Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue
Leptin reduces adiposity and exerts antisteatotic effects on nonadipose tissues. However, the mechanisms underlying leptin effects on lipid metabolism in liver and white adipose tissue have not been fully clarified. Here, we have studied the effects of central leptin administration on key enzymes an...
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| creator | Gallardo, Nilda Bonzón-Kulichenko, Elena Fernández-Agulló, Teresa Moltó, Eduardo Gómez-Alonso, Sergio Blanco, Pablo Carrascosa, José Ma Ros, Manuel Andrés, Antonio |
| description | Leptin reduces adiposity and exerts antisteatotic effects on nonadipose tissues. However, the mechanisms underlying leptin effects on lipid metabolism in liver and white adipose tissue have not been fully clarified. Here, we have studied the effects of central leptin administration on key enzymes and transcription factors involved in lipid metabolism in liver and epididymal adipose tissue. Intracerebroventricular leptin infusion for 7 d did not change leptin plasma levels but decreased triacylglyceride content in liver, epididymal adipose tissue, and plasma. In both tissues this treatment markedly decreased the expression of key enzymes of the de novo fatty acid (FA) synthesis such as acetyl-coenzyme A-carboxylase, FA synthase, and stearoyl-coenzyme A desaturase-1, in parallel with a reduction in mRNA expression of sterol regulatory element binding protein-1c in liver and carbohydrate regulatory element binding protein in adipose tissue. In addition, leptin also decreased phosphoenol-pyruvate carboxykinase-C expression in adipose tissue, an enzyme involved in glyceroneogenesis in this tissue. Central leptin administration down-regulates delta-6-desaturase expression in liver and adipose tissue, in parallel with the decrease of the expression of sterol regulatory element binding protein-1c in liver and peroxisome proliferator activated receptor α in adipose tissue. Finally, leptin treatment, by regulating adipose triglyceride lipase/hormone sensitive lipase/diacylglycerol transferase 1 expression, also established a new partitioning in the FA-triacylglyceride cycling in adipose tissue, increasing lipolysis and probably the FA efflux from this tissue, and favoring in parallel the FA uptake and oxidation in the liver. These results suggest that leptin, acting at central level, exerts tissue-specific effects in limiting fat tissue mass and lipid accumulation in nonadipose tissues, preventing the development of obesity and type 2 diabetes. |
| doi_str_mv | 10.1210/en.2007-0933 |
| format | Article |
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However, the mechanisms underlying leptin effects on lipid metabolism in liver and white adipose tissue have not been fully clarified. Here, we have studied the effects of central leptin administration on key enzymes and transcription factors involved in lipid metabolism in liver and epididymal adipose tissue. Intracerebroventricular leptin infusion for 7 d did not change leptin plasma levels but decreased triacylglyceride content in liver, epididymal adipose tissue, and plasma. In both tissues this treatment markedly decreased the expression of key enzymes of the de novo fatty acid (FA) synthesis such as acetyl-coenzyme A-carboxylase, FA synthase, and stearoyl-coenzyme A desaturase-1, in parallel with a reduction in mRNA expression of sterol regulatory element binding protein-1c in liver and carbohydrate regulatory element binding protein in adipose tissue. In addition, leptin also decreased phosphoenol-pyruvate carboxykinase-C expression in adipose tissue, an enzyme involved in glyceroneogenesis in this tissue. Central leptin administration down-regulates delta-6-desaturase expression in liver and adipose tissue, in parallel with the decrease of the expression of sterol regulatory element binding protein-1c in liver and peroxisome proliferator activated receptor α in adipose tissue. Finally, leptin treatment, by regulating adipose triglyceride lipase/hormone sensitive lipase/diacylglycerol transferase 1 expression, also established a new partitioning in the FA-triacylglyceride cycling in adipose tissue, increasing lipolysis and probably the FA efflux from this tissue, and favoring in parallel the FA uptake and oxidation in the liver. These results suggest that leptin, acting at central level, exerts tissue-specific effects in limiting fat tissue mass and lipid accumulation in nonadipose tissues, preventing the development of obesity and type 2 diabetes.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2007-0933</identifier><identifier>PMID: 17823267</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Acetyl-CoA Carboxylase - genetics ; Acetyl-CoA Carboxylase - metabolism ; Adipose tissue ; Adipose Tissue, White - drug effects ; Adipose Tissue, White - metabolism ; Animals ; Bioaccumulation ; Biological and medical sciences ; Body fat ; Carbohydrates ; Coenzyme A ; Desaturase ; Diabetes mellitus (non-insulin dependent) ; Diglycerides ; Efflux ; Enzymes ; Fatty Acids - blood ; Fatty Acids - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression - drug effects ; Insulin - administration & dosage ; Insulin - pharmacology ; Leptin ; Leptin - administration & dosage ; Leptin - pharmacology ; Linoleoyl-CoA Desaturase - genetics ; Linoleoyl-CoA Desaturase - metabolism ; Lipase ; Lipid metabolism ; Lipid Metabolism - drug effects ; Lipid Metabolism - genetics ; Lipids ; Lipids. Glycolipids ; Lipolysis ; Liver ; Liver - drug effects ; Liver - metabolism ; Metabolism ; Metabolisms and neurohumoral controls ; Oxidation ; Plasma levels ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; Proteins ; Pyruvic acid ; Rats ; Rats, Wistar ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Stearoyl-CoA Desaturase - genetics ; Stearoyl-CoA Desaturase - metabolism ; Sterol Regulatory Element Binding Protein 1 - genetics ; Sterol Regulatory Element Binding Protein 1 - metabolism ; Sterol regulatory element-binding protein ; Sterols ; Transcription factors ; Triglycerides ; Triglycerides - blood ; Triglycerides - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2007-12, Vol.148 (12), p.5604-5610</ispartof><rights>Copyright © 2007 by The Endocrine Society 2007</rights><rights>2008 INIST-CNRS</rights><rights>Copyright © 2007 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-ed32cda2fe144feafcab169f40a3057487f05c8522532061a53d11944737659c3</citedby><cites>FETCH-LOGICAL-c558t-ed32cda2fe144feafcab169f40a3057487f05c8522532061a53d11944737659c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19861829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17823267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallardo, Nilda</creatorcontrib><creatorcontrib>Bonzón-Kulichenko, Elena</creatorcontrib><creatorcontrib>Fernández-Agulló, Teresa</creatorcontrib><creatorcontrib>Moltó, Eduardo</creatorcontrib><creatorcontrib>Gómez-Alonso, Sergio</creatorcontrib><creatorcontrib>Blanco, Pablo</creatorcontrib><creatorcontrib>Carrascosa, José Ma</creatorcontrib><creatorcontrib>Ros, Manuel</creatorcontrib><creatorcontrib>Andrés, Antonio</creatorcontrib><title>Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Leptin reduces adiposity and exerts antisteatotic effects on nonadipose tissues. However, the mechanisms underlying leptin effects on lipid metabolism in liver and white adipose tissue have not been fully clarified. Here, we have studied the effects of central leptin administration on key enzymes and transcription factors involved in lipid metabolism in liver and epididymal adipose tissue. Intracerebroventricular leptin infusion for 7 d did not change leptin plasma levels but decreased triacylglyceride content in liver, epididymal adipose tissue, and plasma. In both tissues this treatment markedly decreased the expression of key enzymes of the de novo fatty acid (FA) synthesis such as acetyl-coenzyme A-carboxylase, FA synthase, and stearoyl-coenzyme A desaturase-1, in parallel with a reduction in mRNA expression of sterol regulatory element binding protein-1c in liver and carbohydrate regulatory element binding protein in adipose tissue. In addition, leptin also decreased phosphoenol-pyruvate carboxykinase-C expression in adipose tissue, an enzyme involved in glyceroneogenesis in this tissue. Central leptin administration down-regulates delta-6-desaturase expression in liver and adipose tissue, in parallel with the decrease of the expression of sterol regulatory element binding protein-1c in liver and peroxisome proliferator activated receptor α in adipose tissue. Finally, leptin treatment, by regulating adipose triglyceride lipase/hormone sensitive lipase/diacylglycerol transferase 1 expression, also established a new partitioning in the FA-triacylglyceride cycling in adipose tissue, increasing lipolysis and probably the FA efflux from this tissue, and favoring in parallel the FA uptake and oxidation in the liver. These results suggest that leptin, acting at central level, exerts tissue-specific effects in limiting fat tissue mass and lipid accumulation in nonadipose tissues, preventing the development of obesity and type 2 diabetes.</description><subject>Acetyl-CoA Carboxylase - genetics</subject><subject>Acetyl-CoA Carboxylase - metabolism</subject><subject>Adipose tissue</subject><subject>Adipose Tissue, White - drug effects</subject><subject>Adipose Tissue, White - metabolism</subject><subject>Animals</subject><subject>Bioaccumulation</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Carbohydrates</subject><subject>Coenzyme A</subject><subject>Desaturase</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diglycerides</subject><subject>Efflux</subject><subject>Enzymes</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - pharmacology</subject><subject>Leptin</subject><subject>Leptin - administration & dosage</subject><subject>Leptin - pharmacology</subject><subject>Linoleoyl-CoA Desaturase - genetics</subject><subject>Linoleoyl-CoA Desaturase - metabolism</subject><subject>Lipase</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipids</subject><subject>Lipids. Glycolipids</subject><subject>Lipolysis</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Metabolism</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Oxidation</subject><subject>Plasma levels</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Proteins</subject><subject>Pyruvic acid</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Stearoyl-CoA Desaturase - genetics</subject><subject>Stearoyl-CoA Desaturase - metabolism</subject><subject>Sterol Regulatory Element Binding Protein 1 - genetics</subject><subject>Sterol Regulatory Element Binding Protein 1 - metabolism</subject><subject>Sterol regulatory element-binding protein</subject><subject>Sterols</subject><subject>Transcription factors</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Triglycerides - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c2L1DAUAPAgiju7evMsAXG92DUfTZMel2FcF0Y8uOKxZJIXNksnqUk76Nl_3IwtDIjiKbzw430i9IKSK8ooeQfhihEiK9Jy_gitaFuLSlJJHqMVIZRXkjF5hs5zfihhXdf8KTqjUjHOGrlCP-98zhNUnwcw3nmDN86BGTOODq8hjEn3eAvD6AOOAY_3gDffhwQ5-xIWcwMBMr4Nh9gfwOLCtn7wFn-EUe9i7_N-_jtAwjpY_PXej4CvrR9iBjwXf4aeON1neL68F-jL-83d-kO1_XRzu77eVkYINVZgOTNWMwdlDAfaGb2jTetqojkRslbSEWGUYExwRhqqBbe0rKOWXDaiNfwCXc55hxS_TZDHbu-zgb7XAeKUu0YJShrG_wvLvpmqaVvgqz_gQ5xSKEN0nJamlGi4KOrtrEyKOSdw3ZD8XqcfHSXd8YYdhGNO2R1vWPjLJem024M94eVoBbxegM5G9y7pYHw-uVY1VLFjd29mF6fhXyWrpSSfJQQbTfIBft_4NM1fG_0FZFu_wg</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Gallardo, Nilda</creator><creator>Bonzón-Kulichenko, Elena</creator><creator>Fernández-Agulló, Teresa</creator><creator>Moltó, Eduardo</creator><creator>Gómez-Alonso, Sergio</creator><creator>Blanco, Pablo</creator><creator>Carrascosa, José Ma</creator><creator>Ros, Manuel</creator><creator>Andrés, Antonio</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue</title><author>Gallardo, Nilda ; Bonzón-Kulichenko, Elena ; Fernández-Agulló, Teresa ; Moltó, Eduardo ; Gómez-Alonso, Sergio ; Blanco, Pablo ; Carrascosa, José Ma ; Ros, Manuel ; Andrés, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-ed32cda2fe144feafcab169f40a3057487f05c8522532061a53d11944737659c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acetyl-CoA Carboxylase - genetics</topic><topic>Acetyl-CoA Carboxylase - metabolism</topic><topic>Adipose tissue</topic><topic>Adipose Tissue, White - drug effects</topic><topic>Adipose Tissue, White - metabolism</topic><topic>Animals</topic><topic>Bioaccumulation</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Carbohydrates</topic><topic>Coenzyme A</topic><topic>Desaturase</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diglycerides</topic><topic>Efflux</topic><topic>Enzymes</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression - drug effects</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - pharmacology</topic><topic>Leptin</topic><topic>Leptin - administration & dosage</topic><topic>Leptin - pharmacology</topic><topic>Linoleoyl-CoA Desaturase - genetics</topic><topic>Linoleoyl-CoA Desaturase - metabolism</topic><topic>Lipase</topic><topic>Lipid metabolism</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipid Metabolism - genetics</topic><topic>Lipids</topic><topic>Lipids. Glycolipids</topic><topic>Lipolysis</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Metabolism</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Oxidation</topic><topic>Plasma levels</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Proteins</topic><topic>Pyruvic acid</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Stearoyl-CoA Desaturase - genetics</topic><topic>Stearoyl-CoA Desaturase - metabolism</topic><topic>Sterol Regulatory Element Binding Protein 1 - genetics</topic><topic>Sterol Regulatory Element Binding Protein 1 - metabolism</topic><topic>Sterol regulatory element-binding protein</topic><topic>Sterols</topic><topic>Transcription factors</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><topic>Triglycerides - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallardo, Nilda</creatorcontrib><creatorcontrib>Bonzón-Kulichenko, Elena</creatorcontrib><creatorcontrib>Fernández-Agulló, Teresa</creatorcontrib><creatorcontrib>Moltó, Eduardo</creatorcontrib><creatorcontrib>Gómez-Alonso, Sergio</creatorcontrib><creatorcontrib>Blanco, Pablo</creatorcontrib><creatorcontrib>Carrascosa, José Ma</creatorcontrib><creatorcontrib>Ros, Manuel</creatorcontrib><creatorcontrib>Andrés, Antonio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallardo, Nilda</au><au>Bonzón-Kulichenko, Elena</au><au>Fernández-Agulló, Teresa</au><au>Moltó, Eduardo</au><au>Gómez-Alonso, Sergio</au><au>Blanco, Pablo</au><au>Carrascosa, José Ma</au><au>Ros, Manuel</au><au>Andrés, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>148</volume><issue>12</issue><spage>5604</spage><epage>5610</epage><pages>5604-5610</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Leptin reduces adiposity and exerts antisteatotic effects on nonadipose tissues. However, the mechanisms underlying leptin effects on lipid metabolism in liver and white adipose tissue have not been fully clarified. Here, we have studied the effects of central leptin administration on key enzymes and transcription factors involved in lipid metabolism in liver and epididymal adipose tissue. Intracerebroventricular leptin infusion for 7 d did not change leptin plasma levels but decreased triacylglyceride content in liver, epididymal adipose tissue, and plasma. In both tissues this treatment markedly decreased the expression of key enzymes of the de novo fatty acid (FA) synthesis such as acetyl-coenzyme A-carboxylase, FA synthase, and stearoyl-coenzyme A desaturase-1, in parallel with a reduction in mRNA expression of sterol regulatory element binding protein-1c in liver and carbohydrate regulatory element binding protein in adipose tissue. In addition, leptin also decreased phosphoenol-pyruvate carboxykinase-C expression in adipose tissue, an enzyme involved in glyceroneogenesis in this tissue. Central leptin administration down-regulates delta-6-desaturase expression in liver and adipose tissue, in parallel with the decrease of the expression of sterol regulatory element binding protein-1c in liver and peroxisome proliferator activated receptor α in adipose tissue. Finally, leptin treatment, by regulating adipose triglyceride lipase/hormone sensitive lipase/diacylglycerol transferase 1 expression, also established a new partitioning in the FA-triacylglyceride cycling in adipose tissue, increasing lipolysis and probably the FA efflux from this tissue, and favoring in parallel the FA uptake and oxidation in the liver. These results suggest that leptin, acting at central level, exerts tissue-specific effects in limiting fat tissue mass and lipid accumulation in nonadipose tissues, preventing the development of obesity and type 2 diabetes.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>17823267</pmid><doi>10.1210/en.2007-0933</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acetyl-CoA Carboxylase - genetics Acetyl-CoA Carboxylase - metabolism Adipose tissue Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Animals Bioaccumulation Biological and medical sciences Body fat Carbohydrates Coenzyme A Desaturase Diabetes mellitus (non-insulin dependent) Diglycerides Efflux Enzymes Fatty Acids - blood Fatty Acids - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Insulin - administration & dosage Insulin - pharmacology Leptin Leptin - administration & dosage Leptin - pharmacology Linoleoyl-CoA Desaturase - genetics Linoleoyl-CoA Desaturase - metabolism Lipase Lipid metabolism Lipid Metabolism - drug effects Lipid Metabolism - genetics Lipids Lipids. Glycolipids Lipolysis Liver Liver - drug effects Liver - metabolism Metabolism Metabolisms and neurohumoral controls Oxidation Plasma levels Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Pyruvic acid Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Stearoyl-CoA Desaturase - genetics Stearoyl-CoA Desaturase - metabolism Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterol regulatory element-binding protein Sterols Transcription factors Triglycerides Triglycerides - blood Triglycerides - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue |
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