Correlation between Inactive Cathepsin D Expression and Retinal Changes in mcd2/mcd2 Transgenic Mice

To investigate the correlation between the presence of the inactive cathepsin D (CatD) and retinal changes in mcd2/mcd2 transgenic mice. Computational modeling was used to examine whether CatD mutants maintain competitive substrate binding. D407 cells were transfected with pcDNACatDM1 or pcDNACatDM2...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2005-09, Vol.46 (9), p.3031-3038
Hauptverfasser:	Zhang, Dan, Brankov, Meliha, Makhija, Mahindra T, Robertson, Terry, Helmerhorst, Erik, Papadimitriou, John M, Rakoczy, Piroska E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - metabolism Biological and medical sciences Blotting, Western Cathepsin D - chemistry Cathepsin D - physiology Computer Simulation Enzyme Precursors - physiology Eye and associated structures. Visual pathways and centers. Vision Fluorescein Angiography Fundamental and applied biological sciences. Psychology Gene Deletion Humans Immunohistochemistry Macular Degeneration - enzymology Macular Degeneration - pathology Mice Mice, Inbred C57BL Mice, Transgenic Molecular Structure Pigment Epithelium of Eye - enzymology Pigment Epithelium of Eye - pathology Reverse Transcriptase Polymerase Chain Reaction Transfection Vertebrates: nervous system and sense organs
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