Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea
Increased carotid intima-media thickness (IMT) and increased serum levels of inflammatory markers, such as C-reactive protein (CRP), interleukin (IL)-6, and IL-18, are associated with an increased risk of cardiovascular and cerebrovascular diseases. The aim of this study was to evaluate whether caro...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2005-09, Vol.172 (5), p.625-630 |
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| creator | Minoguchi, Kenji Yokoe, Takuya Tazaki, Toshiyuki Minoguchi, Hideko Tanaka, Akihiko Oda, Naruhito Okada, Shinji Ohta, Shin Naito, Hirokuni Adachi, Mitsuru |
| description | Increased carotid intima-media thickness (IMT) and increased serum levels of inflammatory markers, such as C-reactive protein (CRP), interleukin (IL)-6, and IL-18, are associated with an increased risk of cardiovascular and cerebrovascular diseases. The aim of this study was to evaluate whether carotid IMT, a useful marker for early atherosclerosis, is associated with these inflammatory markers in patients with obstructive sleep apnea (OSA). Carotid IMT was investigated with ultrasonography in 36 patients with OSA and 16 obese control subjects. Serum levels of CRP, IL-6, and IL-18 were measured at 5:00 A.M. Carotid IMT (p < 0.001) and serum levels of CRP (p < 0.003), IL-6 (p < 0.005), and IL-18 (p < 0.03) of patients with OSA were significantly higher than those of obese control subjects. Carotid IMT was significantly correlated with serum levels of CRP (r = 0.61, p = 0.0001), IL-6 (r = 0.41, p = 0.01), and IL-18 (r = 0.45, p = 0.005), duration of OSA-related hypoxia (r = 0.60, p = 0.0001), and severity of OSA (r = 0.50, p = 0.002). In addition, the primary factor influencing carotid IMT was duration of hypoxia during total sleep time (p = 0.036). These results suggest that OSA-related hypoxia and systemic inflammation might be associated with the progression of atherosclerosis and thus might increase the risks of cardiovascular and cerebrovascular morbidity in patients with OSA. |
| doi_str_mv | 10.1164/rccm.200412-1652OC |
| format | Article |
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The aim of this study was to evaluate whether carotid IMT, a useful marker for early atherosclerosis, is associated with these inflammatory markers in patients with obstructive sleep apnea (OSA). Carotid IMT was investigated with ultrasonography in 36 patients with OSA and 16 obese control subjects. Serum levels of CRP, IL-6, and IL-18 were measured at 5:00 A.M. Carotid IMT (p < 0.001) and serum levels of CRP (p < 0.003), IL-6 (p < 0.005), and IL-18 (p < 0.03) of patients with OSA were significantly higher than those of obese control subjects. Carotid IMT was significantly correlated with serum levels of CRP (r = 0.61, p = 0.0001), IL-6 (r = 0.41, p = 0.01), and IL-18 (r = 0.45, p = 0.005), duration of OSA-related hypoxia (r = 0.60, p = 0.0001), and severity of OSA (r = 0.50, p = 0.002). In addition, the primary factor influencing carotid IMT was duration of hypoxia during total sleep time (p = 0.036). These results suggest that OSA-related hypoxia and systemic inflammation might be associated with the progression of atherosclerosis and thus might increase the risks of cardiovascular and cerebrovascular morbidity in patients with OSA.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200412-1652OC</identifier><identifier>PMID: 16120716</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers - blood ; Body Weights and Measures ; C-Reactive Protein - analysis ; Carotid Arteries - diagnostic imaging ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - immunology ; Chronic obstructive pulmonary disease, asthma ; Emergency and intensive care: infection, septic shock ; Humans ; Intensive care medicine ; Interleukin-18 - blood ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; Obesity - blood ; Obesity - complications ; Obesity - immunology ; Pneumology ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - immunology ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography</subject><ispartof>American journal of respiratory and critical care medicine, 2005-09, Vol.172 (5), p.625-630</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright American Thoracic Society Sep 1, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-4e6470253fc2b23eea7debe0e0c9922c093f84d4f525d01b1e4d84e120f2c593</citedby><cites>FETCH-LOGICAL-c507t-4e6470253fc2b23eea7debe0e0c9922c093f84d4f525d01b1e4d84e120f2c593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4011,4012,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17102072$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16120716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minoguchi, Kenji</creatorcontrib><creatorcontrib>Yokoe, Takuya</creatorcontrib><creatorcontrib>Tazaki, Toshiyuki</creatorcontrib><creatorcontrib>Minoguchi, Hideko</creatorcontrib><creatorcontrib>Tanaka, Akihiko</creatorcontrib><creatorcontrib>Oda, Naruhito</creatorcontrib><creatorcontrib>Okada, Shinji</creatorcontrib><creatorcontrib>Ohta, Shin</creatorcontrib><creatorcontrib>Naito, Hirokuni</creatorcontrib><creatorcontrib>Adachi, Mitsuru</creatorcontrib><title>Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Increased carotid intima-media thickness (IMT) and increased serum levels of inflammatory markers, such as C-reactive protein (CRP), interleukin (IL)-6, and IL-18, are associated with an increased risk of cardiovascular and cerebrovascular diseases. The aim of this study was to evaluate whether carotid IMT, a useful marker for early atherosclerosis, is associated with these inflammatory markers in patients with obstructive sleep apnea (OSA). Carotid IMT was investigated with ultrasonography in 36 patients with OSA and 16 obese control subjects. Serum levels of CRP, IL-6, and IL-18 were measured at 5:00 A.M. Carotid IMT (p < 0.001) and serum levels of CRP (p < 0.003), IL-6 (p < 0.005), and IL-18 (p < 0.03) of patients with OSA were significantly higher than those of obese control subjects. Carotid IMT was significantly correlated with serum levels of CRP (r = 0.61, p = 0.0001), IL-6 (r = 0.41, p = 0.01), and IL-18 (r = 0.45, p = 0.005), duration of OSA-related hypoxia (r = 0.60, p = 0.0001), and severity of OSA (r = 0.50, p = 0.002). In addition, the primary factor influencing carotid IMT was duration of hypoxia during total sleep time (p = 0.036). These results suggest that OSA-related hypoxia and systemic inflammation might be associated with the progression of atherosclerosis and thus might increase the risks of cardiovascular and cerebrovascular morbidity in patients with OSA.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Body Weights and Measures</subject><subject>C-Reactive Protein - analysis</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - immunology</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - immunology</subject><subject>Pneumology</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - immunology</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0E1v2yAYwHE0rVq7dl9ghwlN2qQd3PJgMPaxivYSqVUOzWE3hOHxQmrjDOxO_fYlcqRKO8HhxwP8CfkI7BqgEjfR2uGaMyaAF1BJvlm9IRcgS1mIRrG3ec9UWQjR_D4n71PaMwa8BvaOnEMFnCmoLki7DjaiSejoysRx8o6uw-QHU9yj84Zud94-BkyJmuDoA8Z5yKDrzTCYaYzP9N7ER4yJ-kA3bZribCf_hPShRzzQ20NAc0XOOtMn_HBaL8n2x_ft6ldxt_m5Xt3eFVYyNRUCK6EYl2VnectLRKMctsiQ2abh3LKm7GrhRCe5dAxaQOFqgfkjHbeyKS_J12XsIY5_Z0yTHnyy2Pcm4DgnXdUSJC-rDD__B_fjHEN-moamqaBsVJ0RX5CNY0oRO32IuUp81sD0sb4-1tdLfb3Uz4c-nSbP7YDu9cgpdwZfTsAka_oummB9enUKWIY8u2-L2_k_u38-ok6D6fs8FrTZH28GxbXUVc71AsNKnAA</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Minoguchi, Kenji</creator><creator>Yokoe, Takuya</creator><creator>Tazaki, Toshiyuki</creator><creator>Minoguchi, Hideko</creator><creator>Tanaka, Akihiko</creator><creator>Oda, Naruhito</creator><creator>Okada, Shinji</creator><creator>Ohta, Shin</creator><creator>Naito, Hirokuni</creator><creator>Adachi, Mitsuru</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea</title><author>Minoguchi, Kenji ; Yokoe, Takuya ; Tazaki, Toshiyuki ; Minoguchi, Hideko ; Tanaka, Akihiko ; Oda, Naruhito ; Okada, Shinji ; Ohta, Shin ; Naito, Hirokuni ; Adachi, Mitsuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-4e6470253fc2b23eea7debe0e0c9922c093f84d4f525d01b1e4d84e120f2c593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Body Weights and Measures</topic><topic>C-Reactive Protein - analysis</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - immunology</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Interleukin-18 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - immunology</topic><topic>Pneumology</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - immunology</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minoguchi, Kenji</creatorcontrib><creatorcontrib>Yokoe, Takuya</creatorcontrib><creatorcontrib>Tazaki, Toshiyuki</creatorcontrib><creatorcontrib>Minoguchi, Hideko</creatorcontrib><creatorcontrib>Tanaka, Akihiko</creatorcontrib><creatorcontrib>Oda, Naruhito</creatorcontrib><creatorcontrib>Okada, Shinji</creatorcontrib><creatorcontrib>Ohta, Shin</creatorcontrib><creatorcontrib>Naito, Hirokuni</creatorcontrib><creatorcontrib>Adachi, Mitsuru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minoguchi, Kenji</au><au>Yokoe, Takuya</au><au>Tazaki, Toshiyuki</au><au>Minoguchi, Hideko</au><au>Tanaka, Akihiko</au><au>Oda, Naruhito</au><au>Okada, Shinji</au><au>Ohta, Shin</au><au>Naito, Hirokuni</au><au>Adachi, Mitsuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>172</volume><issue>5</issue><spage>625</spage><epage>630</epage><pages>625-630</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Increased carotid intima-media thickness (IMT) and increased serum levels of inflammatory markers, such as C-reactive protein (CRP), interleukin (IL)-6, and IL-18, are associated with an increased risk of cardiovascular and cerebrovascular diseases. The aim of this study was to evaluate whether carotid IMT, a useful marker for early atherosclerosis, is associated with these inflammatory markers in patients with obstructive sleep apnea (OSA). Carotid IMT was investigated with ultrasonography in 36 patients with OSA and 16 obese control subjects. Serum levels of CRP, IL-6, and IL-18 were measured at 5:00 A.M. Carotid IMT (p < 0.001) and serum levels of CRP (p < 0.003), IL-6 (p < 0.005), and IL-18 (p < 0.03) of patients with OSA were significantly higher than those of obese control subjects. Carotid IMT was significantly correlated with serum levels of CRP (r = 0.61, p = 0.0001), IL-6 (r = 0.41, p = 0.01), and IL-18 (r = 0.45, p = 0.005), duration of OSA-related hypoxia (r = 0.60, p = 0.0001), and severity of OSA (r = 0.50, p = 0.002). In addition, the primary factor influencing carotid IMT was duration of hypoxia during total sleep time (p = 0.036). These results suggest that OSA-related hypoxia and systemic inflammation might be associated with the progression of atherosclerosis and thus might increase the risks of cardiovascular and cerebrovascular morbidity in patients with OSA.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>16120716</pmid><doi>10.1164/rccm.200412-1652OC</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2005-09, Vol.172 (5), p.625-630 |
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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - blood Body Weights and Measures C-Reactive Protein - analysis Carotid Arteries - diagnostic imaging Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - immunology Chronic obstructive pulmonary disease, asthma Emergency and intensive care: infection, septic shock Humans Intensive care medicine Interleukin-18 - blood Interleukin-6 - blood Male Medical sciences Middle Aged Obesity - blood Obesity - complications Obesity - immunology Pneumology Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - immunology Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography |
| title | Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea |
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