The impact of skin disease following renal transplantation on quality of life
Summary Background The immunosuppressive therapy a patient requires to sustain a functioning renal allograft in the long term is associated with various skin complications. While quality of life (QoL) after renal transplantation has been studied, no publications document the effect of post‐transpla...
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| Veröffentlicht in: | British journal of dermatology (1951) 2005-09, Vol.153 (3), p.574-578 |
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| creator | Moloney, F.J. Keane, S. O'Kelly, P. Conlon, P.J. Murphy, G.M. |
| description | Summary
Background The immunosuppressive therapy a patient requires to sustain a functioning renal allograft in the long term is associated with various skin complications. While quality of life (QoL) after renal transplantation has been studied, no publications document the effect of post‐transplant dermatological complications on QoL.
Objectives The objective of the study was to document the prevalence of the skin diseases that commonly occur in association with post‐transplant immunosuppression. A general dermatological quality of life questionnaire, the Dermatology Life Quality Index (DLQI), was used to assess the QoL effect of these cutaneous complications. The study was designed to examine further the impact of age, sex, duration since transplant and immunosuppressive regimen on the DLQI score of renal transplant recipients (RTR).
Methods One hundred and seventy‐three RTR completed the DLQI, were interviewed and examined for evidence of common post‐transplant skin diseases.
Results Sixteen per cent of RTR had DLQI scores >6, reflecting a significant impact on their QoL. Dry skin, itch, hypertrichosis, sebaceous gland hyperplasia, acne, genital warts and a history of >4 herpes simplex virus type 1 infections in the past year were all found to have a significant impact on the quality of life (P |
| doi_str_mv | 10.1111/j.1365-2133.2005.06699.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68512991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68512991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4799-620940852601787574507e023af22c5d79d453951d8c2fd900ed4ad98999dda23</originalsourceid><addsrcrecordid>eNpdkV1PHCEUhklTU1ftXzCkib2b8QADDBe9sOr6Eb8ubNo7ggPTsrIz6zATd_-9jLtqUkICyXneA-d9EcIEcpLW4SwnTPCMEsZyCsBzEEKpfPkJTd4Ln9EEAGQGSrBttBPjDIAw4PAFbRNBKJCCT9D1_T-H_Xxhqh63NY6PvsHWR2eiw3UbQvvsm7-4c40JuO9MExfBNL3pfdvgtJ8GE3y_GqXB124PbdUmRPd1c-6iX9PT--Pz7Or27OL46CqrCqlUJiioAkpOBRBZSi4LDtIBZaamtOJWKltwpjixZUVrqwCcLYxVpVLKWkPZLvq-7rvo2qfBxV7PfaxcSH9z7RC1KDmhSpEEfvsPnLVDl4aJOvlGKBG8TND-Bhoe5s7qRefnplvpN5cScLABTKxMqJMPlY8fnIQ0AVeJ-7Hmnn1wq4866DE1PdNjOHoMZ3yd69fU9FL_vDwZb0mfrfU-9m75rjfdoxaSSa5_35zp6R9C7oopaGAvLaGWpg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>200121658</pqid></control><display><type>article</type><title>The impact of skin disease following renal transplantation on quality of life</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Moloney, F.J. ; Keane, S. ; O'Kelly, P. ; Conlon, P.J. ; Murphy, G.M.</creator><creatorcontrib>Moloney, F.J. ; Keane, S. ; O'Kelly, P. ; Conlon, P.J. ; Murphy, G.M.</creatorcontrib><description>Summary
Background The immunosuppressive therapy a patient requires to sustain a functioning renal allograft in the long term is associated with various skin complications. While quality of life (QoL) after renal transplantation has been studied, no publications document the effect of post‐transplant dermatological complications on QoL.
Objectives The objective of the study was to document the prevalence of the skin diseases that commonly occur in association with post‐transplant immunosuppression. A general dermatological quality of life questionnaire, the Dermatology Life Quality Index (DLQI), was used to assess the QoL effect of these cutaneous complications. The study was designed to examine further the impact of age, sex, duration since transplant and immunosuppressive regimen on the DLQI score of renal transplant recipients (RTR).
Methods One hundred and seventy‐three RTR completed the DLQI, were interviewed and examined for evidence of common post‐transplant skin diseases.
Results Sixteen per cent of RTR had DLQI scores >6, reflecting a significant impact on their QoL. Dry skin, itch, hypertrichosis, sebaceous gland hyperplasia, acne, genital warts and a history of >4 herpes simplex virus type 1 infections in the past year were all found to have a significant impact on the quality of life (P < 0·05). Multivariate analysis revealed that the greatest impact on QoL was in RTR who were younger, female and with multiple skin problems (P < 0·05).
Conclusions The dermatological complications of immunosuppressive therapy are common in RTR and can significantly impair QoL in certain individuals. Visible, infectious and cosmetic skin problems had most impact on QoL while a history of skin cancer had a lesser impact. Early dermatological referral and careful choice of immunosuppression may enhance the QoL, particularly in young and female RTR.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2005.06699.x</identifier><identifier>PMID: 16120145</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>acne ; Adult ; Age Factors ; Biological and medical sciences ; Dermatology ; Female ; genital warts ; Hair and nails disorders ; Herpes Simplex - complications ; Herpesvirus 1, Human ; Humans ; hypertrichosis ; Immunosuppressive Agents - adverse effects ; Kidney Failure, Chronic - immunology ; Kidney Failure, Chronic - psychology ; Kidney Failure, Chronic - surgery ; Kidney Transplantation - adverse effects ; Kidney Transplantation - psychology ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Prevalence ; pruritus ; Quality of Life ; recurrent HSV infections ; sebaceous gland hyperplasia ; Sex Factors ; Skin Diseases - complications ; Skin Diseases - etiology ; Skin Diseases - psychology ; Skin Neoplasms - complications ; Skin Neoplasms - etiology ; Skin Neoplasms - psychology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Surveys and Questionnaires ; Time Factors</subject><ispartof>British journal of dermatology (1951), 2005-09, Vol.153 (3), p.574-578</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Sep 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4799-620940852601787574507e023af22c5d79d453951d8c2fd900ed4ad98999dda23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2005.06699.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2005.06699.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17074559$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16120145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moloney, F.J.</creatorcontrib><creatorcontrib>Keane, S.</creatorcontrib><creatorcontrib>O'Kelly, P.</creatorcontrib><creatorcontrib>Conlon, P.J.</creatorcontrib><creatorcontrib>Murphy, G.M.</creatorcontrib><title>The impact of skin disease following renal transplantation on quality of life</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background The immunosuppressive therapy a patient requires to sustain a functioning renal allograft in the long term is associated with various skin complications. While quality of life (QoL) after renal transplantation has been studied, no publications document the effect of post‐transplant dermatological complications on QoL.
Objectives The objective of the study was to document the prevalence of the skin diseases that commonly occur in association with post‐transplant immunosuppression. A general dermatological quality of life questionnaire, the Dermatology Life Quality Index (DLQI), was used to assess the QoL effect of these cutaneous complications. The study was designed to examine further the impact of age, sex, duration since transplant and immunosuppressive regimen on the DLQI score of renal transplant recipients (RTR).
Methods One hundred and seventy‐three RTR completed the DLQI, were interviewed and examined for evidence of common post‐transplant skin diseases.
Results Sixteen per cent of RTR had DLQI scores >6, reflecting a significant impact on their QoL. Dry skin, itch, hypertrichosis, sebaceous gland hyperplasia, acne, genital warts and a history of >4 herpes simplex virus type 1 infections in the past year were all found to have a significant impact on the quality of life (P < 0·05). Multivariate analysis revealed that the greatest impact on QoL was in RTR who were younger, female and with multiple skin problems (P < 0·05).
Conclusions The dermatological complications of immunosuppressive therapy are common in RTR and can significantly impair QoL in certain individuals. Visible, infectious and cosmetic skin problems had most impact on QoL while a history of skin cancer had a lesser impact. Early dermatological referral and careful choice of immunosuppression may enhance the QoL, particularly in young and female RTR.</description><subject>acne</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Female</subject><subject>genital warts</subject><subject>Hair and nails disorders</subject><subject>Herpes Simplex - complications</subject><subject>Herpesvirus 1, Human</subject><subject>Humans</subject><subject>hypertrichosis</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Kidney Failure, Chronic - immunology</subject><subject>Kidney Failure, Chronic - psychology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prevalence</subject><subject>pruritus</subject><subject>Quality of Life</subject><subject>recurrent HSV infections</subject><subject>sebaceous gland hyperplasia</subject><subject>Sex Factors</subject><subject>Skin Diseases - complications</subject><subject>Skin Diseases - etiology</subject><subject>Skin Diseases - psychology</subject><subject>Skin Neoplasms - complications</subject><subject>Skin Neoplasms - etiology</subject><subject>Skin Neoplasms - psychology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1PHCEUhklTU1ftXzCkib2b8QADDBe9sOr6Eb8ubNo7ggPTsrIz6zATd_-9jLtqUkICyXneA-d9EcIEcpLW4SwnTPCMEsZyCsBzEEKpfPkJTd4Ln9EEAGQGSrBttBPjDIAw4PAFbRNBKJCCT9D1_T-H_Xxhqh63NY6PvsHWR2eiw3UbQvvsm7-4c40JuO9MExfBNL3pfdvgtJ8GE3y_GqXB124PbdUmRPd1c-6iX9PT--Pz7Or27OL46CqrCqlUJiioAkpOBRBZSi4LDtIBZaamtOJWKltwpjixZUVrqwCcLYxVpVLKWkPZLvq-7rvo2qfBxV7PfaxcSH9z7RC1KDmhSpEEfvsPnLVDl4aJOvlGKBG8TND-Bhoe5s7qRefnplvpN5cScLABTKxMqJMPlY8fnIQ0AVeJ-7Hmnn1wq4866DE1PdNjOHoMZ3yd69fU9FL_vDwZb0mfrfU-9m75rjfdoxaSSa5_35zp6R9C7oopaGAvLaGWpg</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Moloney, F.J.</creator><creator>Keane, S.</creator><creator>O'Kelly, P.</creator><creator>Conlon, P.J.</creator><creator>Murphy, G.M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>The impact of skin disease following renal transplantation on quality of life</title><author>Moloney, F.J. ; Keane, S. ; O'Kelly, P. ; Conlon, P.J. ; Murphy, G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4799-620940852601787574507e023af22c5d79d453951d8c2fd900ed4ad98999dda23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acne</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Female</topic><topic>genital warts</topic><topic>Hair and nails disorders</topic><topic>Herpes Simplex - complications</topic><topic>Herpesvirus 1, Human</topic><topic>Humans</topic><topic>hypertrichosis</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Kidney Failure, Chronic - immunology</topic><topic>Kidney Failure, Chronic - psychology</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prevalence</topic><topic>pruritus</topic><topic>Quality of Life</topic><topic>recurrent HSV infections</topic><topic>sebaceous gland hyperplasia</topic><topic>Sex Factors</topic><topic>Skin Diseases - complications</topic><topic>Skin Diseases - etiology</topic><topic>Skin Diseases - psychology</topic><topic>Skin Neoplasms - complications</topic><topic>Skin Neoplasms - etiology</topic><topic>Skin Neoplasms - psychology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moloney, F.J.</creatorcontrib><creatorcontrib>Keane, S.</creatorcontrib><creatorcontrib>O'Kelly, P.</creatorcontrib><creatorcontrib>Conlon, P.J.</creatorcontrib><creatorcontrib>Murphy, G.M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moloney, F.J.</au><au>Keane, S.</au><au>O'Kelly, P.</au><au>Conlon, P.J.</au><au>Murphy, G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of skin disease following renal transplantation on quality of life</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2005-09</date><risdate>2005</risdate><volume>153</volume><issue>3</issue><spage>574</spage><epage>578</epage><pages>574-578</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background The immunosuppressive therapy a patient requires to sustain a functioning renal allograft in the long term is associated with various skin complications. While quality of life (QoL) after renal transplantation has been studied, no publications document the effect of post‐transplant dermatological complications on QoL.
Objectives The objective of the study was to document the prevalence of the skin diseases that commonly occur in association with post‐transplant immunosuppression. A general dermatological quality of life questionnaire, the Dermatology Life Quality Index (DLQI), was used to assess the QoL effect of these cutaneous complications. The study was designed to examine further the impact of age, sex, duration since transplant and immunosuppressive regimen on the DLQI score of renal transplant recipients (RTR).
Methods One hundred and seventy‐three RTR completed the DLQI, were interviewed and examined for evidence of common post‐transplant skin diseases.
Results Sixteen per cent of RTR had DLQI scores >6, reflecting a significant impact on their QoL. Dry skin, itch, hypertrichosis, sebaceous gland hyperplasia, acne, genital warts and a history of >4 herpes simplex virus type 1 infections in the past year were all found to have a significant impact on the quality of life (P < 0·05). Multivariate analysis revealed that the greatest impact on QoL was in RTR who were younger, female and with multiple skin problems (P < 0·05).
Conclusions The dermatological complications of immunosuppressive therapy are common in RTR and can significantly impair QoL in certain individuals. Visible, infectious and cosmetic skin problems had most impact on QoL while a history of skin cancer had a lesser impact. Early dermatological referral and careful choice of immunosuppression may enhance the QoL, particularly in young and female RTR.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16120145</pmid><doi>10.1111/j.1365-2133.2005.06699.x</doi><tpages>5</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acne Adult Age Factors Biological and medical sciences Dermatology Female genital warts Hair and nails disorders Herpes Simplex - complications Herpesvirus 1, Human Humans hypertrichosis Immunosuppressive Agents - adverse effects Kidney Failure, Chronic - immunology Kidney Failure, Chronic - psychology Kidney Failure, Chronic - surgery Kidney Transplantation - adverse effects Kidney Transplantation - psychology Male Medical sciences Middle Aged Multivariate Analysis Prevalence pruritus Quality of Life recurrent HSV infections sebaceous gland hyperplasia Sex Factors Skin Diseases - complications Skin Diseases - etiology Skin Diseases - psychology Skin Neoplasms - complications Skin Neoplasms - etiology Skin Neoplasms - psychology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Surveys and Questionnaires Time Factors |
| title | The impact of skin disease following renal transplantation on quality of life |
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