DNA Repair Single-Nucleotide Polymorphisms in Colorectal Cancer and their Role as Modifiers of the Effect of Cigarette Smoking and Alcohol in the Singapore Chinese Health Study
Recently, we reported that among Singapore Chinese, cigarette smoking and alcohol drinking were independent risk factors for colorectal cancer. Both tobacco smoking and alcohol use are plausible colorectal cancer risk factors, partly due to their ability to induce mutations in the colorectal lumen....
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-11, Vol.16 (11), p.2363-2372 |
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| creator | STERN, Mariana C CONTI, David V SIEGMUND, Kimberly D CORRAL, Roman YUAN, Jian-Min KOH, Woon-Puay YU, Mimi C |
| description | Recently, we reported that among Singapore Chinese, cigarette smoking and alcohol drinking were independent risk factors for
colorectal cancer. Both tobacco smoking and alcohol use are plausible colorectal cancer risk factors, partly due to their
ability to induce mutations in the colorectal lumen. In the present study, we investigated the role in colorectal cancer of
single-nucleotide polymorphisms in five DNA repair genes: XRCC1 (Arg 194 Trp and Arg 399 Gln), PARP (Val 762 Ala, Lys 940 Arg), XPD (Asp 312 Asn, Lys 751 Gln), OGG1 (Ser 326 Cys), and MGMT (Leu 84 Phe). We conducted this study within the Singapore Chinese Health Study, a population-based cohort of 63,257 middle-aged and
older Singapore Chinese men and women enrolled between 1993 and 1998. Our study included 1,176 controls and 310 cases (180
colon and 130 rectum cancer). We observed a positive association between the PARP codon 940 Lys/Arg and Arg/Arg genotypes and colorectal cancer risk [odds ratio (OR), 1.8; 95% confidence interval (95% CI),
1.1-3.1], and an inverse association between the MGMT codon 84 Leu/Phe or Phe/Phe genotypes and colon cancer risk (OR, 0.6; 95% CI, 0.3-0.9), but not rectal cancer (test of heterogeneity
by tumor site, P = 0.027). We observed evidence that XRCC1 may modify the effects of smoking (interaction P = 0.012). The effect of smoking among carriers of the Arg 194 -Gln 399 haplotype was OR = 0.7 (95% CI, 0.4-1.1), whereas, among carriers of the Trp 194 -Arg 399 haplotype, it was OR = 1.6 (95% CI, 1.1-2.5). We also observed a nonstatistically significant modification of XRCC1 on the effects of alcohol ( P = 0.245). Whereas alcohol had no effect among carriers of the codon 194 Arg/Arg (OR, 1.0; 95% CI, 0.6-1.7) or Arg/Trp genotypes
(OR, 1.1; 95% CI, 0.6-1.9), there was a positive association among carriers of the Trp/Trp genotype (OR, 2.8; 95% CI, 1.0-8.1).
Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking
and alcohol on colorectal cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2363–72) |
| doi_str_mv | 10.1158/1055-9965.EPI-07-0268 |
| format | Article |
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colorectal cancer. Both tobacco smoking and alcohol use are plausible colorectal cancer risk factors, partly due to their
ability to induce mutations in the colorectal lumen. In the present study, we investigated the role in colorectal cancer of
single-nucleotide polymorphisms in five DNA repair genes: XRCC1 (Arg 194 Trp and Arg 399 Gln), PARP (Val 762 Ala, Lys 940 Arg), XPD (Asp 312 Asn, Lys 751 Gln), OGG1 (Ser 326 Cys), and MGMT (Leu 84 Phe). We conducted this study within the Singapore Chinese Health Study, a population-based cohort of 63,257 middle-aged and
older Singapore Chinese men and women enrolled between 1993 and 1998. Our study included 1,176 controls and 310 cases (180
colon and 130 rectum cancer). We observed a positive association between the PARP codon 940 Lys/Arg and Arg/Arg genotypes and colorectal cancer risk [odds ratio (OR), 1.8; 95% confidence interval (95% CI),
1.1-3.1], and an inverse association between the MGMT codon 84 Leu/Phe or Phe/Phe genotypes and colon cancer risk (OR, 0.6; 95% CI, 0.3-0.9), but not rectal cancer (test of heterogeneity
by tumor site, P = 0.027). We observed evidence that XRCC1 may modify the effects of smoking (interaction P = 0.012). The effect of smoking among carriers of the Arg 194 -Gln 399 haplotype was OR = 0.7 (95% CI, 0.4-1.1), whereas, among carriers of the Trp 194 -Arg 399 haplotype, it was OR = 1.6 (95% CI, 1.1-2.5). We also observed a nonstatistically significant modification of XRCC1 on the effects of alcohol ( P = 0.245). Whereas alcohol had no effect among carriers of the codon 194 Arg/Arg (OR, 1.0; 95% CI, 0.6-1.7) or Arg/Trp genotypes
(OR, 1.1; 95% CI, 0.6-1.9), there was a positive association among carriers of the Trp/Trp genotype (OR, 2.8; 95% CI, 1.0-8.1).
Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking
and alcohol on colorectal cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2363–72)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-07-0268</identifier><identifier>PMID: 18006925</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Aged ; Alcohol Drinking - genetics ; Alcohol Drinking - metabolism ; Biological and medical sciences ; Case-Control Studies ; Cohort Studies ; Colorectal ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; DNA Repair ; DNA-Binding Proteins - genetics ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotype ; Humans ; Male ; Medical sciences ; Middle Aged ; PARP ; Polymorphism, Single Nucleotide ; Reactive Oxygen Species - metabolism ; Risk Factors ; Singapore ; smoking ; Smoking - genetics ; Smoking - metabolism ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tropical medicine ; Tumors ; X-ray Repair Cross Complementing Protein 1 ; XRCC1</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2007-11, Vol.16 (11), p.2363-2372</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-1222b16c8e3fc776d2bec46e5bdb46b2dd6daa50ab705204b89888d0bec26af53</citedby><cites>FETCH-LOGICAL-c449t-1222b16c8e3fc776d2bec46e5bdb46b2dd6daa50ab705204b89888d0bec26af53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19886237$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18006925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STERN, Mariana C</creatorcontrib><creatorcontrib>CONTI, David V</creatorcontrib><creatorcontrib>SIEGMUND, Kimberly D</creatorcontrib><creatorcontrib>CORRAL, Roman</creatorcontrib><creatorcontrib>YUAN, Jian-Min</creatorcontrib><creatorcontrib>KOH, Woon-Puay</creatorcontrib><creatorcontrib>YU, Mimi C</creatorcontrib><title>DNA Repair Single-Nucleotide Polymorphisms in Colorectal Cancer and their Role as Modifiers of the Effect of Cigarette Smoking and Alcohol in the Singapore Chinese Health Study</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Recently, we reported that among Singapore Chinese, cigarette smoking and alcohol drinking were independent risk factors for
colorectal cancer. Both tobacco smoking and alcohol use are plausible colorectal cancer risk factors, partly due to their
ability to induce mutations in the colorectal lumen. In the present study, we investigated the role in colorectal cancer of
single-nucleotide polymorphisms in five DNA repair genes: XRCC1 (Arg 194 Trp and Arg 399 Gln), PARP (Val 762 Ala, Lys 940 Arg), XPD (Asp 312 Asn, Lys 751 Gln), OGG1 (Ser 326 Cys), and MGMT (Leu 84 Phe). We conducted this study within the Singapore Chinese Health Study, a population-based cohort of 63,257 middle-aged and
older Singapore Chinese men and women enrolled between 1993 and 1998. Our study included 1,176 controls and 310 cases (180
colon and 130 rectum cancer). We observed a positive association between the PARP codon 940 Lys/Arg and Arg/Arg genotypes and colorectal cancer risk [odds ratio (OR), 1.8; 95% confidence interval (95% CI),
1.1-3.1], and an inverse association between the MGMT codon 84 Leu/Phe or Phe/Phe genotypes and colon cancer risk (OR, 0.6; 95% CI, 0.3-0.9), but not rectal cancer (test of heterogeneity
by tumor site, P = 0.027). We observed evidence that XRCC1 may modify the effects of smoking (interaction P = 0.012). The effect of smoking among carriers of the Arg 194 -Gln 399 haplotype was OR = 0.7 (95% CI, 0.4-1.1), whereas, among carriers of the Trp 194 -Arg 399 haplotype, it was OR = 1.6 (95% CI, 1.1-2.5). We also observed a nonstatistically significant modification of XRCC1 on the effects of alcohol ( P = 0.245). Whereas alcohol had no effect among carriers of the codon 194 Arg/Arg (OR, 1.0; 95% CI, 0.6-1.7) or Arg/Trp genotypes
(OR, 1.1; 95% CI, 0.6-1.9), there was a positive association among carriers of the Trp/Trp genotype (OR, 2.8; 95% CI, 1.0-8.1).
Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking
and alcohol on colorectal cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2363–72)</description><subject>Aged</subject><subject>Alcohol Drinking - genetics</subject><subject>Alcohol Drinking - metabolism</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Colorectal</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>DNA Repair</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>PARP</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Risk Factors</subject><subject>Singapore</subject><subject>smoking</subject><subject>Smoking - genetics</subject><subject>Smoking - metabolism</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tropical medicine</subject><subject>Tumors</subject><subject>X-ray Repair Cross Complementing Protein 1</subject><subject>XRCC1</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdGO1CAUhhujcdfVR9Bwo4kXXYEWaC8ndXQ3WdfNjl4TCqdTlJYKbcy8lY8o3Rmzl14B4fvPOfBl2WuCLwlh1QeCGcvrmrPL7d11jkWOKa-eZOeEFVUuBGNP0_4fc5a9iPEHxljUjD3PzkiFMa8pO8_-fLzdoHuYlA1oZ8e9g_x20Q78bA2gO-8Ogw9Tb-MQkR1R450PoGflUKNGDQGp0aC5hxS_9w6QiuiLN7azECLy3XqFtl2XIuupsXsVYJ4B7Qb_M7V7iG-c9r13a_0VX8dQU2qDmt6OEAFdgXJzj3bzYg4vs2edchFendaL7Pun7bfmKr_5-vm62dzkuizrOSeU0pZwXUHRaSG4oS3okgNrTVvylhrDjVIMq1ZgRnHZVnVVVQYninLVseIie3esOwX_a4E4y8FGDc6pEfwSJa9Y8kD4f0GKBROc1wlkR1AHH2OATk7BDiocJMFydSpXX3L1JZNTiYVcnabcm1ODpR3APKZOEhPw9gSoqJXrQjJj4yOXXsZpIRL3_sj1dt__tgGkfnAY0h-roHtJeJpD0oIXxV_r77q1</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>STERN, Mariana C</creator><creator>CONTI, David V</creator><creator>SIEGMUND, Kimberly D</creator><creator>CORRAL, Roman</creator><creator>YUAN, Jian-Min</creator><creator>KOH, Woon-Puay</creator><creator>YU, Mimi C</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>DNA Repair Single-Nucleotide Polymorphisms in Colorectal Cancer and their Role as Modifiers of the Effect of Cigarette Smoking and Alcohol in the Singapore Chinese Health Study</title><author>STERN, Mariana C ; CONTI, David V ; SIEGMUND, Kimberly D ; CORRAL, Roman ; YUAN, Jian-Min ; KOH, Woon-Puay ; YU, Mimi C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-1222b16c8e3fc776d2bec46e5bdb46b2dd6daa50ab705204b89888d0bec26af53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Alcohol Drinking - genetics</topic><topic>Alcohol Drinking - metabolism</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Colorectal</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>DNA Repair</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>PARP</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Risk Factors</topic><topic>Singapore</topic><topic>smoking</topic><topic>Smoking - genetics</topic><topic>Smoking - metabolism</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tropical medicine</topic><topic>Tumors</topic><topic>X-ray Repair Cross Complementing Protein 1</topic><topic>XRCC1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STERN, Mariana C</creatorcontrib><creatorcontrib>CONTI, David V</creatorcontrib><creatorcontrib>SIEGMUND, Kimberly D</creatorcontrib><creatorcontrib>CORRAL, Roman</creatorcontrib><creatorcontrib>YUAN, Jian-Min</creatorcontrib><creatorcontrib>KOH, Woon-Puay</creatorcontrib><creatorcontrib>YU, Mimi C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STERN, Mariana C</au><au>CONTI, David V</au><au>SIEGMUND, Kimberly D</au><au>CORRAL, Roman</au><au>YUAN, Jian-Min</au><au>KOH, Woon-Puay</au><au>YU, Mimi C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA Repair Single-Nucleotide Polymorphisms in Colorectal Cancer and their Role as Modifiers of the Effect of Cigarette Smoking and Alcohol in the Singapore Chinese Health Study</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>16</volume><issue>11</issue><spage>2363</spage><epage>2372</epage><pages>2363-2372</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Recently, we reported that among Singapore Chinese, cigarette smoking and alcohol drinking were independent risk factors for
colorectal cancer. Both tobacco smoking and alcohol use are plausible colorectal cancer risk factors, partly due to their
ability to induce mutations in the colorectal lumen. In the present study, we investigated the role in colorectal cancer of
single-nucleotide polymorphisms in five DNA repair genes: XRCC1 (Arg 194 Trp and Arg 399 Gln), PARP (Val 762 Ala, Lys 940 Arg), XPD (Asp 312 Asn, Lys 751 Gln), OGG1 (Ser 326 Cys), and MGMT (Leu 84 Phe). We conducted this study within the Singapore Chinese Health Study, a population-based cohort of 63,257 middle-aged and
older Singapore Chinese men and women enrolled between 1993 and 1998. Our study included 1,176 controls and 310 cases (180
colon and 130 rectum cancer). We observed a positive association between the PARP codon 940 Lys/Arg and Arg/Arg genotypes and colorectal cancer risk [odds ratio (OR), 1.8; 95% confidence interval (95% CI),
1.1-3.1], and an inverse association between the MGMT codon 84 Leu/Phe or Phe/Phe genotypes and colon cancer risk (OR, 0.6; 95% CI, 0.3-0.9), but not rectal cancer (test of heterogeneity
by tumor site, P = 0.027). We observed evidence that XRCC1 may modify the effects of smoking (interaction P = 0.012). The effect of smoking among carriers of the Arg 194 -Gln 399 haplotype was OR = 0.7 (95% CI, 0.4-1.1), whereas, among carriers of the Trp 194 -Arg 399 haplotype, it was OR = 1.6 (95% CI, 1.1-2.5). We also observed a nonstatistically significant modification of XRCC1 on the effects of alcohol ( P = 0.245). Whereas alcohol had no effect among carriers of the codon 194 Arg/Arg (OR, 1.0; 95% CI, 0.6-1.7) or Arg/Trp genotypes
(OR, 1.1; 95% CI, 0.6-1.9), there was a positive association among carriers of the Trp/Trp genotype (OR, 2.8; 95% CI, 1.0-8.1).
Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking
and alcohol on colorectal cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2363–72)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>18006925</pmid><doi>10.1158/1055-9965.EPI-07-0268</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alcohol Drinking - genetics Alcohol Drinking - metabolism Biological and medical sciences Case-Control Studies Cohort Studies Colorectal Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism DNA Repair DNA-Binding Proteins - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Genotype Humans Male Medical sciences Middle Aged PARP Polymorphism, Single Nucleotide Reactive Oxygen Species - metabolism Risk Factors Singapore smoking Smoking - genetics Smoking - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tropical medicine Tumors X-ray Repair Cross Complementing Protein 1 XRCC1 |
| title | DNA Repair Single-Nucleotide Polymorphisms in Colorectal Cancer and their Role as Modifiers of the Effect of Cigarette Smoking and Alcohol in the Singapore Chinese Health Study |
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