1-Substituted pyrazolo[1,5- c]quinazolines as novel Gly/NMDA receptor antagonists: Synthesis, biological evaluation, and molecular modeling study

The synthesis and Gly/NMDA, AMPA, and KA receptor binding affinity of a new set of 5,6-dihydro-pyrazolo[1,5- c]quinazoline-2-carboxylates bearing different substituents at position-1 are described. A molecular modeling study has been carried out to better understand receptor affinity and selectivity...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2005-10, Vol.13 (19), p.5536-5549
Hauptverfasser:	Varano, Flavia, Catarzi, Daniela, Colotta, Vittoria, Calabri, Francesca Romana, Lenzi, Ombretta, Filacchioni, Guido, Galli, Alessandro, Costagli, Chiara, Deflorian, Francesca, Moro, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptor antagonists Binding Sites Binding, Competitive Biological and medical sciences Crystallography, X-Ray Glutamatergic system (aspartate and other excitatory aminoacids) Gly/NMDA receptor antagonists Hydrogen Bonding Ionotropic glutamate receptors Ligands Medical sciences Models, Molecular Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pyrazoles - chemical synthesis Pyrazoles - pharmacology Pyrazoloquinazoline derivatives Quinazolines - chemical synthesis Quinazolines - pharmacology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!