Wnt-5a gene expression in malignant human neuroblasts
Neuroblastoma (NB), an embryonal malignancy, poses a major challenge in pediatric oncology for the treatment of disseminated forms. Here, we report the decrease of Wnt-5a gene expression in high-risk NB (HR-NB) as well as in cultured metastatic neuroblasts. Wnt-5a is a member of the Wnt signaling pa...
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| Veröffentlicht in: | Cancer letters 2005-10, Vol.228 (1), p.117-123 |
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| creator | Blanc, Etienne Goldschneider, David Douc-Rasy, Sétha Bénard, Jean Raguénez, Gilda |
| description | Neuroblastoma (NB), an embryonal malignancy, poses a major challenge in pediatric oncology for the treatment of disseminated forms. Here, we report the decrease of
Wnt-5a gene expression in high-risk NB (HR-NB) as well as in cultured metastatic neuroblasts. Wnt-5a is a member of the Wnt signaling pathway which is mainly associated with patterning decisions in the embryonic nervous system. Moreover, Wnt-5a has been involved in metastatic melanoma progression and invasive ductal breast cancer via adhesion and migration alterations. As retinoic acid (RA) plays a major role in the neural crest induction and differentiation, we showed that RA reverses the aberrant negative regulation of
Wnt-5a in metastatic neuroblasts. While β-catenin expression remained unchanged, PKC-θ, a protein kinase C isoform, was evidenced to increase and parallel
Wnt-5a level. For the first time, the involvement of
Wnt-5a through the Wnt/calcium signaling is highlighted in the pathogenesis of a pediatric embryonal malignancy, NB. |
| doi_str_mv | 10.1016/j.canlet.2004.11.061 |
| format | Article |
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Wnt-5a gene expression in high-risk NB (HR-NB) as well as in cultured metastatic neuroblasts. Wnt-5a is a member of the Wnt signaling pathway which is mainly associated with patterning decisions in the embryonic nervous system. Moreover, Wnt-5a has been involved in metastatic melanoma progression and invasive ductal breast cancer via adhesion and migration alterations. As retinoic acid (RA) plays a major role in the neural crest induction and differentiation, we showed that RA reverses the aberrant negative regulation of
Wnt-5a in metastatic neuroblasts. While β-catenin expression remained unchanged, PKC-θ, a protein kinase C isoform, was evidenced to increase and parallel
Wnt-5a level. For the first time, the involvement of
Wnt-5a through the Wnt/calcium signaling is highlighted in the pathogenesis of a pediatric embryonal malignancy, NB.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2004.11.061</identifier><identifier>PMID: 15925444</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Breast cancer ; Cell Differentiation - drug effects ; Differentiation ; Gene amplification ; Gene expression ; Gene Expression Regulation, Neoplastic ; Humans ; Kinases ; Melanoma ; Metastatic neuroblastoma ; Neuroblastoma - enzymology ; Neuroblastoma - genetics ; Neuroblastoma - pathology ; PKC-θ ; Protein Kinase C - metabolism ; Proteins ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Retinoic acid ; Signal Transduction ; Studies ; Tretinoin - pharmacology ; Tumors ; Wnt Proteins - genetics ; Wnt Proteins - metabolism ; Wnt-5a ; Wnt-5a Protein</subject><ispartof>Cancer letters, 2005-10, Vol.228 (1), p.117-123</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Oct 18, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-f95e62d86df6cbb228aae1b91c804a5d62b033db1bea75937d415844cda1b7ae3</citedby><cites>FETCH-LOGICAL-c419t-f95e62d86df6cbb228aae1b91c804a5d62b033db1bea75937d415844cda1b7ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2004.11.061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15925444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanc, Etienne</creatorcontrib><creatorcontrib>Goldschneider, David</creatorcontrib><creatorcontrib>Douc-Rasy, Sétha</creatorcontrib><creatorcontrib>Bénard, Jean</creatorcontrib><creatorcontrib>Raguénez, Gilda</creatorcontrib><title>Wnt-5a gene expression in malignant human neuroblasts</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Neuroblastoma (NB), an embryonal malignancy, poses a major challenge in pediatric oncology for the treatment of disseminated forms. Here, we report the decrease of
Wnt-5a gene expression in high-risk NB (HR-NB) as well as in cultured metastatic neuroblasts. Wnt-5a is a member of the Wnt signaling pathway which is mainly associated with patterning decisions in the embryonic nervous system. Moreover, Wnt-5a has been involved in metastatic melanoma progression and invasive ductal breast cancer via adhesion and migration alterations. As retinoic acid (RA) plays a major role in the neural crest induction and differentiation, we showed that RA reverses the aberrant negative regulation of
Wnt-5a in metastatic neuroblasts. While β-catenin expression remained unchanged, PKC-θ, a protein kinase C isoform, was evidenced to increase and parallel
Wnt-5a level. For the first time, the involvement of
Wnt-5a through the Wnt/calcium signaling is highlighted in the pathogenesis of a pediatric embryonal malignancy, NB.</description><subject>Breast cancer</subject><subject>Cell Differentiation - drug effects</subject><subject>Differentiation</subject><subject>Gene amplification</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Kinases</subject><subject>Melanoma</subject><subject>Metastatic neuroblastoma</subject><subject>Neuroblastoma - enzymology</subject><subject>Neuroblastoma - genetics</subject><subject>Neuroblastoma - pathology</subject><subject>PKC-θ</subject><subject>Protein Kinase C - metabolism</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Retinoic acid</subject><subject>Signal Transduction</subject><subject>Studies</subject><subject>Tretinoin - pharmacology</subject><subject>Tumors</subject><subject>Wnt Proteins - genetics</subject><subject>Wnt Proteins - metabolism</subject><subject>Wnt-5a</subject><subject>Wnt-5a Protein</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtq3EAQRZvgEE_s_EEIAkN2UqrUD7U2BmPyAkM2CV42_ahxepBak24pOH8fDTMQ8MJZ1ebce6nD2FuEBgHVh13jbRpobloA0SA2oPAF26Du2rrrNZyxDXAQNddcnrPXpewAQIpOvmLnKPtWCiE2TN6nuZa2eqBEFT3uM5USp1TFVI12iA_Jprn6uYw2VYmWPLnBlrlcspdbOxR6c7oX7Menj99vv9R33z5_vb25q73Afq63vSTVBq3CVnnn2lZbS-h69BqElUG1DjgPDh3ZTva8CwKlFsIHi66zxC_Y-2PvPk-_FiqzGWPxNAw20bQUo7REBMX_C2IHSmoNK3j1BNxNS07rEwblqkcq3h8ocaR8nkrJtDX7HEeb_xgEc7BvduZo3xzsG0Sz2l9j707lixsp_AuddK_A9RGgVdrvSNkUHyl5CjGTn02Y4vMLfwGFuZZN</recordid><startdate>20051018</startdate><enddate>20051018</enddate><creator>Blanc, Etienne</creator><creator>Goldschneider, David</creator><creator>Douc-Rasy, Sétha</creator><creator>Bénard, Jean</creator><creator>Raguénez, Gilda</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20051018</creationdate><title>Wnt-5a gene expression in malignant human neuroblasts</title><author>Blanc, Etienne ; Goldschneider, David ; Douc-Rasy, Sétha ; Bénard, Jean ; Raguénez, Gilda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-f95e62d86df6cbb228aae1b91c804a5d62b033db1bea75937d415844cda1b7ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Breast cancer</topic><topic>Cell Differentiation - drug effects</topic><topic>Differentiation</topic><topic>Gene amplification</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Kinases</topic><topic>Melanoma</topic><topic>Metastatic neuroblastoma</topic><topic>Neuroblastoma - enzymology</topic><topic>Neuroblastoma - genetics</topic><topic>Neuroblastoma - pathology</topic><topic>PKC-θ</topic><topic>Protein Kinase C - metabolism</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Retinoic acid</topic><topic>Signal Transduction</topic><topic>Studies</topic><topic>Tretinoin - pharmacology</topic><topic>Tumors</topic><topic>Wnt Proteins - genetics</topic><topic>Wnt Proteins - metabolism</topic><topic>Wnt-5a</topic><topic>Wnt-5a Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanc, Etienne</creatorcontrib><creatorcontrib>Goldschneider, David</creatorcontrib><creatorcontrib>Douc-Rasy, Sétha</creatorcontrib><creatorcontrib>Bénard, Jean</creatorcontrib><creatorcontrib>Raguénez, Gilda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanc, Etienne</au><au>Goldschneider, David</au><au>Douc-Rasy, Sétha</au><au>Bénard, Jean</au><au>Raguénez, Gilda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wnt-5a gene expression in malignant human neuroblasts</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2005-10-18</date><risdate>2005</risdate><volume>228</volume><issue>1</issue><spage>117</spage><epage>123</epage><pages>117-123</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Neuroblastoma (NB), an embryonal malignancy, poses a major challenge in pediatric oncology for the treatment of disseminated forms. Here, we report the decrease of
Wnt-5a gene expression in high-risk NB (HR-NB) as well as in cultured metastatic neuroblasts. Wnt-5a is a member of the Wnt signaling pathway which is mainly associated with patterning decisions in the embryonic nervous system. Moreover, Wnt-5a has been involved in metastatic melanoma progression and invasive ductal breast cancer via adhesion and migration alterations. As retinoic acid (RA) plays a major role in the neural crest induction and differentiation, we showed that RA reverses the aberrant negative regulation of
Wnt-5a in metastatic neuroblasts. While β-catenin expression remained unchanged, PKC-θ, a protein kinase C isoform, was evidenced to increase and parallel
Wnt-5a level. For the first time, the involvement of
Wnt-5a through the Wnt/calcium signaling is highlighted in the pathogenesis of a pediatric embryonal malignancy, NB.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15925444</pmid><doi>10.1016/j.canlet.2004.11.061</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Breast cancer Cell Differentiation - drug effects Differentiation Gene amplification Gene expression Gene Expression Regulation, Neoplastic Humans Kinases Melanoma Metastatic neuroblastoma Neuroblastoma - enzymology Neuroblastoma - genetics Neuroblastoma - pathology PKC-θ Protein Kinase C - metabolism Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Retinoic acid Signal Transduction Studies Tretinoin - pharmacology Tumors Wnt Proteins - genetics Wnt Proteins - metabolism Wnt-5a Wnt-5a Protein |
| title | Wnt-5a gene expression in malignant human neuroblasts |
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