Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature
Abstract Background Inflammatory myofibroblastic tumor (IMT) of the heart is extremely rare with unpredictable clinical expression. IMTs, characterized by spindle cells, plasma cells, and a polymorphic inflammatory infiltrate, have a predilection for children and young adults. Clinically, IMT mimics...
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| Veröffentlicht in: | Cardiovascular pathology 2007-11, Vol.16 (6), p.359-364 |
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| creator | Butany, Jagdish Dixit, Vidya Leong, Shaun W Daniel, Lorretta B Mezody, Mellita David, Tirone E |
| description | Abstract Background Inflammatory myofibroblastic tumor (IMT) of the heart is extremely rare with unpredictable clinical expression. IMTs, characterized by spindle cells, plasma cells, and a polymorphic inflammatory infiltrate, have a predilection for children and young adults. Clinically, IMT mimics malignancy, making a definitive diagnosis difficult, prior to histopathological examination. Methods and results We describe a case of an intracardiac IMT in a 69-year-old woman. Histopathological examination of excised specimens revealed a marked, polymorphic, infiltrate of lymphocytes and plasma cells. Conclusions Cardiac IMTs are benign lesions with favorable prognosis. Herein, we present this case, along with a review of all cardiac IMTs published after the last review in 2002, with emphasis on clinical, pathologic, and immunohistochemical features. |
| doi_str_mv | 10.1016/j.carpath.2007.01.008 |
| format | Article |
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IMTs, characterized by spindle cells, plasma cells, and a polymorphic inflammatory infiltrate, have a predilection for children and young adults. Clinically, IMT mimics malignancy, making a definitive diagnosis difficult, prior to histopathological examination. Methods and results We describe a case of an intracardiac IMT in a 69-year-old woman. Histopathological examination of excised specimens revealed a marked, polymorphic, infiltrate of lymphocytes and plasma cells. Conclusions Cardiac IMTs are benign lesions with favorable prognosis. Herein, we present this case, along with a review of all cardiac IMTs published after the last review in 2002, with emphasis on clinical, pathologic, and immunohistochemical features.</description><identifier>ISSN: 1054-8807</identifier><identifier>EISSN: 1879-1336</identifier><identifier>DOI: 10.1016/j.carpath.2007.01.008</identifier><identifier>PMID: 18005877</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aortic Valve - pathology ; Cardiac neoplasm ; Cardiac Surgical Procedures ; Diagnosis, Differential ; Echocardiography ; Female ; Heart Neoplasms - pathology ; Heart Neoplasms - surgery ; Humans ; Inflammation - pathology ; Inflammation - surgery ; Inflammatory myofibroblastic tumor (IMT) ; Inflammatory pseudotumor (IP) ; Lymphocytes - pathology ; Mitral Valve - pathology ; Myofibroma - pathology ; Myofibroma - surgery ; Pathology ; Plasma Cells - pathology ; Treatment Outcome</subject><ispartof>Cardiovascular pathology, 2007-11, Vol.16 (6), p.359-364</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-ed004f1e6b08a53d9a1e1d17bc12958a222f9d6d25c2a03659f1f0ba803816c83</citedby><cites>FETCH-LOGICAL-c418t-ed004f1e6b08a53d9a1e1d17bc12958a222f9d6d25c2a03659f1f0ba803816c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1054880707000336$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18005877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butany, Jagdish</creatorcontrib><creatorcontrib>Dixit, Vidya</creatorcontrib><creatorcontrib>Leong, Shaun W</creatorcontrib><creatorcontrib>Daniel, Lorretta B</creatorcontrib><creatorcontrib>Mezody, Mellita</creatorcontrib><creatorcontrib>David, Tirone E</creatorcontrib><title>Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature</title><title>Cardiovascular pathology</title><addtitle>Cardiovasc Pathol</addtitle><description>Abstract Background Inflammatory myofibroblastic tumor (IMT) of the heart is extremely rare with unpredictable clinical expression. IMTs, characterized by spindle cells, plasma cells, and a polymorphic inflammatory infiltrate, have a predilection for children and young adults. Clinically, IMT mimics malignancy, making a definitive diagnosis difficult, prior to histopathological examination. Methods and results We describe a case of an intracardiac IMT in a 69-year-old woman. Histopathological examination of excised specimens revealed a marked, polymorphic, infiltrate of lymphocytes and plasma cells. Conclusions Cardiac IMTs are benign lesions with favorable prognosis. Herein, we present this case, along with a review of all cardiac IMTs published after the last review in 2002, with emphasis on clinical, pathologic, and immunohistochemical features.</description><subject>Aged</subject><subject>Aortic Valve - pathology</subject><subject>Cardiac neoplasm</subject><subject>Cardiac Surgical Procedures</subject><subject>Diagnosis, Differential</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Neoplasms - pathology</subject><subject>Heart Neoplasms - surgery</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Inflammation - surgery</subject><subject>Inflammatory myofibroblastic tumor (IMT)</subject><subject>Inflammatory pseudotumor (IP)</subject><subject>Lymphocytes - pathology</subject><subject>Mitral Valve - pathology</subject><subject>Myofibroma - pathology</subject><subject>Myofibroma - surgery</subject><subject>Pathology</subject><subject>Plasma Cells - pathology</subject><subject>Treatment Outcome</subject><issn>1054-8807</issn><issn>1879-1336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhhtR3HX1Jyg5eeu2kv5Ke1CWxY-FBQ_qOVQn1UzGdGdM0r3MvzfDDAheJIfU4akq6nmL4jWHigPv3u0rjeGAaVcJgL4CXgHIJ8U1l_1Q8rrunuYa2qaUEvqr4kWMe8hE0zTPiysuAVrZ99fF7n6ZHM4zJh-ObD76yY7Bjw5jspqldfaBPdq0Yxu6bXUYmF027zaaaUnvGTKNkViggw-J4WJyuVl6ZH5iaUfM2UQB0xroZfFsQhfp1eW_KX5-_vTj7mv58O3L_d3tQ6kbLlNJBqCZOHUjSGxrMyAnbng_ai6GVqIQYhpMZ0SrBULdtcPEJxhRQi15p2V9U7w9zz0E_3ulmNRsoybncCG_RtXJFgYAkcH2DOrgYww0qUOwM4aj4qBOitVeXRSrk2IFXGWBue_NZcE6zmT-dl2cZuDjGaB8ZpYRVNSWFk3GBtJJGW__u-LDPxO0s4vV6H7RkeLer2HJDhVXUShQ3085n2LODyBHX_8Bmm-mXg</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Butany, Jagdish</creator><creator>Dixit, Vidya</creator><creator>Leong, Shaun W</creator><creator>Daniel, Lorretta B</creator><creator>Mezody, Mellita</creator><creator>David, Tirone E</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature</title><author>Butany, Jagdish ; Dixit, Vidya ; Leong, Shaun W ; Daniel, Lorretta B ; Mezody, Mellita ; David, Tirone E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-ed004f1e6b08a53d9a1e1d17bc12958a222f9d6d25c2a03659f1f0ba803816c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aortic Valve - pathology</topic><topic>Cardiac neoplasm</topic><topic>Cardiac Surgical Procedures</topic><topic>Diagnosis, Differential</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Neoplasms - pathology</topic><topic>Heart Neoplasms - surgery</topic><topic>Humans</topic><topic>Inflammation - pathology</topic><topic>Inflammation - surgery</topic><topic>Inflammatory myofibroblastic tumor (IMT)</topic><topic>Inflammatory pseudotumor (IP)</topic><topic>Lymphocytes - pathology</topic><topic>Mitral Valve - pathology</topic><topic>Myofibroma - pathology</topic><topic>Myofibroma - surgery</topic><topic>Pathology</topic><topic>Plasma Cells - pathology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butany, Jagdish</creatorcontrib><creatorcontrib>Dixit, Vidya</creatorcontrib><creatorcontrib>Leong, Shaun W</creatorcontrib><creatorcontrib>Daniel, Lorretta B</creatorcontrib><creatorcontrib>Mezody, Mellita</creatorcontrib><creatorcontrib>David, Tirone E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butany, Jagdish</au><au>Dixit, Vidya</au><au>Leong, Shaun W</au><au>Daniel, Lorretta B</au><au>Mezody, Mellita</au><au>David, Tirone E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature</atitle><jtitle>Cardiovascular pathology</jtitle><addtitle>Cardiovasc Pathol</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>16</volume><issue>6</issue><spage>359</spage><epage>364</epage><pages>359-364</pages><issn>1054-8807</issn><eissn>1879-1336</eissn><abstract>Abstract Background Inflammatory myofibroblastic tumor (IMT) of the heart is extremely rare with unpredictable clinical expression. IMTs, characterized by spindle cells, plasma cells, and a polymorphic inflammatory infiltrate, have a predilection for children and young adults. Clinically, IMT mimics malignancy, making a definitive diagnosis difficult, prior to histopathological examination. Methods and results We describe a case of an intracardiac IMT in a 69-year-old woman. Histopathological examination of excised specimens revealed a marked, polymorphic, infiltrate of lymphocytes and plasma cells. Conclusions Cardiac IMTs are benign lesions with favorable prognosis. Herein, we present this case, along with a review of all cardiac IMTs published after the last review in 2002, with emphasis on clinical, pathologic, and immunohistochemical features.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18005877</pmid><doi>10.1016/j.carpath.2007.01.008</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cardiovascular pathology, 2007-11, Vol.16 (6), p.359-364 |
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| subjects | Aged Aortic Valve - pathology Cardiac neoplasm Cardiac Surgical Procedures Diagnosis, Differential Echocardiography Female Heart Neoplasms - pathology Heart Neoplasms - surgery Humans Inflammation - pathology Inflammation - surgery Inflammatory myofibroblastic tumor (IMT) Inflammatory pseudotumor (IP) Lymphocytes - pathology Mitral Valve - pathology Myofibroma - pathology Myofibroma - surgery Pathology Plasma Cells - pathology Treatment Outcome |
| title | Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature |
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