Human diseases reveal novel roles for neural laminins
Extracellular matrix molecules such as laminins have a central role in regulating cell behaviour. However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise s...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2005-09, Vol.28 (9), p.480-486 |
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| container_title | Trends in neurosciences (Regular ed.) |
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| creator | Colognato, Holly ffrench-Constant, Charles Feltri, Maria Laura |
| description | Extracellular matrix molecules such as laminins have a central role in regulating cell behaviour. However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise strategies to enhance repair. Here, we review how insights gained from human diseases caused by genetic mutations in laminins or their receptors have revealed significant and sometimes unexpected roles for laminins in neural stem cells, migrating neurons and myelinating glia, in both the PNS and CNS. |
| doi_str_mv | 10.1016/j.tins.2005.07.004 |
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However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise strategies to enhance repair. Here, we review how insights gained from human diseases caused by genetic mutations in laminins or their receptors have revealed significant and sometimes unexpected roles for laminins in neural stem cells, migrating neurons and myelinating glia, in both the PNS and CNS.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Movement - physiology</subject><subject>Cells</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Models. 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| language | eng |
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| subjects | Animals Biological and medical sciences Cell Movement - physiology Cells Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Laminin - genetics Laminin - metabolism Medical sciences Nervous system Nervous System - cytology Nervous System - metabolism Neuroglia - cytology Neuroglia - metabolism Neurology Neurons Neurons - cytology Neurons - metabolism Receptors, Laminin - metabolism Stem cells Stem Cells - cytology Stem Cells - metabolism Vertebrates: nervous system and sense organs |
| title | Human diseases reveal novel roles for neural laminins |
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