Scintigraphic Evaluation of TPLO and CTWO in Canine Osteoarthritis
The objective of this study was to evaluate the bone uptake of the bone-seeking radionuclide 99m technetium-methylene diphosphonate ( 99m Tc-MDP) in order to examine and compare the clinical efficacies of tibial plateau leveling osteotomy (TPLO) and cranial tibial wedge osteotomy (CTWO) for the corr...
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| Veröffentlicht in: | In vivo (Athens) 2007-09, Vol.21 (5), p.855-859 |
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| container_title | In vivo (Athens) |
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| creator | Lee, Jae Yeong Kim, Joong-Hyun Lee, Won-Guk Han, Tae Sung Cho, Kirae Han, Hyun-Jung Kang, Seong Soo Kim, Gonhyung Choi, Seok Hwa |
| description | The objective of this study was to evaluate the bone uptake of the bone-seeking radionuclide 99m technetium-methylene diphosphonate ( 99m Tc-MDP) in order to examine and compare the clinical efficacies of tibial plateau leveling osteotomy (TPLO) and cranial tibial
wedge osteotomy (CTWO) for the correction of experimentally induced cranial cruciate ligament (CrCL) transected stifle. Fifteen
healthy adult beagle dogs, weighing between 10 and 15 kg, were used for this study. Dogs were assigned to TPLO (n=5), CTWO
(n=5) or a control sham group (n=5) and screened with both physical and complete orthopedic examinations. Left CrCLs were
transected and two of the three groups were stabilized using TPLO and CTWO. Scintigraphic evaluation of the stifle was performed
before TPLO or CTWO surgical repair of the left limb and again at 4, 8 and 12 weeks after surgery. Bone uptake values at 8
and 12 weeks for the TPLO and CTWO groups were not significantly different from their preoperative values, but these differed
significantly from the control group at 4, 8 and 12 weeks (p |
| format | Article |
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wedge osteotomy (CTWO) for the correction of experimentally induced cranial cruciate ligament (CrCL) transected stifle. Fifteen
healthy adult beagle dogs, weighing between 10 and 15 kg, were used for this study. Dogs were assigned to TPLO (n=5), CTWO
(n=5) or a control sham group (n=5) and screened with both physical and complete orthopedic examinations. Left CrCLs were
transected and two of the three groups were stabilized using TPLO and CTWO. Scintigraphic evaluation of the stifle was performed
before TPLO or CTWO surgical repair of the left limb and again at 4, 8 and 12 weeks after surgery. Bone uptake values at 8
and 12 weeks for the TPLO and CTWO groups were not significantly different from their preoperative values, but these differed
significantly from the control group at 4, 8 and 12 weeks (p<0.01). No significant differences were found between TPLO and
CTWO values. In summary, the relative efficacy of CTWO approximately equals that of TPLO. Moreover, the results of this study
confirmed that TPLO and CTWO inhibited the progression of osteoarthritis in CrCL-deficient dogs.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 18019424</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Animals ; Dog Diseases - diagnostic imaging ; Dogs ; Osteoarthritis - diagnostic imaging ; Osteoarthritis - veterinary ; Osteotomy - veterinary ; Radionuclide Imaging</subject><ispartof>In vivo (Athens), 2007-09, Vol.21 (5), p.855-859</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18019424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jae Yeong</creatorcontrib><creatorcontrib>Kim, Joong-Hyun</creatorcontrib><creatorcontrib>Lee, Won-Guk</creatorcontrib><creatorcontrib>Han, Tae Sung</creatorcontrib><creatorcontrib>Cho, Kirae</creatorcontrib><creatorcontrib>Han, Hyun-Jung</creatorcontrib><creatorcontrib>Kang, Seong Soo</creatorcontrib><creatorcontrib>Kim, Gonhyung</creatorcontrib><creatorcontrib>Choi, Seok Hwa</creatorcontrib><title>Scintigraphic Evaluation of TPLO and CTWO in Canine Osteoarthritis</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>The objective of this study was to evaluate the bone uptake of the bone-seeking radionuclide 99m technetium-methylene diphosphonate ( 99m Tc-MDP) in order to examine and compare the clinical efficacies of tibial plateau leveling osteotomy (TPLO) and cranial tibial
wedge osteotomy (CTWO) for the correction of experimentally induced cranial cruciate ligament (CrCL) transected stifle. Fifteen
healthy adult beagle dogs, weighing between 10 and 15 kg, were used for this study. Dogs were assigned to TPLO (n=5), CTWO
(n=5) or a control sham group (n=5) and screened with both physical and complete orthopedic examinations. Left CrCLs were
transected and two of the three groups were stabilized using TPLO and CTWO. Scintigraphic evaluation of the stifle was performed
before TPLO or CTWO surgical repair of the left limb and again at 4, 8 and 12 weeks after surgery. Bone uptake values at 8
and 12 weeks for the TPLO and CTWO groups were not significantly different from their preoperative values, but these differed
significantly from the control group at 4, 8 and 12 weeks (p<0.01). No significant differences were found between TPLO and
CTWO values. In summary, the relative efficacy of CTWO approximately equals that of TPLO. Moreover, the results of this study
confirmed that TPLO and CTWO inhibited the progression of osteoarthritis in CrCL-deficient dogs.</description><subject>Animals</subject><subject>Dog Diseases - diagnostic imaging</subject><subject>Dogs</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Osteoarthritis - veterinary</subject><subject>Osteotomy - veterinary</subject><subject>Radionuclide Imaging</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1z0tLxDAUBeAgijOO_gXJQtwVkqZp0qUWXzBQwRHdhds0mUb6GJt0xH9vYMbVgcPH5Z4TtKSioIngWXGKliTlMpGcfi7QhfdfhOSCkPQcLagktMjSbInu37QbgttOsGudxg976GYIbhzwaPHmdV1hGBpcbj4q7AZcwuAGgysfzAhTaCcXnL9EZxY6b66OuULvjw-b8jlZV08v5d06aVMmQ5LrWmRgGaOC1FKS-GItRcFqaxsLrAZoIKMm4xmXGmKZ2lxEILQ1DWjCVuj2cHc3jd-z8UH1zmvTdTCYcfYqj0tZLmmE10c4171p1G5yPUy_6n91BDcH0Lpt--Mmo3wPXRc5U26fUsWV5Jz9AR30YQk</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Lee, Jae Yeong</creator><creator>Kim, Joong-Hyun</creator><creator>Lee, Won-Guk</creator><creator>Han, Tae Sung</creator><creator>Cho, Kirae</creator><creator>Han, Hyun-Jung</creator><creator>Kang, Seong Soo</creator><creator>Kim, Gonhyung</creator><creator>Choi, Seok Hwa</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Scintigraphic Evaluation of TPLO and CTWO in Canine Osteoarthritis</title><author>Lee, Jae Yeong ; Kim, Joong-Hyun ; Lee, Won-Guk ; Han, Tae Sung ; Cho, Kirae ; Han, Hyun-Jung ; Kang, Seong Soo ; Kim, Gonhyung ; Choi, Seok Hwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-6cb74af33170b880549b8793bffdfa3baada41e45458caffd2f678797cfedac03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Dog Diseases - diagnostic imaging</topic><topic>Dogs</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Osteoarthritis - veterinary</topic><topic>Osteotomy - veterinary</topic><topic>Radionuclide Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jae Yeong</creatorcontrib><creatorcontrib>Kim, Joong-Hyun</creatorcontrib><creatorcontrib>Lee, Won-Guk</creatorcontrib><creatorcontrib>Han, Tae Sung</creatorcontrib><creatorcontrib>Cho, Kirae</creatorcontrib><creatorcontrib>Han, Hyun-Jung</creatorcontrib><creatorcontrib>Kang, Seong Soo</creatorcontrib><creatorcontrib>Kim, Gonhyung</creatorcontrib><creatorcontrib>Choi, Seok Hwa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jae Yeong</au><au>Kim, Joong-Hyun</au><au>Lee, Won-Guk</au><au>Han, Tae Sung</au><au>Cho, Kirae</au><au>Han, Hyun-Jung</au><au>Kang, Seong Soo</au><au>Kim, Gonhyung</au><au>Choi, Seok Hwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scintigraphic Evaluation of TPLO and CTWO in Canine Osteoarthritis</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>21</volume><issue>5</issue><spage>855</spage><epage>859</epage><pages>855-859</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>The objective of this study was to evaluate the bone uptake of the bone-seeking radionuclide 99m technetium-methylene diphosphonate ( 99m Tc-MDP) in order to examine and compare the clinical efficacies of tibial plateau leveling osteotomy (TPLO) and cranial tibial
wedge osteotomy (CTWO) for the correction of experimentally induced cranial cruciate ligament (CrCL) transected stifle. Fifteen
healthy adult beagle dogs, weighing between 10 and 15 kg, were used for this study. Dogs were assigned to TPLO (n=5), CTWO
(n=5) or a control sham group (n=5) and screened with both physical and complete orthopedic examinations. Left CrCLs were
transected and two of the three groups were stabilized using TPLO and CTWO. Scintigraphic evaluation of the stifle was performed
before TPLO or CTWO surgical repair of the left limb and again at 4, 8 and 12 weeks after surgery. Bone uptake values at 8
and 12 weeks for the TPLO and CTWO groups were not significantly different from their preoperative values, but these differed
significantly from the control group at 4, 8 and 12 weeks (p<0.01). No significant differences were found between TPLO and
CTWO values. In summary, the relative efficacy of CTWO approximately equals that of TPLO. Moreover, the results of this study
confirmed that TPLO and CTWO inhibited the progression of osteoarthritis in CrCL-deficient dogs.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>18019424</pmid><tpages>5</tpages></addata></record> |
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| issn | 0258-851X 1791-7549 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Dog Diseases - diagnostic imaging Dogs Osteoarthritis - diagnostic imaging Osteoarthritis - veterinary Osteotomy - veterinary Radionuclide Imaging |
| title | Scintigraphic Evaluation of TPLO and CTWO in Canine Osteoarthritis |
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