Wnt-5a gene expression in malignant human neuroblasts

Neuroblastoma (NB), an embryonal malignancy, poses a major challenge in pediatric oncology for the treatment of disseminated forms. Here, we report the decrease of Wnt-5a gene expression in high-risk NB (HR-NB) as well as in cultured metastatic neuroblasts. Wnt-5a is a member of the Wnt signaling pa...

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Veröffentlicht in:	Cancer letters 2005-10, Vol.228 (1), p.117-123
Hauptverfasser:	Blanc, Etienne, Goldschneider, David, Douc-Rasy, Sétha, Bénard, Jean, Raguénez, Gilda
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cell Differentiation - drug effects Differentiation Gene amplification Gene expression Gene Expression Regulation, Neoplastic Humans Kinases Melanoma Metastatic neuroblastoma Neuroblastoma - enzymology Neuroblastoma - genetics Neuroblastoma - pathology PKC-θ Protein Kinase C - metabolism Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Retinoic acid Signal Transduction Studies Tretinoin - pharmacology Tumors Wnt Proteins - genetics Wnt Proteins - metabolism Wnt-5a Wnt-5a Protein
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