Host range mutants of Minute Virus of Mice with a single VP2 amino acid change require additional silent mutations that regulate NS2 accumulation

Two host range switch mutants of the immunosuppressive strain of parvovirus Minute Virus of Mice (MVMi) were isolated from plaques on A9 fibroblasts. Both carried a single coding mutation at residue D399 in VP2, to alanine and glycine in hr105 and hr107, respectively, and a second, non-coding, guani...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2005-09, Vol.340 (1), p.143-154
Hauptverfasser:	D'Abramo, Anthony M., Ali, A. Afshan, Wang, Feng, Cotmore, Susan F., Tattersall, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Base Sequence Capsid Proteins - genetics Fibrotropism Genetic Variation Host range Lymphotropism Mice Minute Virus of Mice Minute Virus of Mice - genetics Molecular Sequence Data Mutation NS2 Parvovirus Polymorphism, Single Nucleotide Productive infection Progeny synthesis Restrictive infection Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virus release
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