The CD9 Tetraspanin Is Not Required for the Development of Peripheral B Cells or for Humoral Immunity
The CD9 tetraspanin is known to be expressed at high levels on marginal zone (MZ) B cells, B-1 B cells, and plasma cells, and its expression is believed to be dependent on signals derived via Btk. In CD9 null mice, however, the development and survival of MZ B cells, B-1 B cells, and plasma cells al...
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| Veröffentlicht in: | The Journal of immunology (1950) 2005-09, Vol.175 (5), p.2925-2930 |
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| container_issue | 5 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 175 |
| creator | Cariappa, Annaiah Shoham, Tsipi Liu, Haoyuan Levy, Shoshana Boucheix, Claude Pillai, Shiv |
| description | The CD9 tetraspanin is known to be expressed at high levels on marginal zone (MZ) B cells, B-1 B cells, and plasma cells, and its expression is believed to be dependent on signals derived via Btk. In CD9 null mice, however, the development and survival of MZ B cells, B-1 B cells, and plasma cells all appear to be unaffected, and humoral immune responses to T-dependent and T-independent Ags are similar to those seen in wild-type littermate controls. In wild-type mice, CD9 levels may serve to distinguish between the presumed MZ precursor B cell population in the spleen and other IgD-expressing transitional B cells that express lower levels of CD21 and CD1d. These results suggest that CD9 is dispensable for B cell development and humoral immunity, but that this protein may serve as an additional marker for the presumed MZ precursor population of splenic B cells. |
| doi_str_mv | 10.4049/jimmunol.175.5.2925 |
| format | Article |
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These results suggest that CD9 is dispensable for B cell development and humoral immunity, but that this protein may serve as an additional marker for the presumed MZ precursor population of splenic B cells.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>Antigens, CD - physiology</subject><subject>B-Lymphocytes - physiology</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Mice</subject><subject>Tetraspanin 29</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFLwzAUhYMobk5_gSB50qfOpEvS5lE7dQNRkfkcsvbWdbRNl7SO_XtTNtE34ZIL4TuHyzkIXVIyZoTJ23VRVV1tyjGN-JiPQxnyIzSknJNACCKO0ZCQMAxoJKIBOnNuTQgRJGSnaEAF9RPFQwSLFeBkKvECWqtdo-uixnOHX0yL32HTFRYynBuLW89N4QtK01RQt9jk-A1s0azA6hLf4wTK0mEP9vCsq0z_Pe8vLNrdOTrJdeng4rBH6OPxYZHMgufXp3ly9xykjNI2oLAUIHmqNRORlnnM45RpIFns3wgABNM6yrKJ0DQEkKlMo0xwLic8JYyzyQhd730bazYduFZVhUv9ZboG0zklYk5YGJJ_QR9pLFksPTjZg6k1zlnIVWOLStudokT1NaifGnqN4qqvwauuDvbdsoLsV3PI3QM3e2BVfK62PmTlKl2WHqdqu93-sfoGEuSTkA</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Cariappa, Annaiah</creator><creator>Shoham, Tsipi</creator><creator>Liu, Haoyuan</creator><creator>Levy, Shoshana</creator><creator>Boucheix, Claude</creator><creator>Pillai, Shiv</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>The CD9 Tetraspanin Is Not Required for the Development of Peripheral B Cells or for Humoral Immunity</title><author>Cariappa, Annaiah ; Shoham, Tsipi ; Liu, Haoyuan ; Levy, Shoshana ; Boucheix, Claude ; Pillai, Shiv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-1eb6e95caa467a9f858c4ae0d84ae7eee64aa7dd36a12ee9c9c7d655935c04543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>Antigens, CD - physiology</topic><topic>B-Lymphocytes - physiology</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Mice</topic><topic>Tetraspanin 29</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cariappa, Annaiah</creatorcontrib><creatorcontrib>Shoham, Tsipi</creatorcontrib><creatorcontrib>Liu, Haoyuan</creatorcontrib><creatorcontrib>Levy, Shoshana</creatorcontrib><creatorcontrib>Boucheix, Claude</creatorcontrib><creatorcontrib>Pillai, Shiv</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cariappa, Annaiah</au><au>Shoham, Tsipi</au><au>Liu, Haoyuan</au><au>Levy, Shoshana</au><au>Boucheix, Claude</au><au>Pillai, Shiv</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The CD9 Tetraspanin Is Not Required for the Development of Peripheral B Cells or for Humoral Immunity</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>175</volume><issue>5</issue><spage>2925</spage><epage>2930</epage><pages>2925-2930</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>The CD9 tetraspanin is known to be expressed at high levels on marginal zone (MZ) B cells, B-1 B cells, and plasma cells, and its expression is believed to be dependent on signals derived via Btk. 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| ispartof | The Journal of immunology (1950), 2005-09, Vol.175 (5), p.2925-2930 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antibody Formation Antigens, CD - physiology B-Lymphocytes - physiology Membrane Glycoproteins - physiology Mice Tetraspanin 29 |
| title | The CD9 Tetraspanin Is Not Required for the Development of Peripheral B Cells or for Humoral Immunity |
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