SIRT1 transgenic mice show phenotypes resembling calorie restriction
Summary We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice dis...
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| Veröffentlicht in: | Aging cell 2007-12, Vol.6 (6), p.759-767 |
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| creator | Bordone, Laura Cohen, Dena Robinson, Ashley Motta, Maria Carla Van Veen, Ed Czopik, Agnieszka Steele, Andrew D. Crowe, Hayley Marmor, Stephen Luo, Jianyuan Gu, Wei Guarente, Leonard |
| description | Summary
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. |
| doi_str_mv | 10.1111/j.1474-9726.2007.00335.x |
| format | Article |
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We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/j.1474-9726.2007.00335.x</identifier><identifier>PMID: 17877786</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adipokines - blood ; Animals ; Blood Glucose - analysis ; Caloric Restriction ; calorie restriction ; Cholesterol - blood ; Insulin - blood ; Longevity - genetics ; Mice ; Mice, Transgenic ; Phenotype ; SIRT1 ; Sirtuin 1 ; Sirtuins - genetics ; Sirtuins - metabolism ; transgenic mice ; Up-Regulation</subject><ispartof>Aging cell, 2007-12, Vol.6 (6), p.759-767</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5695-602c93d9f44829dc151dedc0bf3c226208f6a2e749ad9a158570d75579bc2e673</citedby><cites>FETCH-LOGICAL-c5695-602c93d9f44829dc151dedc0bf3c226208f6a2e749ad9a158570d75579bc2e673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1474-9726.2007.00335.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1474-9726.2007.00335.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1474-9726.2007.00335.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17877786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bordone, Laura</creatorcontrib><creatorcontrib>Cohen, Dena</creatorcontrib><creatorcontrib>Robinson, Ashley</creatorcontrib><creatorcontrib>Motta, Maria Carla</creatorcontrib><creatorcontrib>Van Veen, Ed</creatorcontrib><creatorcontrib>Czopik, Agnieszka</creatorcontrib><creatorcontrib>Steele, Andrew D.</creatorcontrib><creatorcontrib>Crowe, Hayley</creatorcontrib><creatorcontrib>Marmor, Stephen</creatorcontrib><creatorcontrib>Luo, Jianyuan</creatorcontrib><creatorcontrib>Gu, Wei</creatorcontrib><creatorcontrib>Guarente, Leonard</creatorcontrib><title>SIRT1 transgenic mice show phenotypes resembling calorie restriction</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Summary
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.</description><subject>Adipokines - blood</subject><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Caloric Restriction</subject><subject>calorie restriction</subject><subject>Cholesterol - blood</subject><subject>Insulin - blood</subject><subject>Longevity - genetics</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Phenotype</subject><subject>SIRT1</subject><subject>Sirtuin 1</subject><subject>Sirtuins - genetics</subject><subject>Sirtuins - metabolism</subject><subject>transgenic mice</subject><subject>Up-Regulation</subject><issn>1474-9718</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EolD4BZQVuwTbiV8LFlUpUKkSEpS1lTiT1lUexU7V9u9JaFWWMJsZ2WfuSAehgOCIdPWwikgiklAJyiOKsYgwjmMW7c7Q1enj_DQTOUDX3q8wJkLh-BINiJBCCMmv0NPH9H1OgtaltV9AbU1QWQOBXzbbYL2Eumn3a_CBAw9VVtp6EZi0bJyF_ql11rS2qW_QRZGWHm6PfYg-nyfz8Ws4e3uZjkez0DCuWMgxNSrOVZEkkqrcEEZyyA3OithQyimWBU8piESluUoJk0zgXDAmVGYocBEP0f0hd-2ar013X1fWGyjLtIZm4zWXjHQpf4NESaWwUh0oD6BxjfcOCr12tkrdXhOse9V6pXuLujeqe9X6R7Xedat3xxubrIL8d_HotgMeD8DWlrD_d7AejSezboq_AeJvjH0</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Bordone, Laura</creator><creator>Cohen, Dena</creator><creator>Robinson, Ashley</creator><creator>Motta, Maria Carla</creator><creator>Van Veen, Ed</creator><creator>Czopik, Agnieszka</creator><creator>Steele, Andrew D.</creator><creator>Crowe, Hayley</creator><creator>Marmor, Stephen</creator><creator>Luo, Jianyuan</creator><creator>Gu, Wei</creator><creator>Guarente, Leonard</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>SIRT1 transgenic mice show phenotypes resembling calorie restriction</title><author>Bordone, Laura ; Cohen, Dena ; Robinson, Ashley ; Motta, Maria Carla ; Van Veen, Ed ; Czopik, Agnieszka ; Steele, Andrew D. ; Crowe, Hayley ; Marmor, Stephen ; Luo, Jianyuan ; Gu, Wei ; Guarente, Leonard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5695-602c93d9f44829dc151dedc0bf3c226208f6a2e749ad9a158570d75579bc2e673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adipokines - blood</topic><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Caloric Restriction</topic><topic>calorie restriction</topic><topic>Cholesterol - blood</topic><topic>Insulin - blood</topic><topic>Longevity - genetics</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Phenotype</topic><topic>SIRT1</topic><topic>Sirtuin 1</topic><topic>Sirtuins - genetics</topic><topic>Sirtuins - metabolism</topic><topic>transgenic mice</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bordone, Laura</creatorcontrib><creatorcontrib>Cohen, Dena</creatorcontrib><creatorcontrib>Robinson, Ashley</creatorcontrib><creatorcontrib>Motta, Maria Carla</creatorcontrib><creatorcontrib>Van Veen, Ed</creatorcontrib><creatorcontrib>Czopik, Agnieszka</creatorcontrib><creatorcontrib>Steele, Andrew D.</creatorcontrib><creatorcontrib>Crowe, Hayley</creatorcontrib><creatorcontrib>Marmor, Stephen</creatorcontrib><creatorcontrib>Luo, Jianyuan</creatorcontrib><creatorcontrib>Gu, Wei</creatorcontrib><creatorcontrib>Guarente, Leonard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Bordone, Laura</au><au>Cohen, Dena</au><au>Robinson, Ashley</au><au>Motta, Maria Carla</au><au>Van Veen, Ed</au><au>Czopik, Agnieszka</au><au>Steele, Andrew D.</au><au>Crowe, Hayley</au><au>Marmor, Stephen</au><au>Luo, Jianyuan</au><au>Gu, Wei</au><au>Guarente, Leonard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SIRT1 transgenic mice show phenotypes resembling calorie restriction</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2007-12</date><risdate>2007</risdate><volume>6</volume><issue>6</issue><spage>759</spage><epage>767</epage><pages>759-767</pages><issn>1474-9718</issn><eissn>1474-9726</eissn><abstract>Summary
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17877786</pmid><doi>10.1111/j.1474-9726.2007.00335.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipokines - blood Animals Blood Glucose - analysis Caloric Restriction calorie restriction Cholesterol - blood Insulin - blood Longevity - genetics Mice Mice, Transgenic Phenotype SIRT1 Sirtuin 1 Sirtuins - genetics Sirtuins - metabolism transgenic mice Up-Regulation |
| title | SIRT1 transgenic mice show phenotypes resembling calorie restriction |
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