The Link between Graves’ Disease and Hashimoto’s Thyroiditis: A Role for Regulatory T Cells

Hyperthyroidism in Graves’ disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto’s thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies. In some Graves’ patients, thyroiditis becomes sufficiently extensiv...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2007-12, Vol.148 (12), p.5724-5733
Hauptverfasser:	McLachlan, Sandra M, Nagayama, Yuji, Pichurin, Pavel N, Mizutori, Yumiko, Chen, Chun-Rong, Misharin, Alexander, Aliesky, Holly A, Rapoport, Basil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Animals Antibodies Antibody response Autoantibodies Autoantibodies - immunology Autoantigens Autoimmune diseases Biological and medical sciences CD122 antigen CD25 antigen CD4 antigen CD8 antigen Depletion Endocrinopathies Fundamental and applied biological sciences. Psychology Graves disease Graves Disease - immunology Graves Disease - pathology Hashimoto Disease - immunology Hashimoto Disease - pathology Humans Hyperthyroidism Hyperthyroidism - immunology Hyperthyroidism - pathology Hypothyroidism Immunization Immunoglobulins, Thyroid-Stimulating - metabolism Immunohistochemistry Immunological tolerance Immunoregulation Infiltration Iodide peroxidase Lymphocytes Lymphocytes T Medical sciences Mice Mice, Transgenic Non tumoral diseases. Target tissue resistance. Benign neoplasms Peroxidase Receptors, Thyrotropin - genetics Receptors, Thyrotropin - immunology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Thyroglobulin Thyroid Thyroid gland Thyroid Gland - immunology Thyroid Gland - metabolism Thyroid-stimulating hormone Thyroid-stimulating hormone receptors Thyroid. Thyroid axis (diseases) Thyroiditis Thyroxine Transgenic mice Vertebrates: endocrinology
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