The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1
The CD155 ligand CD96 is an immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2007-12, Vol.364 (4), p.959-965 |
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| container_issue | 4 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Seth, S. Maier, M.K. Qiu, Q. Ravens, I. Kremmer, E. Förster, R. Bernhardt, G. |
| description | The CD155 ligand CD96 is an immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96 (mCD96) binds to nectin-1, a receptor related to CD155. Applying newly generated monoclonal antibodies specifically recognizing mCD96, an expression profile is revealed resembling closely that of human CD96 (hCD96) on cells of hematopoietic origin. A panel of anti-mCD96 but also recently established anti-mCD155 antibodies effectively prevents formation of CD96/CD155-complexes. This was exploited to demonstrate that the only available receptor for mCD96 present on thymocytes is mCD155. Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. These results suggest a function of the CD96/CD155-adhesion system in T cell biology. |
| doi_str_mv | 10.1016/j.bbrc.2007.10.102 |
| format | Article |
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We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96 (mCD96) binds to nectin-1, a receptor related to CD155. Applying newly generated monoclonal antibodies specifically recognizing mCD96, an expression profile is revealed resembling closely that of human CD96 (hCD96) on cells of hematopoietic origin. A panel of anti-mCD96 but also recently established anti-mCD155 antibodies effectively prevents formation of CD96/CD155-complexes. This was exploited to demonstrate that the only available receptor for mCD96 present on thymocytes is mCD155. Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. 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We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96 (mCD96) binds to nectin-1, a receptor related to CD155. Applying newly generated monoclonal antibodies specifically recognizing mCD96, an expression profile is revealed resembling closely that of human CD96 (hCD96) on cells of hematopoietic origin. A panel of anti-mCD96 but also recently established anti-mCD155 antibodies effectively prevents formation of CD96/CD155-complexes. This was exploited to demonstrate that the only available receptor for mCD96 present on thymocytes is mCD155. Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. These results suggest a function of the CD96/CD155-adhesion system in T cell biology.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Antibody</subject><subject>Antigens, CD - metabolism</subject><subject>CD155</subject><subject>CD96</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Line</subject><subject>Expression</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Membrane Glycoproteins</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Monoclonal antibody</subject><subject>Nectin-1</subject><subject>Nectins</subject><subject>Platelet Glycoprotein GPIb-IX Complex</subject><subject>Rats</subject><subject>Receptors, Virus - metabolism</subject><subject>T cells</subject><subject>T-Lymphocytes - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFqGzEQhkVpSNw0L9BD0Km3dWeklbSCXIqbtIVAenChN7ErzRI59q4jrQN5-2prQ2_taWDm-3-Gj7EPCEsE1J82y65LfikAzPLPTrxhCwQLlUCo37IFAOhKWPx1wd7lvAFArLU9ZxdorEFh5YL9WD8S3x1SHIjv24Gvuaftlu_a9ESJr75YzWPm5dCGR8pxHHgiT_tpTLwfZwCVKufAB_JTHCp8z876dpvp6jQv2c-72_XqW3X_8PX76vN95WWjpqrptdReK2NCbWUjAUVnPPahxbaV0iig2ihBSoLuhe5C-R0hhIaAerJKXrKPx959Gp8PlCe3i3n-vR1oPGSnG4XWWPgviLbRtRa6gOII-jTmnKh3-xSLiFeH4GbhbuNm4W4WftyJEro-tR-6HYW_kZPhAtwcASoyXiIll32kwVOIxeTkwhj_1f8bGsyN3A</recordid><startdate>20071228</startdate><enddate>20071228</enddate><creator>Seth, S.</creator><creator>Maier, M.K.</creator><creator>Qiu, Q.</creator><creator>Ravens, I.</creator><creator>Kremmer, E.</creator><creator>Förster, R.</creator><creator>Bernhardt, G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20071228</creationdate><title>The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1</title><author>Seth, S. ; Maier, M.K. ; Qiu, Q. ; Ravens, I. ; Kremmer, E. ; Förster, R. ; Bernhardt, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-8f636c6577d49383012b7c1fda1aa33750e4752e5306f26bd01110dd8e0efe953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adhesion</topic><topic>Animals</topic><topic>Antibody</topic><topic>Antigens, CD - metabolism</topic><topic>CD155</topic><topic>CD96</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Line</topic><topic>Expression</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Membrane Glycoproteins</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Monoclonal antibody</topic><topic>Nectin-1</topic><topic>Nectins</topic><topic>Platelet Glycoprotein GPIb-IX Complex</topic><topic>Rats</topic><topic>Receptors, Virus - metabolism</topic><topic>T cells</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seth, S.</creatorcontrib><creatorcontrib>Maier, M.K.</creatorcontrib><creatorcontrib>Qiu, Q.</creatorcontrib><creatorcontrib>Ravens, I.</creatorcontrib><creatorcontrib>Kremmer, E.</creatorcontrib><creatorcontrib>Förster, R.</creatorcontrib><creatorcontrib>Bernhardt, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seth, S.</au><au>Maier, M.K.</au><au>Qiu, Q.</au><au>Ravens, I.</au><au>Kremmer, E.</au><au>Förster, R.</au><au>Bernhardt, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2007-12-28</date><risdate>2007</risdate><volume>364</volume><issue>4</issue><spage>959</spage><epage>965</epage><pages>959-965</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The CD155 ligand CD96 is an immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96 (mCD96) binds to nectin-1, a receptor related to CD155. Applying newly generated monoclonal antibodies specifically recognizing mCD96, an expression profile is revealed resembling closely that of human CD96 (hCD96) on cells of hematopoietic origin. A panel of anti-mCD96 but also recently established anti-mCD155 antibodies effectively prevents formation of CD96/CD155-complexes. This was exploited to demonstrate that the only available receptor for mCD96 present on thymocytes is mCD155. Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. These results suggest a function of the CD96/CD155-adhesion system in T cell biology.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17971293</pmid><doi>10.1016/j.bbrc.2007.10.102</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2007-12, Vol.364 (4), p.959-965 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adhesion Animals Antibody Antigens, CD - metabolism CD155 CD96 Cell Adhesion Molecules - metabolism Cell Line Expression Humans Kidney - metabolism Membrane Glycoproteins Membrane Proteins - metabolism Mice Monoclonal antibody Nectin-1 Nectins Platelet Glycoprotein GPIb-IX Complex Rats Receptors, Virus - metabolism T cells T-Lymphocytes - metabolism |
| title | The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1 |
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