Chemokine Receptor Expression by Leukemic T Cells of Cutaneous T-Cell Lymphoma: Clinical and Histopathological Correlations

Chemokine receptors expressed by normal and neoplastic lymphocytes provide an important mechanism for cells to traffic into the skin and skin-associated lymph nodes. The goal of this study was to correlate chemokine receptor and CD62L expression by circulating neoplastic T cells with the clinical an...

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Veröffentlicht in:	Journal of investigative dermatology 2007-12, Vol.127 (12), p.2882-2892
Hauptverfasser:	Capriotti, Elisabetta, Vonderheid, Eric C., Thoburn, Christopher J., Bright, Emilie C., Hess, Allan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Differentiation, T-Lymphocyte Antigens, Neoplasm - biosynthesis Biological and medical sciences CC chemokine receptors CCR1 protein CCR7 protein CD62L protein Chemokine receptors CXCR3 protein CXCR5 protein Dermatology Female Flow Cytometry - methods Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Immunologic Memory - immunology Immunological memory Internet L-Selectin - biosynthesis Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph nodes Lymph Nodes - pathology Lymphadenopathy Lymphocytes T Lymphoma, T-Cell, Cutaneous - immunology Lymphoma, T-Cell, Cutaneous - metabolism Male Medical sciences Membrane Glycoproteins - biosynthesis Memory cells Middle Aged Prognosis Receptors, Chemokine - biosynthesis Sezary syndrome Sezary Syndrome - genetics Skin Skin - immunology Skin - pathology T-cell lymphoma T-Lymphocytes - metabolism
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