A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions

Summary Background We previously demonstrated that low concentrations of a new antihistamine levocetirizine inhibited eosinophil transmigration through human microvascular endothelial cells. Objective Here, the inhibitory effect of levocetirizine on eosinophil adhesion to recombinant human vascular...

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Veröffentlicht in:	Clinical and experimental allergy 2005-08, Vol.35 (8), p.1073-1079
Hauptverfasser:	Wu, P., Mitchell, S., Walsh, G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Allergic diseases Antibodies, Monoclonal - immunology antihistamines Biological and medical sciences Cell Adhesion - immunology Cetirizine - immunology Dose-Response Relationship, Immunologic eosinophils Eosinophils - immunology flow conditions Fundamental and applied biological sciences. Psychology Fundamental immunology Granulocyte-Macrophage Colony-Stimulating Factor - immunology Histamine H1 Antagonists, Non-Sedating - immunology Humans Immunopathology Integrin alpha4beta1 - analysis Integrin alpha4beta1 - immunology levocetirizine Medical sciences Microscopy, Confocal - methods Models, Biological Piperazines - immunology Recombinant Proteins - immunology Regional Blood Flow - immunology Vascular Cell Adhesion Molecule-1 - immunology VCAM-1 VLA-4
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