in reactions catalyzed by the enzyme tyrosine phenol lyase. |
| doi_str_mv | 10.1007/s00253-007-1243-y |
| format | Article |
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In contrast to chemical production, biotechnological methods can produce l-tyrosine from biomass feedstocks under environmentally friendly and near carbon-free conditions. In this minireview, various strategies for synthesizing l-tyrosine by employing biocatalysts are discussed, including initial approaches as well as more recent advances. Whereas early attempts to engineer l-tyrosine-excreting microbes were based on auxotrophic and antimetabolite-resistant mutants, recombinant deoxyribonucleic acid technology and a vastly increasing knowledge of bacterial physiology allowed recently for more targeted genetic manipulations and strain improvements. 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In contrast to chemical production, biotechnological methods can produce l-tyrosine from biomass feedstocks under environmentally friendly and near carbon-free conditions. In this minireview, various strategies for synthesizing l-tyrosine by employing biocatalysts are discussed, including initial approaches as well as more recent advances. Whereas early attempts to engineer l-tyrosine-excreting microbes were based on auxotrophic and antimetabolite-resistant mutants, recombinant deoxyribonucleic acid technology and a vastly increasing knowledge of bacterial physiology allowed recently for more targeted genetic manipulations and strain improvements. As an alternative route, l-tyrosine can also be obtained from the conversion of phenol, pyruvate, and ammonia or phenol and serine in reactions catalyzed by the enzyme tyrosine phenol lyase.</description><subject>Amino Acids</subject><subject>Aromatic amino acids</subject><subject>Bacteria - enzymology</subject><subject>Bacteria - genetics</subject><subject>Bacteria - metabolism</subject><subject>Bacterial Physiological Phenomena</subject><subject>Bacterial physiology</subject><subject>Biocatalysts</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Biotechnology - methods</subject><subject>Chemicals</subject><subject>Corynebacterium glutamicum</subject><subject>Dehydrogenases</subject><subject>Dietary supplements</subject><subject>Energy consumption</subject><subject>Engineering</subject><subject>Escherichia coli</subject><subject>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lütke-Eversloh, Tina</au><au>Santos, Christine Nicole S</au><au>Stephanopoulos, Gregory</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perspectives of biotechnological production of l-tyrosine and its applications</atitle><jtitle>Applied microbiology and biotechnology</jtitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>77</volume><issue>4</issue><spage>751</spage><epage>762</epage><pages>751-762</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><coden>AMBIDG</coden><abstract>The aromatic amino acid l-tyrosine is used as a dietary supplement and has promise as a valuable precursor compound for various industrial and pharmaceutical applications. In contrast to chemical production, biotechnological methods can produce l-tyrosine from biomass feedstocks under environmentally friendly and near carbon-free conditions. In this minireview, various strategies for synthesizing l-tyrosine by employing biocatalysts are discussed, including initial approaches as well as more recent advances. Whereas early attempts to engineer l-tyrosine-excreting microbes were based on auxotrophic and antimetabolite-resistant mutants, recombinant deoxyribonucleic acid technology and a vastly increasing knowledge of bacterial physiology allowed recently for more targeted genetic manipulations and strain improvements. As an alternative route, l-tyrosine can also be obtained from the conversion of phenol, pyruvate, and ammonia or phenol and serine in reactions catalyzed by the enzyme tyrosine phenol lyase.</abstract><cop>Berlin</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>17968539</pmid><doi>10.1007/s00253-007-1243-y</doi><tpages>12</tpages></addata></record> |
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| ispartof | Applied microbiology and biotechnology, 2007-12, Vol.77 (4), p.751-762 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Amino Acids Aromatic amino acids Bacteria - enzymology Bacteria - genetics Bacteria - metabolism Bacterial Physiological Phenomena Bacterial physiology Biocatalysts Biological and medical sciences Biotechnology Biotechnology - methods Chemicals Corynebacterium glutamicum Dehydrogenases Dietary supplements Energy consumption Engineering Escherichia coli Fundamental and applied biological sciences. Psychology Genetic Engineering - methods Metabolic engineering Metabolism Metabolites Parkinson's disease Pharmaceuticals Phenols Raw materials Studies tyrosine Tyrosine - biosynthesis Tyrosine phenol lyase Tyrosine Phenol-Lyase - metabolism |
| title | Perspectives of biotechnological production of l-tyrosine and its applications |
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