Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats
We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control grou...
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| Veröffentlicht in: | Collegium antropologicum 2005-06, Vol.29 (1), p.321-325 |
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| container_title | Collegium antropologicum |
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| creator | Lazić, Ratimir Gabrić, Nikica Dekaris, Iva Bosnar, Damir Boban-Blagaić, Alenka Sikirić, Predrag |
| description | We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent. |
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Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.</description><identifier>ISSN: 0350-6134</identifier><identifier>PMID: 16117343</identifier><language>eng</language><publisher>Croatia</publisher><subject>Animals ; Anti-Ulcer Agents - pharmacology ; Corneal Diseases - drug therapy ; Corneal Diseases - veterinary ; Epithelium ; Male ; Peptide Fragments - pharmacology ; Proteins - pharmacology ; Rats ; Rats, Wistar</subject><ispartof>Collegium antropologicum, 2005-06, Vol.29 (1), p.321-325</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16117343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lazić, Ratimir</creatorcontrib><creatorcontrib>Gabrić, Nikica</creatorcontrib><creatorcontrib>Dekaris, Iva</creatorcontrib><creatorcontrib>Bosnar, Damir</creatorcontrib><creatorcontrib>Boban-Blagaić, Alenka</creatorcontrib><creatorcontrib>Sikirić, Predrag</creatorcontrib><title>Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats</title><title>Collegium antropologicum</title><addtitle>Coll Antropol</addtitle><description>We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Corneal Diseases - drug therapy</subject><subject>Corneal Diseases - veterinary</subject><subject>Epithelium</subject><subject>Male</subject><subject>Peptide Fragments - pharmacology</subject><subject>Proteins - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0350-6134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAYhHNQ3HX1L0hO3gpvkiZpjlp0FRb0sJ5Lmr5xI_2ITXrw31twPc0wPAzDXJAtCAmFYqLckOuUvgCkVqCuyIYpxrQoxZYc9zblOTgaccy2Q2cjxhw6pI_vNWVS0zhPw5QxUTfNI9qeYgz5hH1YbYceXU70tOZh_KRhpLPN6YZcetsnvD3rjnw8Px3rl-Lwtn-tHw5F5GBy0RowbcuYtL4y2nnHXVlJaDXjxragnKoMcO8NMAPWWCM9KFEarqArBYDYkfu_3nXj94IpN0NIDvvejjgtqVFrmwbOV_DuDC7tgF0T5zDY-af5_0H8ApIxV1c</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Lazić, Ratimir</creator><creator>Gabrić, Nikica</creator><creator>Dekaris, Iva</creator><creator>Bosnar, Damir</creator><creator>Boban-Blagaić, Alenka</creator><creator>Sikirić, Predrag</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats</title><author>Lazić, Ratimir ; Gabrić, Nikica ; Dekaris, Iva ; Bosnar, Damir ; Boban-Blagaić, Alenka ; Sikirić, Predrag</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-b909bb115af897cfc2c4850b7129ab06c68902ff90190a9a95f06349260d43003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Corneal Diseases - drug therapy</topic><topic>Corneal Diseases - veterinary</topic><topic>Epithelium</topic><topic>Male</topic><topic>Peptide Fragments - pharmacology</topic><topic>Proteins - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lazić, Ratimir</creatorcontrib><creatorcontrib>Gabrić, Nikica</creatorcontrib><creatorcontrib>Dekaris, Iva</creatorcontrib><creatorcontrib>Bosnar, Damir</creatorcontrib><creatorcontrib>Boban-Blagaić, Alenka</creatorcontrib><creatorcontrib>Sikirić, Predrag</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Collegium antropologicum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lazić, Ratimir</au><au>Gabrić, Nikica</au><au>Dekaris, Iva</au><au>Bosnar, Damir</au><au>Boban-Blagaić, Alenka</au><au>Sikirić, Predrag</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats</atitle><jtitle>Collegium antropologicum</jtitle><addtitle>Coll Antropol</addtitle><date>2005-06</date><risdate>2005</risdate><volume>29</volume><issue>1</issue><spage>321</spage><epage>325</epage><pages>321-325</pages><issn>0350-6134</issn><abstract>We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.</abstract><cop>Croatia</cop><pmid>16117343</pmid><tpages>5</tpages></addata></record> |
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| subjects | Animals Anti-Ulcer Agents - pharmacology Corneal Diseases - drug therapy Corneal Diseases - veterinary Epithelium Male Peptide Fragments - pharmacology Proteins - pharmacology Rats Rats, Wistar |
| title | Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats |
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