Efficient Pd-Catalyzed Amination of Heteroaryl Halides

Efficient Pd-Catalyzed Amination of Heteroaryl Halides

The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-h...

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Veröffentlicht in:Organic letters 2005-09, Vol.7 (18), p.3965-3968
Hauptverfasser: Charles, Mark D, Schultz, Phillip, Buchwald, Stephen L
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Catalysis
Combinatorial Chemistry Techniques
Hydrocarbons, Halogenated - chemistry
Molecular Structure
Palladium - chemistry
Phosphines - chemistry
Pyrimidines - chemistry
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Zusammenfassung:The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0514754