N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors
A variety of N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides of general structure 10 were designed, synthesized, and evaluated as histone deacetylase (HDAC) inhibitors. A variety of N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inh...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2007-12, Vol.17 (24), p.6729-6733 |
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| creator | Vaisburg, Arkadii Paquin, Isabelle Bernstein, Naomy Frechette, Sylvie Gaudette, Frederic Leit, Silvana Moradei, Oscar Raeppel, Stephane Zhou, Nancy Bouchain, Giliane Woo, Soon Hyung Jin, Zhiyun Gillespie, Jeff Wang, James Fournel, Marielle Yan, Pu Theresa Trachy-Bourget, Marie-Claude Robert, Marie-France Lu, Aihua Yuk, Jimmy Rahil, Jubrail MacLeod, A. Robert Besterman, Jeffrey M. Li, Zuomei Delorme, Daniel |
| description | A variety of
N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides of general structure
10 were designed, synthesized, and evaluated as histone deacetylase (HDAC) inhibitors.
A variety of
N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC
50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21
WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice. |
| doi_str_mv | 10.1016/j.bmcl.2007.10.050 |
| format | Article |
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N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides of general structure
10 were designed, synthesized, and evaluated as histone deacetylase (HDAC) inhibitors.
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N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC
50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21
WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2007.10.050</identifier><identifier>PMID: 17977726</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amination ; Animals ; Antineoplastic agents ; Benzamides ; Benzamides - chemistry ; Benzamides - pharmacology ; Binding Sites ; Biological and medical sciences ; Cancer cell proliferation ; Cell Line ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; General aspects ; HDAC ; Histone Deacetylase Inhibitors ; Histone Deacetylases - chemistry ; Histone Deacetylases - metabolism ; Humans ; Medical sciences ; Methylation ; Mice ; Models, Molecular ; Molecular Structure ; Niacin - pharmacology ; ortho-Aminobenzoates - chemistry ; Pharmacology. Drug treatments ; Structure-Activity Relationship ; Urea - chemistry ; Vasodilation - drug effects</subject><ispartof>Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6729-6733</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3369f526bc6fadcdc2f5fa46f5b25f3722f901a3107bb8dcdbe23015a6945d823</citedby><cites>FETCH-LOGICAL-c415t-3369f526bc6fadcdc2f5fa46f5b25f3722f901a3107bb8dcdbe23015a6945d823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2007.10.050$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19690665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17977726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaisburg, Arkadii</creatorcontrib><creatorcontrib>Paquin, Isabelle</creatorcontrib><creatorcontrib>Bernstein, Naomy</creatorcontrib><creatorcontrib>Frechette, Sylvie</creatorcontrib><creatorcontrib>Gaudette, Frederic</creatorcontrib><creatorcontrib>Leit, Silvana</creatorcontrib><creatorcontrib>Moradei, Oscar</creatorcontrib><creatorcontrib>Raeppel, Stephane</creatorcontrib><creatorcontrib>Zhou, Nancy</creatorcontrib><creatorcontrib>Bouchain, Giliane</creatorcontrib><creatorcontrib>Woo, Soon Hyung</creatorcontrib><creatorcontrib>Jin, Zhiyun</creatorcontrib><creatorcontrib>Gillespie, Jeff</creatorcontrib><creatorcontrib>Wang, James</creatorcontrib><creatorcontrib>Fournel, Marielle</creatorcontrib><creatorcontrib>Yan, Pu Theresa</creatorcontrib><creatorcontrib>Trachy-Bourget, Marie-Claude</creatorcontrib><creatorcontrib>Robert, Marie-France</creatorcontrib><creatorcontrib>Lu, Aihua</creatorcontrib><creatorcontrib>Yuk, Jimmy</creatorcontrib><creatorcontrib>Rahil, Jubrail</creatorcontrib><creatorcontrib>MacLeod, A. Robert</creatorcontrib><creatorcontrib>Besterman, Jeffrey M.</creatorcontrib><creatorcontrib>Li, Zuomei</creatorcontrib><creatorcontrib>Delorme, Daniel</creatorcontrib><title>N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A variety of
N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides of general structure
10 were designed, synthesized, and evaluated as histone deacetylase (HDAC) inhibitors.
A variety of
N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC
50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21
WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.</description><subject>Amination</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Benzamides</subject><subject>Benzamides - chemistry</subject><subject>Benzamides - pharmacology</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Cancer cell proliferation</subject><subject>Cell Line</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>General aspects</subject><subject>HDAC</subject><subject>Histone Deacetylase Inhibitors</subject><subject>Histone Deacetylases - chemistry</subject><subject>Histone Deacetylases - metabolism</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Methylation</subject><subject>Mice</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Niacin - pharmacology</subject><subject>ortho-Aminobenzoates - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Structure-Activity Relationship</subject><subject>Urea - chemistry</subject><subject>Vasodilation - drug effects</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAUhUVpaCZp_0AXxZuGdKGpJOsxgm5C6AtCumkhOyHJV1iDLU8lT8rk11dmBrJrVxcO3zlcPoTeUrKmhMqP27Ub_bBmhKgarIkgL9CKcslxy4l4iVZES4I3mj-co4tStoRQTjh_hc6p0kopJlfo4R5fM3wzxjThXQ_pMHzAHF_3MEOebD4MI8z9EjpIT3aMHZTGlibBn6aPZZ4SNB1YD_NhsAWamPro4jzl8hqdBTsUeHO6l-jXl88_b7_hux9fv9_e3GHPqZhx20odBJPOy2A733kWRLBcBuGYCK1iLGhCbUuJcm5TAQesJVRYqbnoNqy9RFfH3V2efu-hzGaMxcMw2ATTvhi5EUQxJf8LUq2obmVbQXYEfZ5KyRDMLsexujCUmEW82ZpFvFnEL1kVX0vvTut7N0L3XDmZrsD7E2CLt0PINvlYnjktNZFSVO7TkYMq7TFCNsVHSB66mMHPppviv_74CyWroR4</recordid><startdate>20071215</startdate><enddate>20071215</enddate><creator>Vaisburg, Arkadii</creator><creator>Paquin, Isabelle</creator><creator>Bernstein, Naomy</creator><creator>Frechette, Sylvie</creator><creator>Gaudette, Frederic</creator><creator>Leit, Silvana</creator><creator>Moradei, Oscar</creator><creator>Raeppel, Stephane</creator><creator>Zhou, Nancy</creator><creator>Bouchain, Giliane</creator><creator>Woo, Soon Hyung</creator><creator>Jin, Zhiyun</creator><creator>Gillespie, Jeff</creator><creator>Wang, James</creator><creator>Fournel, Marielle</creator><creator>Yan, Pu Theresa</creator><creator>Trachy-Bourget, Marie-Claude</creator><creator>Robert, Marie-France</creator><creator>Lu, Aihua</creator><creator>Yuk, Jimmy</creator><creator>Rahil, Jubrail</creator><creator>MacLeod, A. 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Robert</au><au>Besterman, Jeffrey M.</au><au>Li, Zuomei</au><au>Delorme, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2007-12-15</date><risdate>2007</risdate><volume>17</volume><issue>24</issue><spage>6729</spage><epage>6733</epage><pages>6729-6733</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>A variety of
N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides of general structure
10 were designed, synthesized, and evaluated as histone deacetylase (HDAC) inhibitors.
A variety of
N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC
50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21
WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17977726</pmid><doi>10.1016/j.bmcl.2007.10.050</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6729-6733 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68507276 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amination Animals Antineoplastic agents Benzamides Benzamides - chemistry Benzamides - pharmacology Binding Sites Biological and medical sciences Cancer cell proliferation Cell Line Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects HDAC Histone Deacetylase Inhibitors Histone Deacetylases - chemistry Histone Deacetylases - metabolism Humans Medical sciences Methylation Mice Models, Molecular Molecular Structure Niacin - pharmacology ortho-Aminobenzoates - chemistry Pharmacology. Drug treatments Structure-Activity Relationship Urea - chemistry Vasodilation - drug effects |
| title | N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors |
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