Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy

One of the major adverse effects of glucocorticoid therapy is cutaneous atrophy, often followed by the development of resistance to steroids. It is accepted that epithelial stem cells (SCs) located in the hair follicle bulge divide during times of epidermal proliferative need. We determined whether...

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Veröffentlicht in:	Journal of investigative dermatology 2007-12, Vol.127 (12), p.2749-2758
Hauptverfasser:	Chebotaev, Dmitry V., Yemelyanov, Alexander Y., Lavker, Robert M., Budunova, Irina V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - biosynthesis Atrophy - pathology Cell Nucleus - metabolism Cell Proliferation Epidermis - metabolism Epidermis - physiology Epithelial Cells - cytology Epithelial Cells - metabolism Female Glucocorticoids - metabolism Hair Follicle - metabolism Humans Keratinocytes - metabolism Mice Mice, Inbred C57BL Mice, Inbred DBA Receptors, Glucocorticoid - metabolism Regeneration Skin - pathology
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