Regions of interest in FTIR imaging applications: Diffusion of nicotine into ethylene-co-vinyl acetate films
Effective image analysis of dynamic processes, such as diffusion and dissolution, requires precise reporting of component locations in space and time. An improved method for analyzing FTIR images is described which employs hypothesis testing in the spatial and temporal domains. Changes in the observ...
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| Veröffentlicht in: | Journal of controlled release 2005-09, Vol.106 (3), p.329-338 |
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| container_end_page | 338 |
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| container_title | Journal of controlled release |
| container_volume | 106 |
| creator | Bobiak, J.P. Koenig, J.L. |
| description | Effective image analysis of dynamic processes, such as diffusion and dissolution, requires precise reporting of component locations in space and time. An improved method for analyzing FTIR images is described which employs hypothesis testing in the spatial and temporal domains. Changes in the observed absorbance (over space and time) are revealed by comparison to a reference statistic, which can be tailored by choosing the size of a region of interest. This improved analysis method was used to compare the rates of diffusion of nicotine into poly(ethylene-co-vinyl acetate) film from aqueous solutions containing anionic and nonionic surfactants. Compared to a solution without surfactant, sodium dodecyl sulfate inhibited the uptake of nicotine from aqueous solution whereas Tween 40 enhanced the uptake. The nicotine diffusion rate also showed a dependence on the length of the hydrophobic segment of nonionic surfactants. These results demonstrate the roles of solubilization, wetting, and viscosity on diffusion-controlled drug release. |
| doi_str_mv | 10.1016/j.jconrel.2005.05.011 |
| format | Article |
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An improved method for analyzing FTIR images is described which employs hypothesis testing in the spatial and temporal domains. Changes in the observed absorbance (over space and time) are revealed by comparison to a reference statistic, which can be tailored by choosing the size of a region of interest. This improved analysis method was used to compare the rates of diffusion of nicotine into poly(ethylene-co-vinyl acetate) film from aqueous solutions containing anionic and nonionic surfactants. Compared to a solution without surfactant, sodium dodecyl sulfate inhibited the uptake of nicotine from aqueous solution whereas Tween 40 enhanced the uptake. The nicotine diffusion rate also showed a dependence on the length of the hydrophobic segment of nonionic surfactants. These results demonstrate the roles of solubilization, wetting, and viscosity on diffusion-controlled drug release.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2005.05.011</identifier><identifier>PMID: 16002172</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Diffusion ; Ethylene-co-vinyl acetate ; FTIR imaging ; General pharmacology ; Medical sciences ; Nicotine ; Nicotine - administration & dosage ; Nicotine - chemistry ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polyvinyls - administration & dosage ; Polyvinyls - chemistry ; Regions of interest (ROI) ; Solubility ; Spectroscopy, Fourier Transform Infrared</subject><ispartof>Journal of controlled release, 2005-09, Vol.106 (3), p.329-338</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-133a6168cc2d581e7af8e30849deb11d8d95d71139360d5d8a5b24753a560bd13</citedby><cites>FETCH-LOGICAL-c450t-133a6168cc2d581e7af8e30849deb11d8d95d71139360d5d8a5b24753a560bd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2005.05.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17067499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16002172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bobiak, J.P.</creatorcontrib><creatorcontrib>Koenig, J.L.</creatorcontrib><title>Regions of interest in FTIR imaging applications: Diffusion of nicotine into ethylene-co-vinyl acetate films</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Effective image analysis of dynamic processes, such as diffusion and dissolution, requires precise reporting of component locations in space and time. An improved method for analyzing FTIR images is described which employs hypothesis testing in the spatial and temporal domains. Changes in the observed absorbance (over space and time) are revealed by comparison to a reference statistic, which can be tailored by choosing the size of a region of interest. This improved analysis method was used to compare the rates of diffusion of nicotine into poly(ethylene-co-vinyl acetate) film from aqueous solutions containing anionic and nonionic surfactants. Compared to a solution without surfactant, sodium dodecyl sulfate inhibited the uptake of nicotine from aqueous solution whereas Tween 40 enhanced the uptake. The nicotine diffusion rate also showed a dependence on the length of the hydrophobic segment of nonionic surfactants. These results demonstrate the roles of solubilization, wetting, and viscosity on diffusion-controlled drug release.</description><subject>Biological and medical sciences</subject><subject>Diffusion</subject><subject>Ethylene-co-vinyl acetate</subject><subject>FTIR imaging</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Nicotine</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotine - chemistry</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyvinyls - administration & dosage</subject><subject>Polyvinyls - chemistry</subject><subject>Regions of interest (ROI)</subject><subject>Solubility</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrGzEQhUVpaZy0P6FFl_a2rma1Wu32UkrapIFAIaRnIUuzrowsudI64H9fCS_kGBjQHL438zSPkA_A1sCg_7Jb70wMCf26ZUysawG8IisYJG-6cRSvyapwQ8N7MV6Qy5x3rIC8k2_JBfSMtSDbFfEPuHUxZBon6sKMCfNcGnrzePdA3V5vXdhSfTh4Z_Rcwa_0h5umYy591QRn4uwCVnGkOP89eQzYmNg8uXDyVBuc9Yx0cn6f35E3k_YZ3y_vFflz8_Px-ldz__v27vr7fWM6weYGONd9sW5Ma8UAKPU0IGdDN1rcANjBjsJKAD7ynllhBy02bScF16JnGwv8inw-zz2k-O9YfqT2Lhv0XgeMx6z6QTAJonsRhLFrZT9WUJxBk2LOCSd1SOU66aSAqZqH2qklD1XzULWgOvm4LDhu9mifVUsABfi0ADob7aekg3H5mZOslyXNwn07c1ju9uQwqWwcBoPWJTSzstG9YOU_ncarxA</recordid><startdate>20050902</startdate><enddate>20050902</enddate><creator>Bobiak, J.P.</creator><creator>Koenig, J.L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050902</creationdate><title>Regions of interest in FTIR imaging applications: Diffusion of nicotine into ethylene-co-vinyl acetate films</title><author>Bobiak, J.P. ; Koenig, J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-133a6168cc2d581e7af8e30849deb11d8d95d71139360d5d8a5b24753a560bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Diffusion</topic><topic>Ethylene-co-vinyl acetate</topic><topic>FTIR imaging</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Nicotine</topic><topic>Nicotine - administration & dosage</topic><topic>Nicotine - chemistry</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyvinyls - administration & dosage</topic><topic>Polyvinyls - chemistry</topic><topic>Regions of interest (ROI)</topic><topic>Solubility</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bobiak, J.P.</creatorcontrib><creatorcontrib>Koenig, J.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bobiak, J.P.</au><au>Koenig, J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regions of interest in FTIR imaging applications: Diffusion of nicotine into ethylene-co-vinyl acetate films</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2005-09-02</date><risdate>2005</risdate><volume>106</volume><issue>3</issue><spage>329</spage><epage>338</epage><pages>329-338</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Effective image analysis of dynamic processes, such as diffusion and dissolution, requires precise reporting of component locations in space and time. An improved method for analyzing FTIR images is described which employs hypothesis testing in the spatial and temporal domains. Changes in the observed absorbance (over space and time) are revealed by comparison to a reference statistic, which can be tailored by choosing the size of a region of interest. This improved analysis method was used to compare the rates of diffusion of nicotine into poly(ethylene-co-vinyl acetate) film from aqueous solutions containing anionic and nonionic surfactants. Compared to a solution without surfactant, sodium dodecyl sulfate inhibited the uptake of nicotine from aqueous solution whereas Tween 40 enhanced the uptake. The nicotine diffusion rate also showed a dependence on the length of the hydrophobic segment of nonionic surfactants. These results demonstrate the roles of solubilization, wetting, and viscosity on diffusion-controlled drug release.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16002172</pmid><doi>10.1016/j.jconrel.2005.05.011</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of controlled release, 2005-09, Vol.106 (3), p.329-338 |
| issn | 0168-3659 1873-4995 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Diffusion Ethylene-co-vinyl acetate FTIR imaging General pharmacology Medical sciences Nicotine Nicotine - administration & dosage Nicotine - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyvinyls - administration & dosage Polyvinyls - chemistry Regions of interest (ROI) Solubility Spectroscopy, Fourier Transform Infrared |
| title | Regions of interest in FTIR imaging applications: Diffusion of nicotine into ethylene-co-vinyl acetate films |
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