Melanocytic nevi are associated with neurofibromas in neurofibromatosis, type I, but not sporadic neurofibromas. A study of 226 cases
Background: Neurofibromatosis, type 1, is associated with cutaneous melanin pigmentation, but an association with ordinary melanocytic nevi has not been described. Methods: This retrospective case‐control study was designed to see if neurofibromas in patients with neurofibromatosis, type 1 (NF‐1)...
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| Veröffentlicht in: | Journal of cutaneous pathology 2005-09, Vol.32 (8), p.523-532 |
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| description | Background: Neurofibromatosis, type 1, is associated with cutaneous melanin pigmentation, but an association with ordinary melanocytic nevi has not been described.
Methods: This retrospective case‐control study was designed to see if neurofibromas in patients with neurofibromatosis, type 1 (NF‐1) differ from sporadic neurofibromas (SN) in their incidence of associated melanocytic nevi and other histologic features. Slides from 114 NF‐1 were compared with 112 SN and 300 intradermal melanocytic nevi (IDN).
Results: Small lentiginous melanocytic nevi were identified over 13 NF‐1 (11%) but no SN (P = 0.0002). Compared with other NF‐1, NF‐1 with nevi were more frequently associated with melanocytic hyperplasia, giant melanosomes and diffuse neurofibroma (P |
| doi_str_mv | 10.1111/j.0303-6987.2005.00376.x |
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Methods: This retrospective case‐control study was designed to see if neurofibromas in patients with neurofibromatosis, type 1 (NF‐1) differ from sporadic neurofibromas (SN) in their incidence of associated melanocytic nevi and other histologic features. Slides from 114 NF‐1 were compared with 112 SN and 300 intradermal melanocytic nevi (IDN).
Results: Small lentiginous melanocytic nevi were identified over 13 NF‐1 (11%) but no SN (P = 0.0002). Compared with other NF‐1, NF‐1 with nevi were more frequently associated with melanocytic hyperplasia, giant melanosomes and diffuse neurofibroma (P < 0.03). Compared with SN, NF‐1 were also more frequently associated with melanocytic hyperplasia, lentigo simplex‐like changes, diffuse neurofibroma and plexiform neurofibroma (P < 0.001). Sebaceous hyperplasia (14%), dermal elastosis (9%), lipomatous change (8%), epithelial cysts (4%) and keratin granulomas or folliculitis (3%) were not significantly different in prevalence between NF‐1, SN and the control group of IDN.
Conclusions: This study suggests that there is a difference in the potential for melanocytic proliferation in NF‐1 compared with SN. NF‐1, SN and IDN are associated with a similar range of incidental histologic changes.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/j.0303-6987.2005.00376.x</identifier><identifier>PMID: 16115049</identifier><identifier>CODEN: JCUPBN</identifier><language>eng</language><publisher>Oxford, UK; Malden, USA: Munksgaard International Publishers</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Case-Control Studies ; Cell Proliferation ; Dermatology ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Male ; Medical sciences ; Melanocytes - metabolism ; Melanocytes - pathology ; Middle Aged ; Neoplasms, Multiple Primary - etiology ; Neoplasms, Multiple Primary - metabolism ; Neoplasms, Multiple Primary - pathology ; Neurofibroma - complications ; Neurofibroma - metabolism ; Neurofibroma - pathology ; Neurofibromatosis 1 - complications ; Neurofibromatosis 1 - metabolism ; Neurofibromatosis 1 - pathology ; Neurology ; Nevus, Pigmented - complications ; Nevus, Pigmented - metabolism ; Nevus, Pigmented - pathology ; Retrospective Studies ; Skin Neoplasms - complications ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Tumors of the nervous system. Phacomatoses ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of cutaneous pathology, 2005-09, Vol.32 (8), p.523-532</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4346-aaf619475423133fc999777485348184b5295bd7430db8386950e89b980780ce3</citedby><cites>FETCH-LOGICAL-c4346-aaf619475423133fc999777485348184b5295bd7430db8386950e89b980780ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.0303-6987.2005.00376.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.0303-6987.2005.00376.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17043600$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16115049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ball, Nigel J.</creatorcontrib><creatorcontrib>Kho, Grace T.</creatorcontrib><title>Melanocytic nevi are associated with neurofibromas in neurofibromatosis, type I, but not sporadic neurofibromas. A study of 226 cases</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Background: Neurofibromatosis, type 1, is associated with cutaneous melanin pigmentation, but an association with ordinary melanocytic nevi has not been described.
Methods: This retrospective case‐control study was designed to see if neurofibromas in patients with neurofibromatosis, type 1 (NF‐1) differ from sporadic neurofibromas (SN) in their incidence of associated melanocytic nevi and other histologic features. Slides from 114 NF‐1 were compared with 112 SN and 300 intradermal melanocytic nevi (IDN).
Results: Small lentiginous melanocytic nevi were identified over 13 NF‐1 (11%) but no SN (P = 0.0002). Compared with other NF‐1, NF‐1 with nevi were more frequently associated with melanocytic hyperplasia, giant melanosomes and diffuse neurofibroma (P < 0.03). Compared with SN, NF‐1 were also more frequently associated with melanocytic hyperplasia, lentigo simplex‐like changes, diffuse neurofibroma and plexiform neurofibroma (P < 0.001). Sebaceous hyperplasia (14%), dermal elastosis (9%), lipomatous change (8%), epithelial cysts (4%) and keratin granulomas or folliculitis (3%) were not significantly different in prevalence between NF‐1, SN and the control group of IDN.
Conclusions: This study suggests that there is a difference in the potential for melanocytic proliferation in NF‐1 compared with SN. NF‐1, SN and IDN are associated with a similar range of incidental histologic changes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Case-Control Studies</subject><subject>Cell Proliferation</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanocytes - metabolism</subject><subject>Melanocytes - pathology</subject><subject>Middle Aged</subject><subject>Neoplasms, Multiple Primary - etiology</subject><subject>Neoplasms, Multiple Primary - metabolism</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neurofibroma - complications</subject><subject>Neurofibroma - metabolism</subject><subject>Neurofibroma - pathology</subject><subject>Neurofibromatosis 1 - complications</subject><subject>Neurofibromatosis 1 - metabolism</subject><subject>Neurofibromatosis 1 - pathology</subject><subject>Neurology</subject><subject>Nevus, Pigmented - complications</subject><subject>Nevus, Pigmented - metabolism</subject><subject>Nevus, Pigmented - pathology</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms - complications</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v0zAchi0EYqXwFZAvcFrCz3H8T-IyKhiTNkAaE0fLcRzhksbFTljzAfjeuGu1wQ1fbNnPY1vvixAmUJI83qxLoEALrqQoKwBWAlDBy90jtCAcoADG4TFa3EMn6FlKawDCJWdP0QnhhDCo1QL9vnK9GYKdR2_x4H55bKLDJqVgvRldi2_9-D0fTDF0volhYxL2wz8bY0g-neJx3jp8cYqbacRDGHHahmjau1v_kkt8htM4tTMOHa4qjq1JLj1HTzrTJ_fiOC_RzYf3X1cfi8vP5xers8vC1rTmhTEdJ6oWrK4oobSzSikhRC0ZrSWRdcMqxZpW1BTaRlLJFQMnVaMkCAnW0SV6fbh3G8PPyaVRb3yyrs8RuDAlzSUDKnNqSyQPoI0hpeg6vY1-Y-KsCeh9BXqt9-nqfbp6X4G-q0Dvsvry-MbUbFz7IB4zz8CrI2CSNX0XzWB9euAE1DSXmLm3B-7W927-7w_o1c2XvMh6cdB9Gt3uXjfxh-aCCqa_fTrPIrl-d8WvNaV_AMXysBI</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Ball, Nigel J.</creator><creator>Kho, Grace T.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Melanocytic nevi are associated with neurofibromas in neurofibromatosis, type I, but not sporadic neurofibromas. A study of 226 cases</title><author>Ball, Nigel J. ; Kho, Grace T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4346-aaf619475423133fc999777485348184b5295bd7430db8386950e89b980780ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Case-Control Studies</topic><topic>Cell Proliferation</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanocytes - metabolism</topic><topic>Melanocytes - pathology</topic><topic>Middle Aged</topic><topic>Neoplasms, Multiple Primary - etiology</topic><topic>Neoplasms, Multiple Primary - metabolism</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neurofibroma - complications</topic><topic>Neurofibroma - metabolism</topic><topic>Neurofibroma - pathology</topic><topic>Neurofibromatosis 1 - complications</topic><topic>Neurofibromatosis 1 - metabolism</topic><topic>Neurofibromatosis 1 - pathology</topic><topic>Neurology</topic><topic>Nevus, Pigmented - complications</topic><topic>Nevus, Pigmented - metabolism</topic><topic>Nevus, Pigmented - pathology</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms - complications</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ball, Nigel J.</creatorcontrib><creatorcontrib>Kho, Grace T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ball, Nigel J.</au><au>Kho, Grace T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melanocytic nevi are associated with neurofibromas in neurofibromatosis, type I, but not sporadic neurofibromas. A study of 226 cases</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2005-09</date><risdate>2005</risdate><volume>32</volume><issue>8</issue><spage>523</spage><epage>532</epage><pages>523-532</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>Background: Neurofibromatosis, type 1, is associated with cutaneous melanin pigmentation, but an association with ordinary melanocytic nevi has not been described.
Methods: This retrospective case‐control study was designed to see if neurofibromas in patients with neurofibromatosis, type 1 (NF‐1) differ from sporadic neurofibromas (SN) in their incidence of associated melanocytic nevi and other histologic features. Slides from 114 NF‐1 were compared with 112 SN and 300 intradermal melanocytic nevi (IDN).
Results: Small lentiginous melanocytic nevi were identified over 13 NF‐1 (11%) but no SN (P = 0.0002). Compared with other NF‐1, NF‐1 with nevi were more frequently associated with melanocytic hyperplasia, giant melanosomes and diffuse neurofibroma (P < 0.03). Compared with SN, NF‐1 were also more frequently associated with melanocytic hyperplasia, lentigo simplex‐like changes, diffuse neurofibroma and plexiform neurofibroma (P < 0.001). Sebaceous hyperplasia (14%), dermal elastosis (9%), lipomatous change (8%), epithelial cysts (4%) and keratin granulomas or folliculitis (3%) were not significantly different in prevalence between NF‐1, SN and the control group of IDN.
Conclusions: This study suggests that there is a difference in the potential for melanocytic proliferation in NF‐1 compared with SN. NF‐1, SN and IDN are associated with a similar range of incidental histologic changes.</abstract><cop>Oxford, UK; Malden, USA</cop><pub>Munksgaard International Publishers</pub><pmid>16115049</pmid><doi>10.1111/j.0303-6987.2005.00376.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Biomarkers, Tumor - metabolism Case-Control Studies Cell Proliferation Dermatology Female Fluorescent Antibody Technique, Indirect Humans Male Medical sciences Melanocytes - metabolism Melanocytes - pathology Middle Aged Neoplasms, Multiple Primary - etiology Neoplasms, Multiple Primary - metabolism Neoplasms, Multiple Primary - pathology Neurofibroma - complications Neurofibroma - metabolism Neurofibroma - pathology Neurofibromatosis 1 - complications Neurofibromatosis 1 - metabolism Neurofibromatosis 1 - pathology Neurology Nevus, Pigmented - complications Nevus, Pigmented - metabolism Nevus, Pigmented - pathology Retrospective Studies Skin Neoplasms - complications Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumors of the nervous system. Phacomatoses Tumors of the skin and soft tissue. Premalignant lesions |
| title | Melanocytic nevi are associated with neurofibromas in neurofibromatosis, type I, but not sporadic neurofibromas. A study of 226 cases |
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